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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorBORGES, Marcus Kiiti-
dc.contributor.authorLOPES, Thais Nakayama-
dc.contributor.authorBIELLA, Marina Maria-
dc.contributor.authorSIQUEIRA, Alaise-
dc.contributor.authorMAUER, Sivan-
dc.contributor.authorAPRAHAMIAN, Ivan-
dc.identifier.citationFRONTIERS IN PSYCHIATRY, v.9, article ID 469, 5p, 2018-
dc.description.abstractBackground: Alzheimer's disease (AD) is traditionally subdivided into early onset (EOAD) and late onset (LOAD). EOAD has an onset before age 65 years and accounts for 1-5% of all cases. Two main presentation types of AD are familial and sporadic. Case presentation: The authors present the case of a 68-year-old retired white man, with a college level educational background. At 55 years of age, the patient presented cognitive decline with short-term memory impairment and slowed, hesitant speech. At 57 years, he was unable to remember the way to work, exhibiting spatial disorientation. PET-CT: revealed hypometabolism and atrophy in the left temporal lobe and posterior region of the parietal lobes. Disease course: Evolving with difficulties in comprehension and sentence repetition over past 3 years and with global aphasia in past 6 months, beyond progressive memory impairment. Discussion: Possibly due to the young age and atypical presentation, and the diagnosis of EOAD is often delayed. To the best of our knowledge, this case can be classified as a sporadic EOAD with aphasia. Clinical variant and neuroimaging findings were crucial to the diagnosis and treatment of this atypical presentation of AD.-
dc.relation.ispartofFrontiers in Psychiatry-
dc.subjectAlzheimer's disease-
dc.subjectearly onset-
dc.subjectcase report-
dc.subject.otherdomino-ad trial-
dc.titleEarly-Onset Alzheimer Disease (EOAD) With Aphasia: A Case Report-
dc.rights.holderCopyright FRONTIERS MEDIA SA-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Marcus Kiiti:FEAES, Dept Geriatr Psychiat, Curitiba, Parana, Brazil; Univ Sao Paulo, Dept Geriatr, ACID Ambulatorio Alteracoes Comportamentais Idoso, Hosp Ciln, Sao Paulo, Brazil; FMUSP, Dept Psychiat, Sao Paulo, Brazil-, Thais Nakayama:FEAES, Dept Geriatr Psychiat, Curitiba, Parana, Brazil-, Marina Maria:Univ Sao Paulo, Dept Geriatr, ACID Ambulatorio Alteracoes Comportamentais Idoso, Hosp Ciln, Sao Paulo, Brazil; FMUSP, Dept Psychiat, Sao Paulo, Brazil-
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