Higher IQ in juvenile myoclonic epilepsy: Dodging cognitive obstacles and ""masking"" impairments

Abstract

Executive deficits and impulsiveness are extensively reported in juvenile myoclonic epilepsy (JME). Previous literature suggests that intelligence may mediate these deficits. In this study, we evaluated and compared the performance of adults with JME with high and low intelligence quotient (IQ) and controls on tasks for executive function (EF) and impulsive trails. We investigated the neuropsychological performance of 53 adults with JME and below average IQ (57% women; 26.9 [+/- 7.88] years; mean IQ: 89.8 [+/- 5.1]), 26 adults with JME and average or above average IQ (53.8% women; 28.2 [+/- 9.33] years; mean IQ: 110.7 [+/- 8.3]), 38 controls with below average IQ (55% women; 28.4 [+/- 8.4] years; mean IQ: 90.1 [+/- 5.8]), and 31 controls with average or above average IQ (61.3% women; 32.20 [+/- 11.3] years; mean IQ: 111.6[+/- 10.5]) with a comprehensive battery of neuropsychological tests that measure executive/attentional function. Impulsive traits were assessed using the Cloninger et al.'s Temperament and Character Inventory (novelty seeking (NS) domain). The group with JME with higher IQ presented worse performance compared with controls with higher IQ on Controlled Oral Word Association (COWA) and Wisconsin Card Sorting Test (WCST) (errors). This group showed worse performance than controls with lower IQ on Stroop Color-Word Test (SCT) 1, Trail Making (TM) A, COWA, and WCST (errors). Patients with lower IQ showed worse performance than controls with higher IQ on Digit Span Forward (DSF), Digit Span Backward (DSB), SCT1, SCT2, SCT3, TM A, COWA, and WCST (errors and failure to maintain set). Patients with lower IQ showed worse performance than controls with lower IQ on DSF, DSB, SCTI, SCT2, SCT3, TM A, TM B, COWA, and WCST (errors and failure to maintain set). Patients from groups with low and high IQ showed higher scores than controls with higher and lower IQ on impulsivity for NS1 and NS2 (except for patients with higher IQ versus controls with lower IQ). Adults with JME and higher IQ show less evidence of EF deficits compared with those with JME and below average IQ suggesting that a higher degree of intellectual efficiency may act as a compensatory mechanism. However, it does not minimize some aspects of impulsive traits. Patients with JME and higher cognitive reserve may create strategies to dodge their cognitive obstacles. In this context, intelligence may protect and, at the same time, ""mask"" impairments that could be detected earlier.