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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorCOSTA-URRUTIA, Paula-
dc.contributor.authorABUD, Carolina-
dc.contributor.authorFRANCO-TRECU, Valentina-
dc.contributor.authorCOLISTRO, Valentina-
dc.contributor.authorRODRIGUEZ-ARELLANO, Martha Eunice-
dc.contributor.authorGRANADOS, Julio-
dc.contributor.authorSEELAENDER, Marilia-
dc.identifier.citationPRIMARY CARE DIABETES, v.12, n.5, p.416-424, 2018-
dc.description.abstractPre diabetes mellitus (pre-DM) is considered an early-reversible condition that can progress to Type 2 diabetes mellitus (T2DM) which is the main cause of death for adult Mexican population. Gene variants influencing fasting glucose levels may constitute helpful tool for prevention purposes in pre-DM condition. Physically active Mexican-Mestizo adults (n=565) were genotyped for 6 single nucleotide polymorphisms (SNPs) (ADIPOQ rs2241766, ACSL1 rs9997745, LIPC rs1800588, PPARA rs1800206, PPARG rs1801282 and PPARGC1A rs8192678) related to lipid and carbohydrate metabolism. Fasting glucose was measured and values classified as pre-DM (>= 100 mg/dL) or normal fasting glucose. Logistic models were used to test associations between pre-DM condition and SNPs, and interaction with Body Mass Index (BMI) and physical fitness components. The A allele of ASCL1 rs9997745 conferred increased risk (OR = 3.39, p = 0.001) of pre-DM which is modulated by BMI. The A allele of the PPARGC1A rs8192678 showed significant SNP*BMI (OR = 1.10, p = 0.008) interaction effect for pre-DM risk, meaning that obese subjects showed higher pre-DM risk but normal weight subjects showed lower risk. The effect increased with age and was attenuated by higher cardiorespiratory values. We found that both ACSL1 rs9997745 and PPARGC1A rs8192678 are associated with pre-DM, and that BMI significantly modified their association.-
dc.publisherELSEVIER SCI LTD-
dc.relation.ispartofPrimary Care Diabetes-
dc.subjectGenetic susceptibility-
dc.subjectGene-environment interaction-
dc.subject.otherhepatic lipase-
dc.subject.othermetabolic syndrome-
dc.titleGenetic susceptibility to pre diabetes mellitus and related association with obesity and physical fitness components in Mexican-Mestizos-
dc.rights.holderCopyright ELSEVIER SCI LTD-
dc.subject.wosEndocrinology & Metabolism-
dc.subject.wosPrimary Health Care-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-, Paula:Univ Sao Paulo, Fac Med, Inst Biomed Sci, Dept Cell & Dev Biol, Av Prof Lineu Prestes 2415, Sao Paulo, Brazil; Sport City SA CV, Grp Marti, Blvd Adolfo Lopez Mateos 1181, Mexico City 01180, DF, Mexico-, Carolina:Sport City SA CV, Grp Marti, Blvd Adolfo Lopez Mateos 1181, Mexico City 01180, DF, Mexico-, Valentina:Univ Republica, Fac Ciencias, Dept Ecol & Evoluc, Igua 4225, Montevideo 11400, Uruguay-, Valentina:Univ Republica, Fac Med, Dept Genet, Av Gral Flores 2125, Montevideo 11800, Uruguay-, Martha Eunice:Hosp Reg Lic, Lab Med Genom, ISSSTE, Av Univ 1321, Mexico City 01030, DF, Mexico-, Julio:Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Trasplantes, Div Inmunogenet, Vasco de Quiroga 15, Mexico City 14080, DF, Mexico-
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Artigos e Materiais de Revistas Científicas - LIM/26
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ODS/03 - Saúde e bem-estar

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