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Title: Efficacy and safety of aripiprazole for the treatment of schizophrenia: an overview of systematic reviews
Authors: RIBEIRO, Esther Leticia AmorimLIMA, Tacio de MendoncaVIEIRA, Marcio Eduardo BergaminiSTORPIRTIS, SilviaAGUIAR, Patricia Melo
Citation: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, v.74, n.10, p.1215-1233, 2018
Abstract: PurposeTo conduct an overview to summarize the efficacy and safety of aripiprazole for the treatment of schizophrenia.MethodsA literature search was performed in PubMed, the Cochrane Library, LILACS, and the Centre for Reviews and Dissemination, for articles published until March 31, 2017. We included systematic reviews with meta-analyses of randomized controlled trials assessing the efficacy, and/or the safety of aripiprazole, for patients with schizophrenia. Two authors independently performed the study selection, data extraction, and quality assessment. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach and the Risk of Bias in Systematic Review (ROBIS) tool were used to appraise the quality of evidence and the risk of bias in the reviews, respectively.ResultsFourteen studies fulfilled the inclusion criteria. Aripiprazole showed efficacy similar to that of both typical and atypical antipsychotic drugs (except olanzapine and amisulpride). Aripiprazole caused significantly lower weight gain and alterations in glucose and cholesterol levels, as compared to clozapine, risperidone, and olanzapine. In addition, aripiprazole caused significantly fewer general extrapyramidal side effects, less use of antiparkinsonian drugs, and akathisia, compared with typical antipsychotic drugs and risperidone. The overall quality of evidence in the reviews ranged from very low to moderate, principally because of the risk of bias of original trials, inconsistency, and imprecision in the outcomes. According to the ROBIS tool, there are four reviews with high risk of bias and five with unclear risk of bias.ConclusionsAripiprazole exhibited efficacy similar to that of other antipsychotic drugs and a better safety profile than that of typical (i.e., less some extrapyramidal side effects) and atypical (i.e., less metabolic changes) antipsychotic drugs.
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Artigos e Materiais de Revistas Científicas - HU
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