Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/29839
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGRIFONI, Alba
dc.contributor.authorCOSTA-RAMOS, Priscilla
dc.contributor.authorPHAM, John
dc.contributor.authorTIAN, Yuan
dc.contributor.authorROSALES, Sandy L.
dc.contributor.authorSEUMOIS, Gregory
dc.contributor.authorSIDNEY, John
dc.contributor.authorSILVA, Aruna D. de
dc.contributor.authorPREMKUMAR, Lakshmanane
dc.contributor.authorCOLLINS, Matthew H.
dc.contributor.authorSTONE, Mars
dc.contributor.authorNORRIS, Phillip J.
dc.contributor.authorROMERO, Claudia M. E.
dc.contributor.authorDURBIN, Anna
dc.contributor.authorRICCIARDI, Michael J.
dc.contributor.authorLEDGERWOOD, Julie E.
dc.contributor.authorSILVA, Aravinda M. de
dc.contributor.authorBUSCH, Michael
dc.contributor.authorPETERS, Bjoern
dc.contributor.authorVIJAYANAND, Pandurangan
dc.contributor.authorHARRIS, Eva
dc.contributor.authorFALCONAR, Andrew K.
dc.contributor.authorKALLAS, Esper
dc.contributor.authorWEISKOPF, Daniela
dc.contributor.authorSETTE, Alessandro
dc.date.accessioned2019-01-17T13:28:27Z-
dc.date.available2019-01-17T13:28:27Z-
dc.date.issued2018
dc.identifier.citationJOURNAL OF IMMUNOLOGY, v.201, n.12, p.3487-3491, 2018
dc.identifier.issn0022-1767
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/29839-
dc.description.abstractZika virus (ZIKV) constitutes an increasing public health problem. Previous studies have shown that CD8(+) T cells play an important role in ZIKV-specific protective immunity. We have previously defined antigenic targets of the ZIKV-specific CD8(+) T cell response in humans. In this study, we characterized the quality and phenotypes of these responses by a combined use of flow cytometry and transcriptomic methods, using PBMCs from donors deriving from different geographical locations collected in the convalescent phase of infection. We show that ZIKV-specific CD8(+) T cells are characterized by a polyfunctional IFN-gamma signature with upregulation of TNF-alpha, TNF receptors, and related activation markers, such as CD69, as well as a cytotoxic signature characterized by strong upregulation of GZMB and CRTAM. The signature is stable and not influenced by previous dengue virus exposure, geographical location, or time of sample collection postinfection. To our knowledge, this work elucidates the first in-depth characterization of human CD8(+) T cells responding to ZIKV infection.eng
dc.description.sponsorshipNational Institutes of Health (NIH) [HHSN272200900042C, HHSN27220140045C, U19 AI118626-01, HHSN268201100001I, S10OD016262]
dc.description.sponsorshipZika Preparedness Latin American Network from the European Union's Horizon 2020 research and innovation program [734584]
dc.description.sponsorshipShared Instrumentation Grant Program [S10 RR027366]
dc.description.sponsorshipNIH [S10OD016262]
dc.language.isoeng
dc.publisherAMER ASSOC IMMUNOLOGISTSeng
dc.relation.ispartofJournal of Immunology
dc.rightsrestrictedAccesseng
dc.subject.otherdengueeng
dc.subject.otherinfectioneng
dc.titleCutting Edge: Transcriptional Profiling Reveals Multifunctional and Cytotoxic Antiviral Responses of Zika Virus-Specific CD8(+) T Cellseng
dc.typearticleeng
dc.rights.holderCopyright AMER ASSOC IMMUNOLOGISTSeng
dc.identifier.doi10.4049/jimmunol.1801090
dc.identifier.pmid30413672
dc.subject.wosImmunologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalGRIFONI, Alba:La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA
hcfmusp.author.externalCOSTA-RAMOS, Priscilla:Univ Sao Paulo, Sch Med, Div Clin Immunol & Allergy, BR-01246903 Sao Paulo, Brazil
hcfmusp.author.externalPHAM, John:La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA
hcfmusp.author.externalTIAN, Yuan:La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA
hcfmusp.author.externalROSALES, Sandy L.:La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA
hcfmusp.author.externalSEUMOIS, Gregory:La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA
hcfmusp.author.externalSIDNEY, John:La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA
hcfmusp.author.externalSILVA, Aruna D. de:La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA; Genetech Res Inst, Colombo 08, Sri Lanka; Kotelawala Def Univ, Dept Paraclin Sci, Ratmalana, Sri Lanka
hcfmusp.author.externalPREMKUMAR, Lakshmanane:Univ N Carolina, Dept Microbiol & Immunol, Sch Med, Chapel Hill, NC 27516 USA
hcfmusp.author.externalCOLLINS, Matthew H.:Univ N Carolina, Dept Microbiol & Immunol, Sch Med, Chapel Hill, NC 27516 USA; Emory Univ, Dept Med, Sch Med, Hope Clin,Emory Vaccine Ctr,Div Infect Dis, Decatur, GA 30317 USA
hcfmusp.author.externalSTONE, Mars:Blood Syst Res Inst, San Francisco, CA 94118 USA
hcfmusp.author.externalNORRIS, Phillip J.:Blood Syst Res Inst, San Francisco, CA 94118 USA
hcfmusp.author.externalROMERO, Claudia M. E.:Univ Norte, Barranquilla 1569, Colombia
hcfmusp.author.externalDURBIN, Anna:Univ Vermont, Sch Med, Burlington, VT 05405 USA
hcfmusp.author.externalRICCIARDI, Michael J.:Univ Miami, Miller Sch Med, Dept Pathol, Miami, FL 33146 USA
hcfmusp.author.externalLEDGERWOOD, Julie E.:NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA
hcfmusp.author.externalSILVA, Aravinda M. de:Univ N Carolina, Dept Microbiol & Immunol, Sch Med, Chapel Hill, NC 27516 USA
hcfmusp.author.externalBUSCH, Michael:Blood Syst Res Inst, San Francisco, CA 94118 USA
hcfmusp.author.externalPETERS, Bjoern:La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA; Univ Calif San Diego, La Jolla, CA 92093 USA
hcfmusp.author.externalVIJAYANAND, Pandurangan:La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA
hcfmusp.author.externalHARRIS, Eva:Univ Calif Berkeley, Sch Publ Hlth, Div Infect Dis & Vacdnol, Berkeley, CA 94720 USA
hcfmusp.author.externalFALCONAR, Andrew K.:Univ Norte, Barranquilla 1569, Colombia
hcfmusp.author.externalWEISKOPF, Daniela:La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA
hcfmusp.author.externalSETTE, Alessandro:La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA; Univ Calif San Diego, La Jolla, CA 92093 USA
hcfmusp.description.beginpage3487
hcfmusp.description.endpage3491
hcfmusp.description.issue12
hcfmusp.description.volume201
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000452626700002
hcfmusp.origem.id2-s2.0-85058393976
hcfmusp.publisher.cityBETHESDAeng
hcfmusp.publisher.countryUSAeng
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dc.description.indexMEDLINEeng
dc.identifier.eissn1550-6606
hcfmusp.citation.scopus44-
hcfmusp.scopus.lastupdate2024-03-29-
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