Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/29869
Title: Obstructive Sleep Apnea is Common and Associated with Heart Remodeling in Patients with Chagas Disease
Authors: MEDEIROS, Carolina de AraujoSECUNDO, Isaac VieiraSILVEIRA, Carlos Antonio da MotaCASTILHO, Jose Maria delALBUQUERQUE, Afonso Tuiz Tavares deMARTINS, Silvia MarinhoOLIVEIRA JUNIOR, Wilson deLORENZI-FILHO, GeraldoDRAGER, Luciano E.PEDROSA, Rodrigo Pinto
Citation: ARQUIVOS BRASILEIROS DE CARDIOLOGIA, v.111, n.3, p.364-372, 2018
Abstract: Background: Chagas Disease (CD) is an important cause of morbimortality due to heart failure and malignant arrhythmias worldwide, especially in Latin America. Objective: To investigate the association of obstructive sleep apnea (OSA) with heart remodeling and cardiac arrhythmias in patients CD. Methods: Consecutive patients with CD, aged between 30 to 65 years old were enrolled. Participants underwent clinical evaluation, sleep study, 24-hour Hotter monitoring, echocardiogram and ambulatory blood pressure monitoring. Results: We evaluated 135 patients [age: 56 (45-62) yeas; 30% men; BMI: 26 +/- 4 kg/m2, Chagas cardiomyopathy: 70%]. Moderate to severe OSA (apnea-hypopnea index, AHI, >= 15 events/h) was present in 21% of the patients. OSA was not associated with arrhythmias in this population. As compared to patients with mild or no OSA, patients with moderate to severe OSA had higher frequency of hypertension (79% vs. 72% vs. 44%, p < 0.01) higher nocturnal systolic blood pressure: 119 +/- 17 vs. 113 +/- 13 vs. 110 +/- 11 mmHg, p = 0.01; larger left atrial diameter (37 (33-42) vs. 35 (33-39) vs. 33 (30-36) mm, p < 0.01]; and a greater proportion of left ventricular dysfunction [LVEF < 50% (39% vs. 28% vs. 11%), p < 0.01], respectively. Predictor of left atrial dimension was Log(10) (AHI) (beta = 3.86, 95% CI: 1.91 to 5.81; p < 0.01). Predictors of ventricular dysfunction were AHI > 15 events/h (OR = 3.61, 95% CI: 1.31 - 9.98; p = 0.01), systolic blood pressure (OR = 1.06, 95% CI: 1.02 -1.10; p < 0.01) and male gender (OR = 3.24, 95% CI: 1.31 - 8.01; p = 0.01). Conclusions: OSA is independently associated with atrial and ventricular remodeling in patients with CD.
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Departamento de Cardio-Pneumologia - FM/MCP

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Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/09
LIM/09 - Laboratório de Pneumologia


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