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Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/29897
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorALCANTARA FILHO, Paulo R. de
dc.contributor.authorMANGONE, Flavia R.
dc.contributor.authorPAVANELLI, Ana C.
dc.contributor.authorGARCIA, Simone A. de Bessa
dc.contributor.authorNONOGAKI, Suely
dc.contributor.authorOSORIO, Cynthia A. B. de Toledo
dc.contributor.authorANDRADE, Victor P. de
dc.contributor.authorNAGAI, Maria A.
dc.date.accessioned2019-01-17T13:29:17Z
dc.date.available2019-01-17T13:29:17Z
dc.date.issued2018
dc.identifier.citationBREAST CANCER MANAGEMENT, v.7, n.2, article ID UNSP BMT09, 18p, 2018
dc.identifier.issn1758-1923
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/29897
dc.description.abstractAim: To determine the expression signature of triple-negative breast cancer (TNBC) with differences of secreted protein acidic and rich in cysteine expression and clinical behavior. Patients, materials & methods: cDNA microarray analysis was performed to determine the expression profiling of TNBC, characterized regarding secreted protein acidic and rich in cysteine expression status. Immunohistochemistry analysis on tissue microarrays containing an independent cohort of TNBC was performed for validation. Results: Negative staining of SOHLH2 and positive staining of DNAJC12 and LIM1 was correlated with a poor outcome of the patients. Conclusion: Our findings provide new information on transcriptome changes associated with the clinical behavior of TNBC that may serve as a potential tool for the identification and characterization of new candidate biomarkers.eng
dc.description.sponsorshipFundaco de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/07035-4]
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [303134/2013-5]
dc.language.isoeng
dc.publisherFUTURE MEDICINE LTDeng
dc.relation.ispartofBreast Cancer Management
dc.rightsopenAccesseng
dc.subjectexpression profilingeng
dc.subjectimmunohistochemistryeng
dc.subjectprotein expressioneng
dc.subjectSPARCeng
dc.subjecttissue microarrayeng
dc.subjecttriple-negative breast cancereng
dc.subject.othercancer patientseng
dc.subject.otherovarian-cancereng
dc.subject.otherneck-cancereng
dc.subject.otheroverexpressioneng
dc.subject.otherprevalenceeng
dc.subject.otherrecurrenceeng
dc.subject.otherestrogeneng
dc.subject.othertherapyeng
dc.subject.othersubtypeeng
dc.subject.othersohlh2eng
dc.titleGene expression profiling of triple-negative breast tumors with different expression of secreted protein acidic and cysteine rich (SPARC)eng
dc.typearticleeng
dc.rights.holderCopyright FUTURE MEDICINE LTDeng
dc.identifier.doi10.2217/bmt-2017-0019
dc.subject.wosOncologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalNONOGAKI, Suely:AC Camargo Canc Ctr, Dept Pathol, BR-01509020 Sao Paulo, Brazil
hcfmusp.author.externalOSORIO, Cynthia A. B. de Toledo:AC Camargo Canc Ctr, Dept Pathol, BR-01509020 Sao Paulo, Brazil
hcfmusp.author.externalANDRADE, Victor P. de:AC Camargo Canc Ctr, Dept Pathol, BR-01509020 Sao Paulo, Brazil
hcfmusp.description.articlenumberUNSP BMT09
hcfmusp.description.issue2
hcfmusp.description.volume7
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000448922300001
hcfmusp.publisher.cityLONDONeng
hcfmusp.publisher.countryENGLANDeng
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dc.identifier.eissn1758-1931
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MDR
Departamento de Radiologia - FM/MDR

Artigos e Materiais de Revistas Científicas - HC/ICESP
Instituto do Câncer do Estado de São Paulo - HC/ICESP

Artigos e Materiais de Revistas Científicas - LIM/24
LIM/24 - Laboratório de Oncologia Experimental


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