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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorDEZAN, Marcia Regina
dc.contributor.authorOLIVEIRA, Valeria B.
dc.contributor.authorGOMES, Carolina Nunes
dc.contributor.authorLUZ, Fabio
dc.contributor.authorGALLUCCI, Antonio J.
dc.contributor.authorBONIFACIO, Silvia L.
dc.contributor.authorALENCAR, Cecilia Salete
dc.contributor.authorSABINO, Ester C.
dc.contributor.authorPEREIRA, Alexandre C.
dc.contributor.authorKRIEGER, Jose E.
dc.contributor.authorROCHA, Vanderson
dc.contributor.authorMENDRONE-JUNIOR, Alfredo
dc.contributor.authorDINARDO, Carla L.
dc.identifier.citationJOURNAL OF CLINICAL LABORATORY ANALYSIS, v.32, n.9, article ID e22596, 8p, 2018
dc.description.abstractBackground Goal The current transfusion policy recommended for individuals with serologic weak-D phenotype is based on data derived from European-descent populations. Data referring to the distribution of RH alleles underlying weak-D phenotype among people of mixed origin are yet incomplete, and the applicability of European-based transfusion guidelines to this specific population is questionable. To evaluate the distribution of RHD variant genotype among individuals with serologic weak-D phenotype of both African and European descent. Methods Results Donors and patients of mixed origin and with serologic weak-D phenotype were selected for the study. They were investigated using conventional RHD-PCR assays and RHD whole-coding region direct sequencing. One hundred and six donors and 58 patients were included. There were 47 donors and 29 patients with partial-D genotype (47/106, 44.3%, and 29/58, 50%, respectively). RHD*DAR and RHD*weak D type 38 represented the most common altered RHD alleles among donors (joint frequency of 39.6%), while weak D types 1-3 accounted for 10.4% of the total D variant samples. RHD*DAR was the most common allele identified in the patient group (frequency of 31%), and weak D types 1-3 represented 29.3% of the total. Conclusion The frequency of partial D among mixed individuals with serologic weak-D phenotype is high. They should be managed as D-negative patients until molecular tests are complete.eng
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [420168/2016-8]
dc.relation.ispartofJournal of Clinical Laboratory Analysis
dc.subjectmixed populationeng
dc.subjectpartial Deng
dc.subjectweak Deng
dc.titleHigh frequency of variant RHD genotypes among donors and patients of mixed origin with serologic weak-D phenotypeeng
dc.rights.holderCopyright WILEYeng
dc.subject.wosMedical Laboratory Technologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Carolina Nunes:Fundacao Prosangue Hemoctr Sao PauloSao Paulo, Immunohematol, Sao Paulo, Brazil, Fabio:Fundacao Prosangue Hemoctr Sao PauloSao Paulo, Immunohematol, Sao Paulo, Brazil, Antonio J.:Fundacao Prosangue Hemoctr Sao PauloSao Paulo, Immunohematol, Sao Paulo, Brazil
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Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - FM/MCP
Departamento de Cardio-Pneumologia - FM/MCP

Artigos e Materiais de Revistas Científicas - FM/MIP
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Artigos e Materiais de Revistas Científicas - IMT
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Artigos e Materiais de Revistas Científicas - LIM/03
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