Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/29948
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorDEZAN, Marcia Regina
dc.contributor.authorOLIVEIRA, Valeria B.
dc.contributor.authorGOMES, Carolina Nunes
dc.contributor.authorLUZ, Fabio
dc.contributor.authorGALLUCCI, Antonio J.
dc.contributor.authorBONIFACIO, Silvia L.
dc.contributor.authorALENCAR, Cecilia Salete
dc.contributor.authorSABINO, Ester C.
dc.contributor.authorPEREIRA, Alexandre C.
dc.contributor.authorKRIEGER, Jose E.
dc.contributor.authorROCHA, Vanderson
dc.contributor.authorMENDRONE-JUNIOR, Alfredo
dc.contributor.authorDINARDO, Carla L.
dc.date.accessioned2019-01-17T13:33:14Z
dc.date.available2019-01-17T13:33:14Z
dc.date.issued2018
dc.identifier.citationJOURNAL OF CLINICAL LABORATORY ANALYSIS, v.32, n.9, article ID e22596, 8p, 2018
dc.identifier.issn0887-8013
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/29948
dc.description.abstractBackground Goal The current transfusion policy recommended for individuals with serologic weak-D phenotype is based on data derived from European-descent populations. Data referring to the distribution of RH alleles underlying weak-D phenotype among people of mixed origin are yet incomplete, and the applicability of European-based transfusion guidelines to this specific population is questionable. To evaluate the distribution of RHD variant genotype among individuals with serologic weak-D phenotype of both African and European descent. Methods Results Donors and patients of mixed origin and with serologic weak-D phenotype were selected for the study. They were investigated using conventional RHD-PCR assays and RHD whole-coding region direct sequencing. One hundred and six donors and 58 patients were included. There were 47 donors and 29 patients with partial-D genotype (47/106, 44.3%, and 29/58, 50%, respectively). RHD*DAR and RHD*weak D type 38 represented the most common altered RHD alleles among donors (joint frequency of 39.6%), while weak D types 1-3 accounted for 10.4% of the total D variant samples. RHD*DAR was the most common allele identified in the patient group (frequency of 31%), and weak D types 1-3 represented 29.3% of the total. Conclusion The frequency of partial D among mixed individuals with serologic weak-D phenotype is high. They should be managed as D-negative patients until molecular tests are complete.eng
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [420168/2016-8]
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofJournal of Clinical Laboratory Analysis
dc.rightsrestrictedAccesseng
dc.subjectalloimmunizationeng
dc.subjectdonorseng
dc.subjectmixed populationeng
dc.subjectpartial Deng
dc.subjectweak Deng
dc.subject.othersickle-cell-diseaseeng
dc.subject.othertransfusioneng
dc.subject.otheralleleseng
dc.subject.otherstrategyeng
dc.subject.otherbrazilianseng
dc.subject.otherzygosityeng
dc.subject.othermutationeng
dc.subject.othertimeeng
dc.titleHigh frequency of variant RHD genotypes among donors and patients of mixed origin with serologic weak-D phenotypeeng
dc.typearticleeng
dc.rights.holderCopyright WILEYeng
dc.identifier.doi10.1002/jcla.22596
dc.identifier.pmid29943480
dc.subject.wosMedical Laboratory Technologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalGOMES, Carolina Nunes:Fundacao Prosangue Hemoctr Sao PauloSao Paulo, Immunohematol, Sao Paulo, Brazil
hcfmusp.author.externalLUZ, Fabio:Fundacao Prosangue Hemoctr Sao PauloSao Paulo, Immunohematol, Sao Paulo, Brazil
hcfmusp.author.externalGALLUCCI, Antonio J.:Fundacao Prosangue Hemoctr Sao PauloSao Paulo, Immunohematol, Sao Paulo, Brazil
hcfmusp.description.articlenumbere22596
hcfmusp.description.issue9
hcfmusp.description.volume32
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000449547000014
hcfmusp.origem.id2-s2.0-85056170218
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
hcfmusp.relation.referenceCampos FCA, 2016, J CLIN LAB ANAL, V30, P845, DOI 10.1002/jcla.21946eng
hcfmusp.relation.referenceArnoni CP, 2014, TRANSFUSION, V54, P962, DOI 10.1111/trf.12557eng
hcfmusp.relation.referenceBub CB, 2018, J CLIN LAB ANAL, V32, DOI 10.1002/jcla.22221eng
hcfmusp.relation.referenceChiu RWK, 2001, CLIN CHEM, V47, P667eng
hcfmusp.relation.referenceChou ST, 2013, BLOOD, V122, P1062, DOI 10.1182/blood-2013-03-490623eng
hcfmusp.relation.referenceDaniels G, 2013, BRIT J HAEMATOL, V161, P461, DOI 10.1111/bjh.12275eng
hcfmusp.relation.referenceDezan M. R., 2016, ISBT SCI SERIES, V11, P132eng
hcfmusp.relation.referenceDezan MR, 2017, BLOOD CELL MOL DIS, V65, P8, DOI 10.1016/j.bcmd.2017.03.014eng
hcfmusp.relation.referenceDezan MR, 2018, TRANSFUSION, V58, P317, DOI 10.1111/trf.14425eng
hcfmusp.relation.referenceFlegel WA, 2007, J OBSTET GYNAECOL CA, V29, P746, DOI 10.1016/S1701-2163(16)32606-8eng
hcfmusp.relation.referenceFlegel WA, 2011, TRANSFUS APHER SCI, V44, P81, DOI 10.1016/j.transci.2010.12.013eng
hcfmusp.relation.referenceFlegel WA, 2009, TRANSFUSION, V49, P465, DOI 10.1111/j.1537-2995.2008.01975.xeng
hcfmusp.relation.referenceGarcia F, 2015, TRANSFUSION, V55, P427, DOI 10.1111/trf.12828eng
hcfmusp.relation.referenceMaaskant-van Wijk PA, 1998, TRANSFUSION, V38, P1015, DOI 10.1046/j.1537-2995.1998.38111299056309.xeng
hcfmusp.relation.referenceMilkins C, 2013, TRANSFUSION MED, V23, P3, DOI 10.1111/j.1365-3148.2012.01199.xeng
hcfmusp.relation.referenceMuller TH, 2001, TRANSFUSION, V41, P45, DOI 10.1046/j.1537-2995.2001.41010045.xeng
hcfmusp.relation.referenceOuchari M, 2018, TRANSFUSION, V58, P306, DOI 10.1111/trf.14411eng
hcfmusp.relation.referenceParra FC, 2003, P NATL ACAD SCI USA, V100, P177, DOI 10.1073/pnas.0126614100eng
hcfmusp.relation.referencePerco P, 2003, TRANSFUSION, V43, P335, DOI 10.1046/j.1537-2995.2003.00313.xeng
hcfmusp.relation.referenceReid ME, 2014, BLOOD CELL MOL DIS, V52, P195, DOI 10.1016/j.bcmd.2013.11.003eng
hcfmusp.relation.referenceSandler SG, 2015, TRANSFUSION, V55, P680, DOI 10.1111/trf.12941eng
hcfmusp.relation.referenceSingleton BK, 2000, BLOOD, V95, P12eng
hcfmusp.relation.referenceTax MGHM, 2002, TRANSFUSION, V42, P634, DOI 10.1046/j.1537-2995.2002.00096.xeng
hcfmusp.relation.referenceWagner FF, 2000, BLOOD, V95, P2699eng
hcfmusp.relation.referenceWagner FF, 1998, BLOOD, V91, P2157eng
hcfmusp.relation.referenceWagner FF, 1999, BLOOD, V93, P385eng
dc.description.indexMEDLINEeng
dc.identifier.eissn1098-2825
hcfmusp.citation.scopus5
hcfmusp.scopus.lastupdate2022-07-22-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - FM/MCP
Departamento de Cardio-Pneumologia - FM/MCP

Artigos e Materiais de Revistas Científicas - FM/MIP
Departamento de Moléstias Infecciosas e Parasitárias - FM/MIP

Artigos e Materiais de Revistas Científicas - HC/ICESP
Instituto do Câncer do Estado de São Paulo - HC/ICESP

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - IMT
Instituto de Medicina Tropical - IMT

Artigos e Materiais de Revistas Científicas - LIM/03
LIM/03 - Laboratório de Medicina Laboratorial

Artigos e Materiais de Revistas Científicas - LIM/13
LIM/13 - Laboratório de Genética e Cardiologia Molecular

Artigos e Materiais de Revistas Científicas - LIM/31
LIM/31 - Laboratório de Genética e Hematologia Molecular

Artigos e Materiais de Revistas Científicas - LIM/46
LIM/46 - Laboratório de Parasitologia Médica

Artigos e Materiais de Revistas Científicas - LIM/52
LIM/52 - Laboratório de Virologia


Files in This Item:
File Description SizeFormat 
art_DEZAN_High_frequency_of_variant_RHD_genotypes_among_donors_2018.PDF
  Restricted Access
publishedVersion (English)800.28 kBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.