Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/30068
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSPADA, Tania C.
dc.contributor.authorSILVA, Jose M. R. D.
dc.contributor.authorFRANCISCO, Lucila S.
dc.contributor.authorMARCAL, Lia J.
dc.contributor.authorANTONANGELO, Leila
dc.contributor.authorZANETTA, Dirce M. T.
dc.contributor.authorYU, Luis
dc.contributor.authorBURDMANN, Emmanuel A.
dc.date.accessioned2019-01-17T13:36:45Z
dc.date.available2019-01-17T13:36:45Z
dc.date.issued2018
dc.identifier.citationPLOS ONE, v.13, n.11, article ID e0205791, 13p, 2018
dc.identifier.issn1932-6203
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/30068
dc.description.abstractPurpose High-intensity interval resistance training (HIIRT) is an increasingly popular exercise program that provides positive results with short sessions. This study aimed to evaluate whether an HIIRT session causes muscle and kidney damage. Methods Fifty-eight healthy volunteers (median age 24 years, 50% women) participated in this study and performed a HIIRT session. The Borg CR10 scale for pain (CR1OP) and blood and urine samples were collected before (baseline) and 2 and 24 hours after the HIIRT session. Blood samples were analyzed for serum creatinine (SCr), creatine kinase (CK) and myoglobin. Urine samples were assessed for creatinine, neutrophil gelatinase-associated lipocalin, interleukin 18, calbindin, microalbuminuria, trefoil factor-3 and beta-2 microglobulin. Results CR10P had a significant increase at 2 and 24 hours post-workout, and CK increased significantly at 2 hours and increased further at 24 hours. Myoglobin increased significantly at 2 hours and remained elevated at 24 hours. SCr increased modestly but significantly at 24 hours only in men. Three men met the KDIGO diagnostic criteria for acute kidney injury. The urinary kidney injury biomarkers increased significantly at 2 hours and returned to the baseline values 24 hours after HIIRT. Conclusions A single HIIRT session caused early and significant elevations in CK, myoglobin, SCr, microalbuminuria and urinary biomarkers indicative of kidney tubular injury, suggesting the occurrence of muscle and kidney damage.eng
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq - National Counsel of Technological and Scientific Development), Brazil [CNPq 133977/2015-3, CNPq 305858/2013-0]
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Sao Paulo Research Foundation), Sao Paulo, Brazil [FAPESP 2014/19286-4]
dc.language.isoeng
dc.publisherPUBLIC LIBRARY SCIENCEeng
dc.relation.ispartofPlos One
dc.rightsopenAccesseng
dc.subject.otherexercise-induced rhabdomyolysiseng
dc.subject.otherphysical-activityeng
dc.subject.otheranaerobic capacityeng
dc.subject.otherknowledgeeng
dc.subject.otherrecoveryeng
dc.subject.othersepsiseng
dc.subject.otherpaneleng
dc.titleHigh intensity resistance training causes muscle damage and increases biomarkers of acute kidney injury in healthy individualseng
dc.typearticleeng
dc.rights.holderCopyright PUBLIC LIBRARY SCIENCEeng
dc.identifier.doi10.1371/journal.pone.0205791
dc.identifier.pmid30399190
dc.subject.wosMultidisciplinary Scienceseng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalSILVA, Jose M. R. D.:Sao Paulo State Univ, Sch Sci, Bauru, Brazil
hcfmusp.author.externalFRANCISCO, Lucila S.:Univ Guarulhos, Div Sports, Guarulhos, Brazil
hcfmusp.author.externalZANETTA, Dirce M. T.:Univ Sao Paulo, Sch Publ Hlth, Sao Paulo, Brazil
hcfmusp.description.articlenumbere0205791
hcfmusp.description.issue11
hcfmusp.description.volume13
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000449374000003
hcfmusp.origem.id2-s2.0-85056242578
hcfmusp.publisher.citySAN FRANCISCOeng
hcfmusp.publisher.countryUSAeng
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dc.description.indexMEDLINEeng
hcfmusp.citation.scopus33
hcfmusp.scopus.lastupdate2024-02-23-
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