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Title: Is Proflavine Exposure Associated with Disease Progression in Women with Cervical Dysplasia? A Brief Report
Authors: PANTANO, NaitielleHUNT, BradySCHWARZ, Richard A.PARRA, SoniaCHERRY, KatelinPOSSATI-RESENDE, Julio CesarLONGATTO-FILHO, AdhemarFREGNANI, Jose Humberto Tavares GuerreiroCASTLE, Philip E.SCHMELER, KathleenRICHARDS-KORTUM, Rebecca
Citation: PHOTOCHEMISTRY AND PHOTOBIOLOGY, v.94, n.6, p.1308-1313, 2018
Abstract: Proflavine is an acridine dye used with high-resolution microendoscopy for in vivo diagnostic evaluation of cervical epithelial cells. However, there are concerns that even short-term exposure of cervical tissue to dilute proflavine may increase cervical cancer risk. We performed a retrospective analysis of women referred for colposcopy to Barretos Cancer Hospital comparing the risk of cervical disease progression in those whose cervical tissue was (n = 232) or was not exposed (n = 160) to proflavine. Patients in both groups underwent treatment and follow-up based on histopathologic results and per the local standards of care. Progression of disease was evaluated by comparing histopathology from the initial visit to the worst subsequent histopathology result from all follow-up visits. Mean duration of follow-up was 18.7 and 20.1 months for the proflavine-exposed and controls groups, respectively. There were no significant differences in disease progression from normal/CIN1 to CIN2/3 or from any initial diagnosis to invasive cancer between the proflavine exposed and control groups overall. Risks of cervical dysplasia progression observed in this study are in agreement with those of the natural history of cervical cancer. Our results suggest that cervical exposure to dilute proflavine does not increase the risk of cervical precancer and cancer.
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Artigos e Materiais de Revistas Científicas - FM/Outros
Outros departamentos - FM/Outros

Artigos e Materiais de Revistas Científicas - IMT
Instituto de Medicina Tropical - IMT

Artigos e Materiais de Revistas Científicas - LIM/14
LIM/14 - Laboratório de Investigação em Patologia Hepática

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