Please use this identifier to cite or link to this item:
Title: Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer
Authors: HOADLEY, Katherine A.YAU, ChristinaHINOUE, ToshinoriWOLF, Denise M.LAZAR, Alexander J.DRILL, EstherSHEN, RonglaiTAYLOR, Alison M.CHERNIACK, Andrew D.THORSSON, VesteinnAKBANI, RehanBOWLBY, ReanneWONG, Christopher K.WIZNEROWICZ, MaciejSANCHEZ-VEGA, FranciscoROBERTSON, A. GordonSCHNEIDER, Barbara G.LAWRENCE, Michael S.NOUSHMEHR, HoutanMALTA, Tathiane M.STUART, Joshua M.BENZ, Christopher C.LAIRD, Peter W.
Citation: CELL, v.173, n.2, p.291-304.e6, 2018
Abstract: We conducted comprehensive integrative molecular analyses of the complete set of tumors in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and representing 33 types of cancer. We performed molecular clustering using data on chromosome-arm-level aneuploidy, DNA hypermethylation, mRNA, and miRNA expression levels and reverse-phase protein arrays, of which all, except for aneuploidy, revealed clustering primarily organized by histology, tissue type, or anatomic origin. The influence of cell type was evident in DNA-methylation-based clustering, even after excluding sites with known preexisting tissue-type-specific methylation. Integrative clustering further emphasized the dominant role of cell-of-origin patterns. Molecular similarities among histologically or anatomically related cancer types provide a basis for focused pan-cancer analyses, such as pan-gastrointestinal, pan-gynecological, pan-kidney, and pan-squamous cancers, and those related by stemness features, which in turn may inform strategies for future therapeutic development.
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/Outros
Outros departamentos - FM/Outros

Artigos e Materiais de Revistas Científicas - IMT
Instituto de Medicina Tropical - IMT

Artigos e Materiais de Revistas Científicas - LIM/14
LIM/14 - Laboratório de Investigação em Patologia Hepática

Files in This Item:
File Description SizeFormat 
art_HOADLEY_CellofOrigin_Patterns_Dominate_the_Molecular_Classification_of_10000_2018.PDFpublishedVersion (English)7.67 MBAdobe PDFThumbnail

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.