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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorDESIDERI, Debora
dc.contributor.authorZRENNER, Christoph
dc.contributor.authorGORDON, Pedro Caldana
dc.contributor.authorZIEMANN, Ulf
dc.contributor.authorBELARDINELLI, Paolo
dc.date.accessioned2019-01-17T13:37:09Z-
dc.date.available2019-01-17T13:37:09Z-
dc.date.issued2018
dc.identifier.citationPLOS ONE, v.13, n.12, article ID e0208747, 17p, 2018
dc.identifier.issn1932-6203
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/30104-
dc.description.abstractRepetitive transcranial magnetic stimulation (rTMS) can induce excitability changes of a stimulated brain area through synaptic plasticity mechanisms. High-frequency (100 Hz) triplets of rTMS synchronized to the negative but not the positive peak of the ongoing sensorimotor mu-rhythm isolated with the concurrently acquired electroencephalography (EEG) resulted in a reproducible long-term potentiation like increase of motor evoked potential (MEP) amplitude, an index of corticospinal excitability (Zrenner et al. 2018, Brain Stimul 11:374-389). Here, we analyzed the EEG and TMS-EEG data from (Zrenner et al., 2018) to investigate the effects of p-rhythm-phase-dependent burst-rTMS on EEG-based measures of cortical excitability. We used resting-state EEG to assess mu- and beta-power in the motor cortex ipsi- and contralateral to the stimulation, and single-pulse TMS-evoked and induced EEG responses in the stimulated motor cortex. We found that mu-rhythm-phase-dependent burst-rTMS did not significantly change any of these EEG measures, despite the presence of a significant differential and reproducible effect on MEP amplitude. We conclude that EEG measures of cortical excitability do not reflect corticospinal excitability as measured by MEP amplitude. Most likely this is explained by the fact that rTMS induces complex changes at the molecular and synaptic level towards both excitation and inhibition that cannot be differentiated at the macroscopic level by EEG.eng
dc.description.sponsorshipDFG [ZI 542/7-1]
dc.description.sponsorshipIndustry-on-Campus Grant [IoC 211]
dc.description.sponsorshipUniversity of Tubingen Fortune Junior Grant [2287-0-0]
dc.language.isoeng
dc.publisherPUBLIC LIBRARY SCIENCEeng
dc.relation.ispartofPlos One
dc.rightsopenAccesseng
dc.subject.othertranscranial magnetic stimulationeng
dc.subject.otherprimary motor cortexeng
dc.subject.othersynaptic plasticityeng
dc.subject.otheroscillatory activitieseng
dc.subject.othermodulationeng
dc.subject.otherpotentialseng
dc.subject.otherinsightseng
dc.titleNil effects of mu-rhythm phase-dependent burst-rTMS on cortical excitability in humans: A resting-state EEG and TMS-EEG studyeng
dc.typearticleeng
dc.rights.holderCopyright PUBLIC LIBRARY SCIENCEeng
dc.identifier.doi10.1371/journal.pone.0208747
dc.identifier.pmid30532205
dc.subject.wosMultidisciplinary Scienceseng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalDESIDERI, Debora:Univ Tubingen, Dept Neurol & Stroke, Tubingen, Germany; Univ Tubingen, Hertie Inst Clin Brain Res, Tubingen, Germany
hcfmusp.author.externalZRENNER, Christoph:Univ Tubingen, Dept Neurol & Stroke, Tubingen, Germany; Univ Tubingen, Hertie Inst Clin Brain Res, Tubingen, Germany
hcfmusp.author.externalZIEMANN, Ulf:Univ Tubingen, Dept Neurol & Stroke, Tubingen, Germany; Univ Tubingen, Hertie Inst Clin Brain Res, Tubingen, Germany
hcfmusp.author.externalBELARDINELLI, Paolo:Univ Tubingen, Dept Neurol & Stroke, Tubingen, Germany; Univ Tubingen, Hertie Inst Clin Brain Res, Tubingen, Germany
hcfmusp.description.articlenumbere0208747
hcfmusp.description.issue12
hcfmusp.description.volume13
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000452640900039
hcfmusp.origem.id2-s2.0-85058130334
hcfmusp.publisher.citySAN FRANCISCOeng
hcfmusp.publisher.countryUSAeng
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dc.description.indexMEDLINEeng
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