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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | CHEN, Han | |
dc.contributor.author | LI, Chunyan | |
dc.contributor.author | PENG, Xinxin | |
dc.contributor.author | ZHOU, Zhicheng | |
dc.contributor.author | WEINSTEIN, John N. | |
dc.contributor.author | LIANG, Han | |
dc.date.accessioned | 2019-01-17T13:37:11Z | |
dc.date.available | 2019-01-17T13:37:11Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | CELL, v.173, n.2, p.386-399.e12, 2018 | |
dc.identifier.issn | 0092-8674 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/30108 | |
dc.description.abstract | The role of enhancers, a key class of non-coding regulatory DNA elements, in cancer development has increasingly been appreciated. Here, we present the detection and characterization of a large number of expressed enhancers in a genome-wide analysis of 8928 tumor samples across 33 cancer types using TCGA RNA-seq data. Compared with matched normal tissues, global enhancer activation was observed in most cancers. Across cancer types, global enhancer activity was positively associated with aneuploidy, but not mutation load, suggesting a hypothesis centered on ""chromatin-state'' to explain their interplay. Integrating eQTL, mRNA co-expression, and Hi-C data analysis, we developed a computational method to infer causal enhancer-gene interactions, revealing enhancers of clinically actionable genes. Having identified an enhancer similar to 140 kb downstream of PD-L1, a major immunotherapy target, we validated it experimentally. This study provides a systematic view of enhancer activity in diverse tumor contexts and suggests the clinical implications of enhancers. | eng |
dc.description.sponsorship | U.S. National Institutes of Health [CA175486, CA209851, CA016672] | |
dc.description.sponsorship | Cancer Prevention and Research Institute of Texas [RP140462] | |
dc.description.sponsorship | University of Texas System STARS award | |
dc.description.sponsorship | Gulf Coast Consortia on the NLM Training Program in Biomedical Informatics and Data Science [T15 LM007093] | |
dc.description.sponsorship | CAS-Sponsored Scholarship Program for Visiting Scholars [2015-40] | |
dc.language.iso | eng | |
dc.publisher | CELL PRESS | eng |
dc.relation.ispartof | Cell | |
dc.rights | openAccess | eng |
dc.subject.other | human genome | eng |
dc.subject.other | transcriptional enhancers | eng |
dc.subject.other | gene-expression | eng |
dc.subject.other | super-enhancers | eng |
dc.subject.other | class discovery | eng |
dc.subject.other | noncoding rna | eng |
dc.subject.other | human-cells | eng |
dc.subject.other | landscape | eng |
dc.subject.other | map | eng |
dc.subject.other | identification | eng |
dc.title | A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples | eng |
dc.type | article | eng |
dc.rights.holder | Copyright CELL PRESS | eng |
dc.contributor.groupauthor | Canc Genome Atlas Res Network | |
dc.contributor.groupauthor | LONGATTO-FILHO, Adhemar | |
dc.identifier.doi | 10.1016/j.cell.2018.03.027 | |
dc.identifier.pmid | 29625054 | |
dc.subject.wos | Biochemistry & Molecular Biology | eng |
dc.subject.wos | Cell Biology | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | CHEN, Han:Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA | |
hcfmusp.author.external | LI, Chunyan:Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA; Chinese Acad Sci, Key Lab Genom & Precis Med, Gastrointestinal Canc Res Ctr, Beijing Inst Genom, Beijing 100101, Peoples R China | |
hcfmusp.author.external | PENG, Xinxin:Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA | |
hcfmusp.author.external | ZHOU, Zhicheng:Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA; Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77030 USA | |
hcfmusp.author.external | WEINSTEIN, John N.:Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA; Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77030 USA | |
hcfmusp.author.external | LIANG, Han:Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA; Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77030 USA | |
hcfmusp.description.articlenumber | 399.e1 | |
hcfmusp.description.beginpage | 386 | |
hcfmusp.description.endpage | 399.e12 | |
hcfmusp.description.issue | 2 | |
hcfmusp.description.volume | 173 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000429320200013 | |
hcfmusp.origem.id | 2-s2.0-85044921094 | |
hcfmusp.publisher.city | CAMBRIDGE | eng |
hcfmusp.publisher.country | USA | eng |
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dc.description.index | MEDLINE | eng |
dc.identifier.eissn | 1097-4172 | |
hcfmusp.citation.scopus | 183 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/Outros Artigos e Materiais de Revistas Científicas - IMT Artigos e Materiais de Revistas Científicas - LIM/14 Artigos e Materiais de Revistas Científicas - ODS/03 |
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art_CHEN_A_PanCancer_Analysis_of_Enhancer_Expression_in_Nearly_2018.PDF | publishedVersion (English) | 4.66 MB | Adobe PDF | View/Open |
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