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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLIU, Jianfang
dc.contributor.authorLICHTENBERG, Tara
dc.contributor.authorHOADLEY, Katherine A.
dc.contributor.authorPOISSON, Laila M.
dc.contributor.authorLAZAR, Alexander J.
dc.contributor.authorCHERNIACK, Andrew D.
dc.contributor.authorKOVATICH, Albert J.
dc.contributor.authorBENZ, Christopher C.
dc.contributor.authorLEVINE, Douglas A.
dc.contributor.authorLEE, Adrian V.
dc.contributor.authorOMBERG, Larsson
dc.contributor.authorWOLF, Denise M.
dc.contributor.authorSHRIVER, Craig D.
dc.contributor.authorTHORSSON, Vesteinn
dc.contributor.authorHU, Hai
dc.identifier.citationCELL, v.173, n.2, p.400-416.e11, 2018
dc.description.abstractFor a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale.eng
dc.description.sponsorshipU.S. Department of Defense through the Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-12-2-0050, HU0001-16-2-0004]
dc.description.sponsorshipTCGA [U54 HG003273, U54 HG003067, U54 HG003079, U24 CA143799, U24 CA143835, U24 CA143840, U24 CA143843, U24 CA143845, U24 CA143848, U24 CA143858, U24 CA143866, U24 CA143867, U24 CA143882, U24 CA143883, U24 CA144025, P30 CA016672]
dc.publisherCELL PRESSeng
dc.subject.othercomprehensive genomic characterizationeng
dc.subject.otherprogression-free survivaleng
dc.subject.othersufficient follow-upeng
dc.subject.otherhuman breast-tumorseng
dc.subject.othermolecular portraitseng
dc.titleAn Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analyticseng
dc.rights.holderCopyright CELL PRESSeng
dc.contributor.groupauthorCanc Genome Atlas Res Network
dc.contributor.groupauthorLONGATTO-FILHO, Adhemar
dc.subject.wosBiochemistry & Molecular Biologyeng
dc.subject.wosCell Biologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Jianfang:Chan Soon Shiong Inst Mol Med Windber, Windber, PA 15963 USA, Tara:Nationwide Childrens Hosp, Columbus, OH 43205 USA, Katherine A.:Univ North Carolina Chapel Hill, Lineberger Comprehens Canc Ctr, Dept Genet, Chapel Hill, NC 27599 USA, Laila M.:Henry Ford Hlth Syst, Henry Ford Canc Inst, Detroit, MI 48202 USA; Henry Ford Hlth Syst, Hermelin Brain Tumor Ctr, Detroit, MI 48202 USA, Alexander J.:Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA; Univ Texas MD Anderson Canc Ctr, Dept Genom Med, Houston, TX 77030 USA; Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, Houston, TX 77030 USA, Andrew D.:Eli & Edythe L Broad Inst MIT & Harvard, Cambridge, MA 02142 USA, Albert J.:Uniformed Serv Univ Hlth Sci, Walter Reed Natl Mil Med Ctr, Murtha Canc Ctr, Clin Breast Care Project, Bethesda, MD 20889 USA, Christopher C.:Buck Inst Res Aging, Novato, CA 94945 USA, Douglas A.:NYU, Langone Med Ctr, Dept OB GYN, Div Gynecol Oncol, New York, NY 10016 USA, Adrian V.:Univ Pittsburgh, Womens Canc Res Ctr, Dept Pharmacol & Chem Biol & Human Genet, UPMC Hillman Canc Ctr, Pittsburgh, PA 15213 USA; Magee Womens Res Inst, Pittsburgh, PA 15213 USA, Larsson:Sage Bionetworks, Seattle, WA 98109 USA, Denise M.:Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA, Craig D.:Uniformed Serv Univ Hlth Sci, Walter Reed Natl Mil Med Ctr, Murtha Canc Ctr, Bethesda, MD 20889 USA, Vesteinn:Inst Syst Biol, Seattle, WA 98109 USA, Hai:Chan Soon Shiong Inst Mol Med Windber, Windber, PA 15963 USA
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Artigos e Materiais de Revistas Científicas - IMT
Instituto de Medicina Tropical - IMT

Artigos e Materiais de Revistas Científicas - LIM/14
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ODS/03 - Saúde e bem-estar

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