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Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/30121
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorRICKETTS, Christopher J.
dc.contributor.authorCUBAS, Aguirre A. de
dc.contributor.authorFAN, Huihui
dc.contributor.authorSMITH, Christof C.
dc.contributor.authorLANG, Martin
dc.contributor.authorREZNIK, Ed
dc.contributor.authorBOWLBY, Reanne
dc.contributor.authorGIBB, Ewan A.
dc.contributor.authorAKBANI, Rehan
dc.contributor.authorBEROUKHIM, Rameen
dc.contributor.authorBOTTARO, Donald P.
dc.contributor.authorCHOUEIRI, Toni K.
dc.contributor.authorGIBBS, Richard A.
dc.contributor.authorGODWIN, Andrew K.
dc.contributor.authorHAAKE, Scott
dc.contributor.authorHAKIMI, A. Ari
dc.contributor.authorHENSKE, Elizabeth P.
dc.contributor.authorHSIEH, James J.
dc.contributor.authorHO, Thai H.
dc.contributor.authorKANCHI, Rupa S.
dc.contributor.authorKRISHNAN, Bhavani
dc.contributor.authorKWAITKOWSKI, David J.
dc.contributor.authorLUI, Wembin
dc.contributor.authorMERINO, Maria J.
dc.contributor.authorMILLS, Gordon B.
dc.contributor.authorMYERS, Jerome
dc.contributor.authorNICKERSON, Michael L.
dc.contributor.authorREUTER, Victor E.
dc.contributor.authorSCHMIDT, Laura S.
dc.contributor.authorSHELLEY, C. Simon
dc.contributor.authorSHEN, Hui
dc.contributor.authorSHUCH, Brian
dc.contributor.authorSIGNORETTI, Sabina
dc.contributor.authorSRINIVASAN, Ramaprasad
dc.contributor.authorTAMBOLI, Pheroze
dc.contributor.authorTHOMAS, George
dc.contributor.authorVINCENT, Benjamin G.
dc.contributor.authorVOCKE, Cathy D.
dc.contributor.authorWHEELER, David A.
dc.contributor.authorYANG, Lixing
dc.contributor.authorKIM, William T.
dc.contributor.authorROBERTSON, A. Gordon
dc.contributor.authorSPELLMAN, Paul T.
dc.contributor.authorRATHMELL, W. Kimryn
dc.contributor.authorLINEHAN, W. Marston
dc.date.accessioned2019-01-17T13:37:16Z
dc.date.available2019-01-17T13:37:16Z
dc.date.issued2018
dc.identifier.citationCELL REPORTS, v.23, n.1, p.313-326.e5, 2018
dc.identifier.issn2211-1247
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/30121
dc.description.abstractRenal cell carcinoma(RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers. Somatic alteration of BAP1, PBRM1, and PTEN and altered metabolic pathways correlated with subtype-specific decreased survival, while CDKN2A alteration, increased DNA hypermethylation, and increases in the immune-related Th2 gene expression signature correlated with decreased survival within all major histologic subtypes. CIMP-RCC demonstrated an increased immune signature, and a uniform and distinct metabolic expression pattern identified a subset of metabolically divergent (MD) ChRCC that associated with extremely poor survival.eng
dc.description.sponsorshipNIH Genome sequencing center [U54 HG003273, U54 HG003067, U54 HG003079]
dc.description.sponsorshipNIH Genome data analysis center and genome characterization center [U24 CA143799, U24 CA143835, U24 CA143840, U24 CA143843, U24 CA143845, U24 CA143848, U24 CA143858, U24 CA143866, U24 CA143867, U24 CA143882, U24 CA143883, U24 CA144025]
dc.description.sponsorshipNIH PCC grant [P30 CA016672]
dc.description.sponsorshipFrederick National Laboratory for Cancer Research, NIH [HHSN261200800001E]
dc.language.isoeng
dc.publisherCELL PRESSeng
dc.relation.ispartofCell Reports
dc.rightsopenAccesseng
dc.subject.othersomatic point mutationseng
dc.subject.othersequencing dataeng
dc.subject.otherrna-seqeng
dc.subject.otherclass discoveryeng
dc.subject.othermessenger-rnaeng
dc.subject.otherkidney cancereng
dc.subject.othergenetic-basiseng
dc.subject.otherexpressioneng
dc.subject.otherbreasteng
dc.subject.otherdnaeng
dc.titleThe Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinomaeng
dc.typearticleeng
dc.rights.holderCopyright CELL PRESSeng
dc.contributor.groupauthorCanc Genome Atlas Res Network
dc.contributor.groupauthorLONGATTO-FILHO, Adhemar
dc.identifier.doi10.1016/j.celrep.2018.03.075
dc.identifier.pmid29617669
dc.subject.wosCell Biologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalRICKETTS, Christopher J.:NCI, Urol Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA
hcfmusp.author.externalCUBAS, Aguirre A. de:Vanderbilt Univ, Sch Med, Nashville, TN 37232 USA
hcfmusp.author.externalFAN, Huihui:Van Andel Res Inst, Grand Rapids, MI 49503 USA
hcfmusp.author.externalSMITH, Christof C.:Univ North Carolina Chapel Hill, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
hcfmusp.author.externalLANG, Martin:NCI, Urol Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA
hcfmusp.author.externalREZNIK, Ed:Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
hcfmusp.author.externalBOWLBY, Reanne:Canadas Michael Smith Genome Sci Ctr, Vancouver, BC V5Z 4S6, Canada
hcfmusp.author.externalGIBB, Ewan A.:Canadas Michael Smith Genome Sci Ctr, Vancouver, BC V5Z 4S6, Canada
hcfmusp.author.externalAKBANI, Rehan:Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
hcfmusp.author.externalBEROUKHIM, Rameen:Broad Inst Massachusetts Inst Technol & Harvard U, Cambridge, MA 02142 USA
hcfmusp.author.externalBOTTARO, Donald P.:NCI, Urol Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA
hcfmusp.author.externalCHOUEIRI, Toni K.:Dana Farber Canc Inst, Boston, MA 02215 USA
hcfmusp.author.externalGIBBS, Richard A.:Baylor Coll Med, Houston, TX 77030 USA
hcfmusp.author.externalGODWIN, Andrew K.:Univ Kansas, Med Ctr, Kansas City, KS 66206 USA
hcfmusp.author.externalHAAKE, Scott:Vanderbilt Univ, Sch Med, Nashville, TN 37232 USA
hcfmusp.author.externalHAKIMI, A. Ari:Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
hcfmusp.author.externalHENSKE, Elizabeth P.:Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA
hcfmusp.author.externalHSIEH, James J.:Washington Univ, Sch Med, St Louis, MO 63110 USA
hcfmusp.author.externalHO, Thai H.:Mayo Clin Arizona, Phoenix, AZ 85054 USA
hcfmusp.author.externalKANCHI, Rupa S.:Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
hcfmusp.author.externalKRISHNAN, Bhavani:Univ North Carolina Chapel Hill, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
hcfmusp.author.externalKWAITKOWSKI, David J.:Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA
hcfmusp.author.externalLUI, Wembin:Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
hcfmusp.author.externalMERINO, Maria J.:NCI, Lab Pathol, Ctr Canc Res, Bethesda, MD 20892 USA
hcfmusp.author.externalMILLS, Gordon B.:Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
hcfmusp.author.externalMYERS, Jerome:Centura Hlth, Centennial, CO 80112 USA
hcfmusp.author.externalNICKERSON, Michael L.:NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
hcfmusp.author.externalREUTER, Victor E.:Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
hcfmusp.author.externalSCHMIDT, Laura S.:NCI, Urol Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA; Leidos Biomed Res Inc, Basic Sci Program, Frederick Natl Lab Canc Res, Frederick, MD 21702 USA
hcfmusp.author.externalSHELLEY, C. Simon:Leukemia Therapeut LLC, Hull, MA 02045 USA
hcfmusp.author.externalSHEN, Hui:Van Andel Res Inst, Grand Rapids, MI 49503 USA
hcfmusp.author.externalSHUCH, Brian:Yale Univ, New Haven, CT 06520 USA
hcfmusp.author.externalSIGNORETTI, Sabina:Dana Farber Canc Inst, Boston, MA 02215 USA
hcfmusp.author.externalSRINIVASAN, Ramaprasad:NCI, Urol Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA
hcfmusp.author.externalTAMBOLI, Pheroze:Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
hcfmusp.author.externalTHOMAS, George:Oregon Hlth & Sci Univ, Portland, OR 97239 USA
hcfmusp.author.externalVINCENT, Benjamin G.:Univ North Carolina Chapel Hill, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
hcfmusp.author.externalVOCKE, Cathy D.:NCI, Urol Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA
hcfmusp.author.externalWHEELER, David A.:Baylor Coll Med, Houston, TX 77030 USA
hcfmusp.author.externalYANG, Lixing:Harvard Med Sch, Boston, MA 02115 USA
hcfmusp.author.externalKIM, William T.:Univ North Carolina Chapel Hill, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
hcfmusp.author.externalROBERTSON, A. Gordon:Canadas Michael Smith Genome Sci Ctr, Vancouver, BC V5Z 4S6, Canada
hcfmusp.author.externalSPELLMAN, Paul T.:Oregon Hlth & Sci Univ, Portland, OR 97239 USA
hcfmusp.author.externalRATHMELL, W. Kimryn:Vanderbilt Univ, Sch Med, Nashville, TN 37232 USA
hcfmusp.author.externalLINEHAN, W. Marston:NCI, Urol Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA
hcfmusp.description.beginpage313
hcfmusp.description.endpage326.e5
hcfmusp.description.issue1
hcfmusp.description.volume23
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000429092900026
hcfmusp.origem.id2-s2.0-85044860979
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hcfmusp.publisher.countryUSAeng
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