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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLIMA, Tatiana Megale De
dc.contributor.authorFOCCHI, Gustavo Rubino De Azevedo
dc.contributor.authorALMEIDA, Bruna Cristine De
dc.contributor.authorBELFORT-MATTOS, Patricia Napoli
dc.contributor.authorHEINKE, Thais
dc.contributor.authorSPECK, Neila Maria De Gois
dc.date.accessioned2019-01-17T13:37:18Z-
dc.date.available2019-01-17T13:37:18Z-
dc.date.issued2018
dc.identifier.citationANTICANCER RESEARCH, v.38, n.12, p.6673-6681, 2018
dc.identifier.issn0250-7005
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/30130-
dc.description.abstractAim: To evaluate cyclin-dependent kinase inhibitor 2A (CDKN2A) and cytokeratin 7 (CK7) expression in cervical intraepithelial neoplasia (CIN) formalin-fixed samples. Materials and Methods: Staining with antibody clones G175-405 for CDKN2A and OV-TL 12/30 for CK7 were evaluated and the detection of protein expressions were compared in 147 patients with CIN. Results: Clinical follow-up of patients with CIN1 and CIN2 showed that most patients had a favorable outcome. Single CDKN2A or CK7 expression and their combined expression had a greater sensitivity and negative predictive value in CIN1, corresponding to the non-development of the disease. The positive predictive value of CDKN2A was greater than that of CK7. Combined expression of CDKN2A and CK7 showed that the sensitivity, specificity, positive predictive values, and negative predictive values had their maximum index in the CIN1 group. Analysis of combined expression of CDKN2A and CK7 showed that 85.7% of patients presented unfavorable clinical outcomes, with positive expression for both markers identified in CIN2 Conclusion: Combined expression of CK7 and CDKN2A was associated with a better diagnosis of CIN, and negative expression in CIN112 groups had a greater negative predictive value for patient clinical outcome.eng
dc.description.sponsorshipCAPES - Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
dc.language.isoeng
dc.publisherINT INST ANTICANCER RESEARCHeng
dc.relation.ispartofAnticancer Research
dc.rightsrestrictedAccesseng
dc.subjectCDKN2Aeng
dc.subjectp16 expressioneng
dc.subjectCK7 expressioneng
dc.subjectCINeng
dc.subjectimmunohistochemistryeng
dc.subjectcervical cancereng
dc.subject.otheramerican societyeng
dc.subject.otherp16eng
dc.subject.otherimmunohistochemistryeng
dc.subject.otherlesionseng
dc.subject.othertissueeng
dc.subject.otherprogressioneng
dc.subject.othercolposcopyeng
dc.subject.otherpreventioneng
dc.subject.otherbiomarkereng
dc.subject.othermarkereng
dc.titleExpression of CK7 and CDKN2 in Cervical Intraepithelial Neoplasia and Correlation with Clinical Outcomeeng
dc.typearticleeng
dc.rights.holderCopyright INT INST ANTICANCER RESEARCHeng
dc.identifier.doi10.21873/anticanres.13035
dc.identifier.pmid30504376
dc.subject.wosOncologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalLIMA, Tatiana Megale De:Univ Fed Sao Paulo, Dept Gynecol, Gynecol Dis Prevent Nucleus NUPREV, Sao Paulo, Brazil
hcfmusp.author.externalFOCCHI, Gustavo Rubino De Azevedo:Univ Fed Sao Paulo, Dept Pathol, Sao Paulo, Brazil
hcfmusp.author.externalBELFORT-MATTOS, Patricia Napoli:Univ Fed Sao Paulo, Dept Gynecol, Gynecol Dis Prevent Nucleus NUPREV, Sao Paulo, Brazil
hcfmusp.author.externalHEINKE, Thais:Univ Fed Sao Paulo, Dept Pathol, Sao Paulo, Brazil
hcfmusp.author.externalSPECK, Neila Maria De Gois:Univ Fed Sao Paulo, Dept Gynecol, Gynecol Dis Prevent Nucleus NUPREV, Sao Paulo, Brazil
hcfmusp.description.beginpage6673
hcfmusp.description.endpage6681
hcfmusp.description.issue12
hcfmusp.description.volume38
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000451742800010
hcfmusp.origem.id2-s2.0-85057554798
hcfmusp.publisher.cityATHENSeng
hcfmusp.publisher.countryGREECEeng
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dc.description.indexMEDLINEeng
dc.identifier.eissn1791-7530
hcfmusp.citation.scopus4-
hcfmusp.scopus.lastupdate2022-06-10-
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