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Title: CKD-MBD: from the Pathogenesis to the Identification and Development of Potential Novel Therapeutic Targets
Authors: ELIAS, Rosilene MottaDALBONI, Maria AparecidaCOELHO, Ana Carolina E.MOYSES, Rosa M. A.
Citation: CURRENT OSTEOPOROSIS REPORTS, v.16, n.6, p.693-702, 2018
Abstract: Purpose of ReviewAlthough we have seen tremendous advances in the comprehension of CKD-MBD pathophysiology during the last few years, this was not accompanied by a significant change in mortality rate and quality of life. This review will address the traditional and updated pathophysiology of CKD-MBD along with the therapeutic limitations that affect CKD-MBD and proposed alternative treatment targets.Recent FindingsAn innovative concept brings the osteocyte to the center of CKD-MBD pathophysiology, in contrast to the traditional view of the skeleton as a target organ for disturbances in calcium, phosphate, parathyroid hormone, and vitamin D. Osteocytes, through the synthesis of FGF-23, sclerostin, among others, are able to interact with other organs, making bone an endocrine organ. Thus, osteocyte dysregulation might be an early event during the course of CKD.SummaryThis review will revisit general concepts on the pathophysiology of CKD-MBD and discuss new perspectives for its treatment.
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Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/16
LIM/16 - Laboratório de Fisiopatologia Renal

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

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