Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/30190
Title: Diagnostic and Prognostic Impact of pc-ASPECTS Applied to Perfusion CT in the Basilar Artery International Cooperation Study
Authors: PALLESEN, Lars-PederGERBER, JohannesDZIALOWSKI, ImanuelHOEVEN, Erik J. R. J. van derMICHEL, PatrikPFEFFERKORN, ThomasOZDOBA, ChristophKAPPELLE, L. JaapWIEDEMANN, BaerbelKHOMENKO, AndreiALGRA, AleHILL, Michael D.KUMMER, Ruediger vonDEMCHUK, Andrew M.SCHONEWILLE, Wouter J.PUETZ, Volker
Citation: JOURNAL OF NEUROIMAGING, v.25, n.3, p.384-389, 2015
Abstract: BACKGROUND AND PURPOSEThe posterior circulation Acute Stroke Prognosis Early CT Score (pc-APECTS) applied to CT angiography source images (CTA-SI) predicts the functional outcome of patients in the Basilar Artery International Cooperation Study (BASICS). We assessed the diagnostic and prognostic impact of pc-ASPECTS applied to perfusion CT (CTP) in the BASICS registry population. METHODSWe applied pc-ASPECTS to CTA-SI and cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) parameter maps of BASICS patients with CTA and CTP studies performed. Hypoattenuation on CTA-SI, relative reduction in CBV or CBF, or relative increase in MTT were rated as abnormal. RESULTSCTA and CTP were available in 27/592 BASICS patients (4.6%). The proportion of patients with any perfusion abnormality was highest for MTT (93%; 95% confidence interval [CI], 76%-99%), compared with 78% (58%-91%) for CTA-SI and CBF, and 46% (27%-67%) for CBV (P < .001). All 3 patients with a CBV pc-ASPECTS < 8 compared to 6/23 patients with a CBV pc-ASPECTS 8 had died at 1 month (RR 3.8; 95% CI, 1.9-7.6). CONCLUSIONCTP was performed in a minority of the BASICS registry population. Perfusion disturbances in the posterior circulation were most pronounced on MTT parameter maps. CBV pc-ASPECTS < 8 may indicate patients with high case fatality.
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Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/15
LIM/15 - Laboratório de Investigação em Neurologia

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


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