Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/30230
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSHIMOJO, Guilherme Lemos
dc.contributor.authorDIAS, Danielle da Silva
dc.contributor.authorMALFITANO, Christiane
dc.contributor.authorSANCHES, Iris Callado
dc.contributor.authorLLESUY, Susana
dc.contributor.authorULLOA, Luis
dc.contributor.authorIRIGOYEN, Maria-Claudia
dc.contributor.authorANGELIS, Katia De
dc.date.accessioned2019-01-17T13:40:03Z
dc.date.available2019-01-17T13:40:03Z
dc.date.issued2018
dc.identifier.citationFRONTIERS IN PHYSIOLOGY, v.9, article ID 1471, 11p, 2018
dc.identifier.issn1664-042X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/30230
dc.description.abstractThe prevalence of hypertension sharply increases in menopausal women. Recent studies have demonstrated that aerobic or resistance training may help control hypertension. In this study, we report that combining aerobic and resistance training may provide an effective therapeutic approach for hypertension control, attenuating inflammation and oxidative stress in ovariectomized rats. Female Wistar and spontaneous hypertensive rats (SHR) were distributed into four groups: sedentary control (C), sedentary hypertensive (HR), sedentary hypertensive ovariectomized (HRO), and combined trained hypertensive ovariectomized (T-HR-O). Combined exercise training was performed on a motor treadmill (aerobic training) and on a ladder adapted to rats (resistance training), in alternate days for 8 weeks. Direct arterial pressure was recorded and oxidative stress and inflammation were evaluated in cardiac and renal tissue. Ovariectomy increases increased mean arterial blood pressure, sympathetic modulation, and oxidative stress in SHR. Combining aerobic and resistance training reduced mean arterial blood pressure (12% vs. HR-O), heart rate (8% vs. HR-O), vascular sympathetic modulation (40% vs. HR-O), and improved baroreflex sensitivity. Combined training reduced cardiac inflammation (TNF and IL-6) and cardiac and renal lipoperoxidation (59% and 57%, respectively vs. HR-O). It also enhanced cardiac (71%) and renal (76%) total antioxidant capacity when compared to HRO group. In conclusion, combining aerobic and resistance training improves mean arterial blood pressure, cardiovascular autonomic control, preventing cardiac and renal oxidative stress and inflammation in an experimental hypertension model with surgical menopause induced with ovariectomy.eng
dc.description.sponsorshipFundacao de Amparo e Pesquisa do Estado de Sao Paulo [FAPESP: 2018/20419-0, 2015/22113-6, 2011/16441-0]
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipCAPES [88881.062178/2014-01]
dc.description.sponsorshipCNPq-BPQ fellowships
dc.language.isoeng
dc.publisherFRONTIERS MEDIA SAeng
dc.relation.ispartofFrontiers in Physiology
dc.rightsopenAccesseng
dc.subjectcombined exercise trainingeng
dc.subjectovariectomyeng
dc.subjecthypertensioneng
dc.subjectcardiovascular autonomic dysfunctioneng
dc.subjectoxidative stresseng
dc.subjectinflammationeng
dc.subjectkidneyeng
dc.subject.otherregulating oxidative stresseng
dc.subject.otheramerican-heart-associationeng
dc.subject.otherovariectomized ratseng
dc.subject.otherpostmenopausal womeneng
dc.subject.othertnf-alphaeng
dc.subject.otheratherosclerosiseng
dc.subject.otherdysfunctioneng
dc.subject.othermetabolismeng
dc.subject.otherinterplayeng
dc.subject.otherbenefitseng
dc.titleCombined Aerobic and Resistance Exercise Training Improve Hypertension Associated With Menopauseeng
dc.typearticleeng
dc.rights.holderCopyright FRONTIERS MEDIA SAeng
dc.identifier.doi10.3389/fphys.2018.01471
dc.identifier.pmid30420811
dc.subject.wosPhysiologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalSHIMOJO, Guilherme Lemos:Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, Brazil
hcfmusp.author.externalDIAS, Danielle da Silva:Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, Brazil
hcfmusp.author.externalMALFITANO, Christiane:Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, Brazil
hcfmusp.author.externalSANCHES, Iris Callado:Univ Sao Judas Tadeu, Human Movement Lab, Sao Paulo, Brazil
hcfmusp.author.externalLLESUY, Susana:Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, Brazil; Univ Buenos Aires, Fac Farm & Bioquim, Dept Quim Analit & Fis Quim, Buenos Aires, DF, Argentina
hcfmusp.author.externalULLOA, Luis:Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, Brazil; Rutgers State Univ, Rutgers New Jersey Med Sch, Dept Surg, Ctr Immunol & Inflammat, Newark, NJ USA
hcfmusp.author.externalANGELIS, Katia De:Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, Brazil; Univ Fed Sao Paulo, Dept Physiol, Sao Paulo, Brazil
hcfmusp.description.articlenumber1471
hcfmusp.description.volume9
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000448543900001
hcfmusp.origem.id2-s2.0-85056118876
hcfmusp.publisher.cityLAUSANNEeng
hcfmusp.publisher.countrySWITZERLANDeng
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hcfmusp.citation.scopus19-
hcfmusp.scopus.lastupdate2023-01-12-
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