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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSHIMOJO, Guilherme Lemos
dc.contributor.authorDIAS, Danielle da Silva
dc.contributor.authorMALFITANO, Christiane
dc.contributor.authorSANCHES, Iris Callado
dc.contributor.authorLLESUY, Susana
dc.contributor.authorULLOA, Luis
dc.contributor.authorIRIGOYEN, Maria-Claudia
dc.contributor.authorANGELIS, Katia De
dc.identifier.citationFRONTIERS IN PHYSIOLOGY, v.9, article ID 1471, 11p, 2018
dc.description.abstractThe prevalence of hypertension sharply increases in menopausal women. Recent studies have demonstrated that aerobic or resistance training may help control hypertension. In this study, we report that combining aerobic and resistance training may provide an effective therapeutic approach for hypertension control, attenuating inflammation and oxidative stress in ovariectomized rats. Female Wistar and spontaneous hypertensive rats (SHR) were distributed into four groups: sedentary control (C), sedentary hypertensive (HR), sedentary hypertensive ovariectomized (HRO), and combined trained hypertensive ovariectomized (T-HR-O). Combined exercise training was performed on a motor treadmill (aerobic training) and on a ladder adapted to rats (resistance training), in alternate days for 8 weeks. Direct arterial pressure was recorded and oxidative stress and inflammation were evaluated in cardiac and renal tissue. Ovariectomy increases increased mean arterial blood pressure, sympathetic modulation, and oxidative stress in SHR. Combining aerobic and resistance training reduced mean arterial blood pressure (12% vs. HR-O), heart rate (8% vs. HR-O), vascular sympathetic modulation (40% vs. HR-O), and improved baroreflex sensitivity. Combined training reduced cardiac inflammation (TNF and IL-6) and cardiac and renal lipoperoxidation (59% and 57%, respectively vs. HR-O). It also enhanced cardiac (71%) and renal (76%) total antioxidant capacity when compared to HRO group. In conclusion, combining aerobic and resistance training improves mean arterial blood pressure, cardiovascular autonomic control, preventing cardiac and renal oxidative stress and inflammation in an experimental hypertension model with surgical menopause induced with ovariectomy.eng
dc.description.sponsorshipFundacao de Amparo e Pesquisa do Estado de Sao Paulo [FAPESP: 2018/20419-0, 2015/22113-6, 2011/16441-0]
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipCAPES [88881.062178/2014-01]
dc.description.sponsorshipCNPq-BPQ fellowships
dc.publisherFRONTIERS MEDIA SAeng
dc.relation.ispartofFrontiers in Physiology
dc.subjectcombined exercise trainingeng
dc.subjectcardiovascular autonomic dysfunctioneng
dc.subjectoxidative stresseng
dc.subject.otherregulating oxidative stresseng
dc.subject.otherovariectomized ratseng
dc.subject.otherpostmenopausal womeneng
dc.titleCombined Aerobic and Resistance Exercise Training Improve Hypertension Associated With Menopauseeng
dc.rights.holderCopyright FRONTIERS MEDIA SAeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Guilherme Lemos:Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, Brazil, Danielle da Silva:Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, Brazil, Christiane:Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, Brazil, Iris Callado:Univ Sao Judas Tadeu, Human Movement Lab, Sao Paulo, Brazil, Susana:Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, Brazil; Univ Buenos Aires, Fac Farm & Bioquim, Dept Quim Analit & Fis Quim, Buenos Aires, DF, Argentina, Luis:Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, Brazil; Rutgers State Univ, Rutgers New Jersey Med Sch, Dept Surg, Ctr Immunol & Inflammat, Newark, NJ USA, Katia De:Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, Brazil; Univ Fed Sao Paulo, Dept Physiol, Sao Paulo, Brazil
hcfmusp.relation.referenceAEBI H, 1984, METHOD ENZYMOL, V105, P121eng
hcfmusp.relation.referenceBernardes N, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-26816-4eng
hcfmusp.relation.referenceBertagnolli M, 2006, J HYPERTENS, V24, P2437, DOI 10.1097/01.hjh.0000251905.08547.17eng
hcfmusp.relation.referenceBjorkbacka H, 2006, CURR OPIN LIPIDOL, V17, P527eng
hcfmusp.relation.referenceBRISTOW JD, 1969, J PHYSIOL-LONDON, V202, pP45eng
hcfmusp.relation.referenceBrochu M, 2009, J CLIN ENDOCR METAB, V94, P3226, DOI 10.1210/jc.2008-2706eng
hcfmusp.relation.referenceCeriello A, 2008, DIABETES CARE, V31, pS181, DOI 10.2337/dc08-s245eng
hcfmusp.relation.referenceChatterjee M, 2007, CELL MOL BIOL, V53, P84, DOI 10.1170/T779eng
hcfmusp.relation.referenceCorbi G, 2013, FRONT PHYSIOL, V4, DOI 10.3389/fphys.2013.00324eng
hcfmusp.relation.referenceCornelissen VA, 2013, J AM HEART ASSOC, V2, DOI 10.1161/JAHA.112.004473eng
hcfmusp.relation.referenceCrowley SD, 2014, ANTIOXID REDOX SIGN, V20, P102, DOI 10.1089/ars.2013.5258eng
hcfmusp.relation.referenceCutler JA, 2008, HYPERTENSION, V52, P818, DOI 10.1161/HYPERTENSIONAHA.108.113357eng
hcfmusp.relation.referenceda Palma RK, 2016, J APPL PHYSIOL, V121, P1032, DOI 10.1152/japplphysiol.00130.2016eng
hcfmusp.relation.referenceDhingra S, 2007, AM J PHYSIOL-HEART C, V293, pH3524, DOI 10.1152/ajpheart.00919.2007eng
hcfmusp.relation.referenceEvelson P, 2001, ARCH BIOCHEM BIOPHYS, V388, P261, DOI 10.1006/abbi.2001.2292eng
hcfmusp.relation.referenceFlues K, 2010, MATURITAS, V65, P267, DOI 10.1016/j.maturitas.2009.11.007eng
hcfmusp.relation.referenceGocmen AY, 2014, ANADOLU KARDIYOL DER, V14, P498, DOI 10.5152/akd.2014.4923eng
hcfmusp.relation.referenceGrans CF, 2014, ARQ BRAS CARDIOL, V103, P60, DOI 10.5935/abc.20140093eng
hcfmusp.relation.referenceHogarth AJ, 2011, J HYPERTENS, V29, P2167, DOI 10.1097/HJH.0b013e32834b8014eng
hcfmusp.relation.referenceIrigoyen MC, 2016, CURR HYPERTENS REP, V18, DOI 10.1007/s11906-016-0642-9eng
hcfmusp.relation.referenceIrigoyen MC, 2005, HYPERTENSION, V46, P998, DOI 10.1161/01.HYP.0000176238.90688.6beng
hcfmusp.relation.referenceKaur K, 2006, J MOL CELL CARDIOL, V41, P1023, DOI 10.1016/j.yjmcc.2006.08.005eng
hcfmusp.relation.referenceLOWRY OH, 1951, J BIOL CHEM, V193, P265eng
hcfmusp.relation.referenceMaranon RO, 2014, AM J PHYSIOL-REG I, V306, pR248, DOI 10.1152/ajpregu.00490.2013eng
hcfmusp.relation.referenceMasson GS, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094927eng
hcfmusp.relation.referenceMozaffarian D, 2016, CIRCULATION, V133, pE38, DOI 10.1161/CIR.0000000000000350eng
hcfmusp.relation.referenceOHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3eng
hcfmusp.relation.referencePan YX, 2007, HYPERTENSION, V49, P519, DOI 10.1161/01.HYP.0000256955.74461.93eng
hcfmusp.relation.referencePavlov VA, 2012, NAT REV ENDOCRINOL, V8, P743, DOI 10.1038/nrendo.2012.189eng
hcfmusp.relation.referencePescatello LS, 2004, MED SCI SPORT EXER, V36, P533, DOI 10.1249/01.MSS.0000115224.88514.3Aeng
hcfmusp.relation.referencePham-Huy Lien Ai, 2008, Int J Biomed Sci, V4, P89eng
hcfmusp.relation.referenceREZNICK AZ, 1994, METHOD ENZYMOL, V233, P357eng
hcfmusp.relation.referenceRodrigues B, 2007, CARDIOVASC DIABETOL, V6, DOI 10.1186/1475-2840-6-38eng
hcfmusp.relation.referenceSanches IC, 2014, INT J SPORTS MED, V35, P323, DOI 10.1055/s-0033-1351254eng
hcfmusp.relation.referenceSanches IC, 2012, MENOPAUSE, V19, P562, DOI 10.1097/gme.0b013e3182358c9ceng
hcfmusp.relation.referenceShimojo GL, 2015, BRAZ J MED BIOL RES, V48, P523, DOI 10.1590/1414-431X20154387eng
hcfmusp.relation.referenceSima AV, 2009, CELL TISSUE RES, V335, P191, DOI 10.1007/s00441-008-0678-5eng
hcfmusp.relation.referenceValko M, 2004, MOL CELL BIOCHEM, V266, P37, DOI 10.1023/B:MCBI.0000049134.69131.89eng
hcfmusp.relation.referenceWatson T, 2008, ANTIOXID REDOX SIGN, V10, P1079, DOI 10.1089/ars.2007.1998eng
hcfmusp.relation.referenceWilliams MA, 2007, CIRCULATION, V116, P572, DOI 10.1161/CIRCULATIONAHA.107.185214eng
hcfmusp.relation.referenceZaki ME, 2014, J OSTEOPOROS, DOI 10.1155/2014/702589eng
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LIM/59 - Laboratório de Biologia Celular

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