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https://observatorio.fm.usp.br/handle/OPI/3049
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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | PIAZZA, Fabrizio | - |
dc.contributor.author | GREENBERG, Steven M. | - |
dc.contributor.author | SAVOIARDO, Mario | - |
dc.contributor.author | GARDINETTI, Margherita | - |
dc.contributor.author | CHIAPPARINI, Luisa | - |
dc.contributor.author | RAICHER, Irina | - |
dc.contributor.author | SAKAGUCHI, Hideya | - |
dc.contributor.author | BRIOSCHI, Monica | - |
dc.contributor.author | BILLO, Giuseppe | - |
dc.contributor.author | COLOMBO, Antonio | - |
dc.contributor.author | LANZANI, Francesca | - |
dc.contributor.author | PISCOSQUITO, Giuseppe | - |
dc.contributor.author | CARRIERO, Maria R. | - |
dc.contributor.author | GIACCONE, Giorgio | - |
dc.contributor.author | TAGLIAVINI, Fabrizio | - |
dc.contributor.author | FERRARESE, Carlo | - |
dc.contributor.author | DIFRANCESCO, Jacopo C. | - |
dc.date.accessioned | 2013-10-11T21:30:27Z | - |
dc.date.available | 2013-10-11T21:30:27Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | JOURNAL OF NEUROIMMUNOLOGY, v.253, n.1-2, p.64-65, 2012 | - |
dc.identifier.issn | 0165-5728 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/3049 | - |
dc.description.abstract | Objective: Cerebral amyloid angiopathy (CAA) is characterized by the progressive deposition of amyloid-β (Aβ) protein in the walls of small/medium sized arteries of cerebral cortex and leptomeninges, representing an important cause of spontaneous intracerebral haemorrhage and cognitive impairment. A subgroup of CAA patients develop perivascular inflammation linked to the Aβ laden vessels, associated with vasogenic edema (VE) and to a rapid cognitive decline, leading to a condition known as CAA-related inflammation (CAA-ri). This syndrome has parallels with what observed in about 10% of patients affected by Alzheimer's disease (AD) who developed reversible VE after immunization with the anti-Aβ antibody bapineuzumab, where postmortem examination revealed inflammation and/or vasculitis associated with CAA, implying the discontinuation of therapeutic protocols. Recent MRI data have also shown that up to 17% of the treated patients have signs of VE directly related to the drug dose, even if in the absence of clinical correlates. Methods: thanks to a novel technique for the ultra sensitive evaluation (patent application pending), we followed the concentration of anti-Aβ antibodies in the CSF of 10 CAA-ri patient during the acute phase (acCAA-ri) and after the remission phase (rpCAA-ri), compared to 8 non-inflammatory CAA, 10 AD, 10 MS and 20 healthy control subjects. Results: we demonstrated that the concentration of anti-Aβ antibodies is specifically increased in the CSF of acCAA-ri patients, followed by a progressive reduction of their concentration after steroid treatment, accordingly to clinical-radiological improvements. Moreover, we observed a spontaneous decrease of these autoantibodies in rpCAA-ri patients without any immunosuppressant treatment, finally proving that the event is not secondary to an unspecific effect of treatment, but strictly related to disease progression. Conclusions: our data support the hypothesis that the pathogenesis of CAA-ri is caused by a specific autoimmune reaction against Aβ, directly mediated by anti-Aβ autoantibodies. Since an invasive procedure such as brain biopsy is still needed for a definite diagnosis of CAA-ri, the outcomes implied by anti-Aβ dosage in CSF may be proposed to support future targets for early diagnosis and follow-up, in association with clinical and radiological features, and as a surrogate biomarker for clinical trials of disease modifying therapies. | - |
dc.language.iso | eng | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.ispartof | Journal of Neuroimmunology | - |
dc.rights | restrictedAccess | - |
dc.title | Immune-mediated mechanisms in the pathogenesis of cerebral amyloid angiopathy-related inflammation and Alzheimer's disease: Role of anti-A beta auto-antibodies | - |
dc.type | conferenceObject | - |
dc.rights.holder | Copyright ELSEVIER SCIENCE BV | - |
dc.description.conferencedate | NOV 04-08, 2012 | - |
dc.description.conferencelocal | Boston - MA, EUA | - |
dc.description.conferencename | 11th International Congress of Neuroimmunology (ISNI) | - |
dc.subject.wos | Immunology | - |
dc.subject.wos | Neurosciences | - |
dc.type.category | meeting abstract | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | PIAZZA, Fabrizio:Univ Milano Bicocca, Neurobiol Lab, Dept Neurosci, Monza, Italy | - |
hcfmusp.author.external | GREENBERG, Steven M.:Harvard Univ, Sch Med, Dept Neurol, Hemorrhag Stroke Res Program,Massachusetts Gen Ho, Boston, MA 02115 USA | - |
hcfmusp.author.external | SAVOIARDO, Mario:Ist Neurol C Besta, Dept Neuroradiol, Milan, Italy | - |
hcfmusp.author.external | GARDINETTI, Margherita:Univ Milano Bicocca, Neurobiol Lab, Dept Neurosci, Monza, Italy | - |
hcfmusp.author.external | CHIAPPARINI, Luisa:Ist Neurol C Besta, Dept Neuroradiol, Milan, Italy | - |
hcfmusp.author.external | SAKAGUCHI, Hideya:Kumamoto Univ, Fac Life Sci, Dept Neurol, Kumamoto, Japan | - |
hcfmusp.author.external | BRIOSCHI, Monica:Osped Niguarda Ca Granda, Dept Neurosci, Milan, Italy | - |
hcfmusp.author.external | BILLO, Giuseppe:St Bortolo Hosp, Dept Neurol, Vicenza, Italy | - |
hcfmusp.author.external | COLOMBO, Antonio:Desio Hosp, Dept Neurol, Desio, Italy | - |
hcfmusp.author.external | LANZANI, Francesca:Desio Hosp, Dept Neurol, Desio, Italy | - |
hcfmusp.author.external | PISCOSQUITO, Giuseppe:Ist Neurol C Besta, Dept Neurol Sci, Milan, Italy | - |
hcfmusp.author.external | CARRIERO, Maria R.:Ist Neurol C Besta, Dept Cerebrovasc Dis, Milan, Italy | - |
hcfmusp.author.external | GIACCONE, Giorgio:Ist Neurol C Besta, Dept Neuropathol & Neurol, Milan, Italy | - |
hcfmusp.author.external | TAGLIAVINI, Fabrizio:Ist Neurol C Besta, Dept Neuropathol & Neurol, Milan, Italy | - |
hcfmusp.author.external | FERRARESE, Carlo:Univ Milano Bicocca, Neurobiol Lab, Dept Neurosci, Monza, Italy | - |
hcfmusp.author.external | DIFRANCESCO, Jacopo C.:Univ Milano Bicocca, Neurobiol Lab, Dept Neurosci, Monza, Italy | - |
hcfmusp.description.beginpage | 64 | - |
hcfmusp.description.endpage | 65 | - |
hcfmusp.description.issue | 1-2 | - |
hcfmusp.description.volume | 253 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000312764800172 | - |
hcfmusp.publisher.city | AMSTERDAM | - |
hcfmusp.publisher.country | NETHERLANDS | - |
dc.description.index | MEDLINE | - |
Appears in Collections: | Comunicações em Eventos - HC/ICESP |
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