Panniculitis in childhood-onset systemic lupus erythematosus: a multicentric cohort study

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author VERDIER, Monica FMUSP-HC
ANUARDO, Pedro FMUSP-HC
GORMEZANO, Natali Weniger Spelling FMUSP-HC
ROMITI, Ricardo FMUSP-HC
CAMPOS, Lucia Maria Arruda FMUSP-HC
AIKAWA, Nadia Emi FMUSP-HC
PEREIRA, Rosa Maria Rodrigues FMUSP-HC
TERRERI, Maria Teresa
MAGALHAES, Claudia Saad
FERREIRA, Juliana C. O. A. FMUSP-HC
SILVA, Marco Felipe Castro
FERRIANI, Mariana
SAKAMOTO, Ana Paula
FERRIANI, Virginia Paes Leme
CENTEVILLE, Maraisa
SATO, Juliana
SANTOS, Maria Carolina
BONFA, Eloisa FMUSP-HC
SILVA, Clovis Artur FMUSP-HC
dc.date.issued 2019
dc.identifier.citation ADVANCES IN RHEUMATOLOGY, v.59, article ID 3, 5p, 2019
dc.identifier.issn 2523-3106
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/30801
dc.description.abstract Objective: To evaluate prevalence, clinical manifestations, laboratory abnormalities, treatment and outcome in a multicenter cohort of childhood-onset systemic lupus erythematosus (cSLE) patients with and without panniculitis. Methods: Panniculitis was diagnosed due to painful subcutaneous nodules and/or plaques in deep dermis/subcutaneous tissues and lobular/mixed panniculitis with lymphocytic lobular inflammatory infiltrate in skin biopsy. Statistical analysis was performed using Bonferroni correction(p <0.004). Results: Panniculitis was observed in 6/847(0.7%) cSLE. Painful subcutaneous erythematosus and indurated nodules were observed in 6/6 panniculitis patients and painful subcutaneous plaques in 4/6. Generalized distribution was evidenced in 3/ 6 and localized in upper limbs in 2/6 and face in 1/6. Cutaneous hyperpigmentation and/or cutaneous atrophy occurred in 5/6. Histopathology features showed lobular panniculitis without vasculitis in 5/6(one of them had concomitant obliterative vasculopathy due to antiphospholipid syndrome) and panniculitis with vasculitis in 1/6. Comparison between cSLE with panniculitis and 60 cSLE without panniculitis with same disease duration [2.75(0-11.4) vs. 2.83(0-11.8) years,p = 0297], showed higher frequencies of constitutional involvement (67% vs. 1 0%,p = 0.003) and leukopenia (67% vs. 7%p = 0.002). Cutaneous atrophy and hyperpigmentation occurred in 83% of patients. Conclusions: Panniculitis is a rare skin manifestation of cSLE occurring in the first three years of disease with considerable sequelae. The majority of patients have concomitant mild lupus manifestations.
dc.description.sponsorship · Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [301805/2013-0, 303752/2015-7, 301479/2015-1, 305068/2014-8, 303422/2015-7]
· Federico Foundation
· Nucleo de Apoio a Pesquisa ""Saude da Crianca e do Adolescente"" da USP (NAP-CriAd)
dc.language.iso eng
dc.publisher BMC
dc.relation.ispartof Advances in Rheumatology
dc.rights restrictedAccess
dc.subject Lupus erythematosus panniculits; Childhood; Systemic lupus erythematosus and multicenter study
dc.subject.other antiphospholipid syndrome; profundus; diagnosis; manifestations; rheumatology; management; deficiency; criteria; children; patient
dc.title Panniculitis in childhood-onset systemic lupus erythematosus: a multicentric cohort study
dc.type article
dc.rights.holder Copyright BMC
dc.description.group LIM/17
dc.description.group LIM/36
dc.description.group LIM/50
dc.identifier.doi 10.1186/s42358-019-0049-9
dc.identifier.pmid 30658703
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author VERDIER, Monica:FM:
hcfmusp.author ANUARDO, Pedro:FM:
hcfmusp.author GORMEZANO, Natali Weniger Spelling:FM:
hcfmusp.author ROMITI, Ricardo:HC:ICHC
hcfmusp.author CAMPOS, Lucia Maria Arruda:HC:ICR
hcfmusp.author AIKAWA, Nadia Emi:HC:ICHC
hcfmusp.author PEREIRA, Rosa Maria Rodrigues:FM:MCM
hcfmusp.author FERREIRA, Juliana C. O. A.:HC:ICR
hcfmusp.author BONFA, Eloisa:FM:MCM
hcfmusp.author SILVA, Clovis Artur:FM:MPE
hcfmusp.author.external · TERRERI, Maria Teresa:Univ Fed Sao Paulo, Pediat Rheumatol Unit, Sao Paulo, Brazil
· MAGALHAES, Claudia Saad:Sao Paulo State Univ UNESP, Fac Med Botucatu, Botucatu, SP, Brazil
· SILVA, Marco Felipe Castro:Univ Sao Paulo, Childrens Inst, Hosp Clin HCFMUSP, Pediat Rheumatol Unit,Fac Med, Sao Paulo, SP, Brazil
· FERRIANI, Mariana:Univ Sao Paulo, Childrens Inst, Hosp Clin HCFMUSP, Pediat Rheumatol Unit,Fac Med, Sao Paulo, SP, Brazil
· SAKAMOTO, Ana Paula:Univ Fed Sao Paulo, Pediat Rheumatol Unit, Sao Paulo, Brazil
· FERRIANI, Virginia Paes Leme:Univ Sao Paulo, Pediat Rheumatol Unit, Ribeirao Preto Med Sch, Ribeirao Preto, Brazil
· CENTEVILLE, Maraisa:Sao Paulo State Univ Campinas UNICAMP, Campinas, SP, Brazil
· SATO, Juliana:Sao Paulo State Univ UNESP, Fac Med Botucatu, Botucatu, SP, Brazil
· SANTOS, Maria Carolina:Irmandade Santa Casa Misericordia Sao Paulo, Sao Paulo, Brazil
hcfmusp.origem.id WOS:000457520700001
hcfmusp.origem.id 2-s2.0-85060161443
hcfmusp.origem.id SCIELO:S2523-31062019000100201
hcfmusp.publisher.city LONDON
hcfmusp.publisher.country ENGLAND
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dc.description.index MEDLINE
hcfmusp.citation.scopus 0
hcfmusp.citation.wos 0
hcfmusp.affiliation.country Brasil


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