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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLOPES, Maria-Cecilia
dc.contributor.authorSPRUYT, Karen
dc.contributor.authorAZEVEDO-SOSTER, Leticia
dc.contributor.authorROSA, Agostinho
dc.contributor.authorGUILLEMINAULT, Christian
dc.identifier.citationFRONTIERS IN NEUROSCIENCE, v.12, article ID 997, 7p, 2019
dc.description.abstractIntroduction: Changes in the autonomic nervous system due to Obstructive Sleep Apnea (OSA) during the life span have been described. Some pediatric studies have shown cardiovascular effects in children who do not fit the criteria for OSA; namely children with mild sleep disordered breathing. Objective: We investigated heart rate variability (HRV) during sleep in children with chronic snoring and flow limitation events during sleep. Methods: Ten children and adolescents with chronic snoring and an apnea hypopnea index < 1, associated to high Respiratory Index, and 10 controls matched for age, gender, and Tanner stage were monitored following one night of habituation in the sleep laboratory. HRV was studied at each sleep stage. The time and frequency domains were calculated for each 5-min period. Results: All patients were chronic heavy snorers. They presented an apnea hypopnea index = 0.8, respiratory disturbance index = 10.2/h with lowest O2 saturation 96.1 +/- 2.4%. The total power of HRV was decreased in all stages (p < 0.05). There was also a decrease in NN50 and pNN50 during all sleep stages compared to healthy controls (p = 0.0003 and p = 0.03, respectively). Conclusion: A reduction in parasympathetic tone was found in the patient group. This may represent an autonomic impairment during sleep in children with mild SDB. A reduction in HRV in children with habitual snoring could be associated with possible increases in cardiovascular risk in adulthood. Significance: The study indicates that children with habitual snoring have important parasympathetic tone changes during sleep.eng
dc.publisherFRONTIERS MEDIA SAeng
dc.relation.ispartofFrontiers in Neuroscience
dc.subjecthabitual snoringeng
dc.subjectParasympatethic toneeng
dc.subject.otherupper airway-resistanceeng
dc.subject.otherprepubertal childreneng
dc.titleReduction in Parasympathetic Tone During Sleep in Children With Habitual Snoringeng
dc.rights.holderCopyright FRONTIERS MEDIA SAeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Karen:Univ Claude Bernard, Lyon Neurosci Res Ctr, Sch Med, Lyon, France, Agostinho:Univ Lisbon, Inst Syst & Robot, Inst Super Tecn, Laseeb Evolutionary Syst & Biomed Eng Lab, Lisbon, Portugal, Christian:Stanford Univ, Med Ctr, Sleep Disorders Clin, Stanford, CA 94305 USA
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LIM/63 - Laboratório de Investigação Médica em Sono

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