Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/31164
Title: Lack of evidence of seronegative infection in an endemic area of Chagas disease
Authors: OLIVEIRA, Lea Campos deLEE, Tzong-HaeFERREIRA, Ariela MotaBIERRENBACH, Ana LuizaSOUZA-BASQUEIRA, Marcela deOLIVEIRA, Claudia Di LorenzoCARDOSO, Clareci SilvaMOREIRA, Carlos Henrique ValenteOIKAWA, Marcio K.RIBEIRO, Antonio Luiz P.BUSCH, Michael P.SABINO, Ester Cerdeira
Citation: REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, v.61, article ID UNSP e11, 5p, 2019
Abstract: The diagnosis of Chagas disease is based on the detection of Trypanosoma cruzi (T. cruzi)-specific antibodies. Nonetheless, there is concern about the sensitivity of current serological assays due to reports of T. cruzi PCR positivity among seronegative individuals. The aim of this study was to evaluate if T. cruzi seronegative infections occur in endemic areas. We recruited 2,157 individuals that were identified as having Chagas disease in a public health system database of an endemic region in Brazil. All participants were interviewed and 2,091 had a sample collected for serological and PCR testing. From these, 149 (7.1%) had negative serological results. PCR was positive in 610 samples (31.4%) of the 1,942 seropositive samples but in none of the 149 samples from seronegative participants. True T. cruzi seronegative infections seem to be rare (95% CI 0-3.7) and should not be a concern for blood supply, which relies on antibody screening.
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Artigos e Materiais de Revistas Científicas - FM/MIP
Departamento de Moléstias Infecciosas e Parasitárias - FM/MIP

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - IMT
Instituto de Medicina Tropical - IMT

Artigos e Materiais de Revistas Científicas - LIM/03
LIM/03 - Laboratório de Medicina Laboratorial

Artigos e Materiais de Revistas Científicas - LIM/46
LIM/46 - Laboratório de Parasitologia Médica


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