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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLEE, Dong Hoon
dc.contributor.authorREZENDE, Leandro Fornias Machado de
dc.contributor.authorHU, Frank B.
dc.contributor.authorJEON, Justin Y.
dc.contributor.authorGIOVANNUCCI, Edward L.
dc.identifier.citationDIABETES-METABOLISM RESEARCH AND REVIEWS, v.35, n.2, article ID e3095, 9p, 2019
dc.description.abstractBackground Positive association between resting heart rate (RHR) and risk of type 2 diabetes (T2D) has been documented in several studies. However, whether RHR is an independent predictor of T2D and its potential interaction with other risk factors of T2D remain unclear. Methods We conducted a prospective cohort study of 31 156 men from the Health Professionals Follow-up Study (1992-2012). Cox proportional hazard model was used to examine the association between RHR and T2D risk. We further examined whether this association is modified by known risk factors. Lastly, we conducted a meta-analysis of prospective cohort studies. Results During 505 380 person-years of follow-up, we identified 2338 incident T2D cases. The multivariable-adjusted hazard ratio (HR) comparing the highest vs lowest categories of RHR was 1.69 (95% confidence interval [CI], 1.43-2.01). Increase in 10 bpm of RHR was associated with 19% increased risk of T2D in the fully adjusted model (HR, 1.19; 95% CI, 1.14-1.24). The HRs of T2D associated with RHR were stronger among those with normal weight or without hypertension (P interaction < 0.001). Moreover, RHR with other known risk factors cumulatively increased T2D risk. A meta-analysis consistently showed a positive association between RHR and T2D risk (the summary relative risk [RR] for highest vs lowest RHR, 1.53; 95% CI, 1.26-1.86, n = 12, the summary RR per 10 bpm increase, 1.17; 95% CI, 1.09-1.26, n = 13). Conclusions High RHR was independently associated with increased risk of T2D. Our findings suggest that RHR, with other known risk factors, could be a useful tool to predict T2D risk.eng
dc.description.sponsorshipNational Institutes of Health [UM1 CA167552, R01 HL35464]
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP) [2014/25614-4, 2016/21390-0]
dc.relation.ispartofDiabetes-Metabolism Research and Reviews
dc.subjectprospective cohorteng
dc.subjectresting heart rateeng
dc.subjectrisk factoreng
dc.subjecttype 2 diabeteseng
dc.subject.othernervous-system functioneng
dc.subject.otherall-cause mortalityeng
dc.titleResting heart rate and risk of type 2 diabetes: A prospective cohort study and meta-analysiseng
dc.rights.holderCopyright WILEYeng
dc.subject.wosEndocrinology & Metabolismeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Dong Hoon:Harvard TH Chan Sch Publ Hlth, Dept Nutr, 665 Huntington Ave,Bldg 2,3rd Floor, Boston, MA 02115 USA, Frank B.:Harvard TH Chan Sch Publ Hlth, Dept Nutr, 665 Huntington Ave,Bldg 2,3rd Floor, Boston, MA 02115 USA; Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA; Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA; Harvard Med Sch, Boston, MA USA, Justin Y.:Yonsei Univ, Dept Sport Ind Studies, Exercise Med & Rehabil Lab, Seoul, South Korea; Yonsei Univ, Coll Med, ICONS, Exercise Med Ctr Diabet & Canc Patients, Seoul, South Korea, Edward L.:Harvard TH Chan Sch Publ Hlth, Dept Nutr, 665 Huntington Ave,Bldg 2,3rd Floor, Boston, MA 02115 USA; Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA; Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA; Harvard Med Sch, Boston, MA USA
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Artigos e Materiais de Revistas Científicas - FM/Outros
Outros departamentos - FM/Outros

Artigos e Materiais de Revistas Científicas - LIM/38
LIM/38 - Laboratório de Epidemiologia e Imunobiologia

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

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