Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/3137
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorDIAS, Danielle Silva-
dc.contributor.authorBERNARDES, Nathalia-
dc.contributor.authorBARBOZA, Catarina-
dc.contributor.authorSANCHES, Iris Callado-
dc.contributor.authorIRIGOYEN, Maria-Claudia-
dc.contributor.authorANGELIS, Katia De-
dc.date.accessioned2013-10-11T21:31:46Z-
dc.date.available2013-10-11T21:31:46Z-
dc.date.issued2012-
dc.identifier.citationFASEB JOURNAL, v.26, article ID 684.18, 1p, 2012-
dc.identifier.issn0892-6638-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/3137-
dc.description.abstractThe objective was to investigate the effects of aging on cardiovascular parameters in females rats submitted to ovarian hormones deprivation. Female Wistar rats were divided into 4 groups (n=8 each group): young adult (2–3 mo, YA), aged (18 mo, AG), young adult ovariectomized (YA-OVX) and aged ovariectomized (AG-OVX). Arterial pressure (AP) and heart rate (HR) signals were directly recorded in conscious rats. The baroreflex sensitivity (BRS) was evaluated by tachycardic (TR) and bradycardic (BR) responses. The ovariectomy, associated or not with aging, induced increase in AP values (YA-OVX: 124±1.35 and AG-OVX: 136±7.06 vs. YA: 112±2.56 mmHg). There was an additional AP increase in AG-OVX in relation to YA-OVX and AG rats (120±2.6 mmHg). The HR was enhanced in AG, YA-OVX, AG-OVX when compared with YA group. The BR and TR were impaired in AG (0.83±0.06 and 1.50±0.28 bpm/mmHg) as compared to YA group (1.27±0.08 and –3.70±0.30 bpm/mmHg). Ovariectomy (YA-OVX: 1.09±0.08 and 2.11±0.21 and AG-OVX: 0.54±0.05 and –0.88±0.33 bpm/mmHg) decreased both BR and TR in relation to YA and AG groups. Furthermore, BRS was additionally reduced in AG-OVX as compared to YA-OVX rats. These results demonstrated that the ovarian hormone deprivation impact on arterial pressure and BRS is aged dependent.-
dc.language.isoeng-
dc.publisherFEDERATION AMER SOC EXP BIOL-
dc.relation.ispartofFaseb Journal-
dc.rightsrestrictedAccess-
dc.titleAging induced additional impairment in cardiovascular control in ovariectomized rats-
dc.typeconferenceObject-
dc.rights.holderCopyright FEDERATION AMER SOC EXP BIOL-
dc.description.conferencedateAPR 21-25, 2012-
dc.description.conferencelocalSan Diego - CA, EUA-
dc.description.conferencenameExperimental Biology Meeting-
dc.subject.wosBiochemistry & Molecular Biology-
dc.subject.wosBiology-
dc.subject.wosCell Biology-
dc.type.categorymeeting abstract-
dc.type.versionpublishedVersion-
hcfmusp.author.externalDIAS, Danielle Silva:Univ Sao Judas Tadeu, Human Movement Lab, Sao Paulo, Brazil; Nove Julho Univ, Translat Physiol Lab, Sao Paulo, Brazil-
hcfmusp.author.externalBERNARDES, Nathalia:Nove Julho Univ, Translat Physiol Lab, Sao Paulo, Brazil-
hcfmusp.author.externalBARBOZA, Catarina:Univ Sao Judas Tadeu, Human Movement Lab, Sao Paulo, Brazil-
hcfmusp.author.externalSANCHES, Iris Callado:Nove Julho Univ, Translat Physiol Lab, Sao Paulo, Brazil-
hcfmusp.author.externalANGELIS, Katia De:Nove Julho Univ, Translat Physiol Lab, Sao Paulo, Brazil-
hcfmusp.description.volume26-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000310711305048-
hcfmusp.publisher.cityBETHESDA-
hcfmusp.publisher.countryUSA-
dc.description.indexMEDLINE-
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Comunicações em Eventos - HC/InCor
Instituto do Coração - HC/InCor

Comunicações em Eventos - LIM/59
LIM/59 - Laboratório de Biologia Celular


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