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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorABAD, Cesar Cavinato Cal-
dc.contributor.authorMOSTARDA, Cristiano Teixeira-
dc.contributor.authorNASCIMENTO, Ademir Manuel-
dc.contributor.authorSANTOS, Mirailton Alves dos-
dc.contributor.authorSOUZA, Leandro Eziquiel-
dc.contributor.authorFIGUEROA, Diego M. T.-
dc.contributor.authorSANTOS, Fernando-
dc.contributor.authorSOUZA, Pamella Ramona Moraes de-
dc.contributor.authorANGELIS, Katia De-
dc.contributor.authorIRIGOYEN, Maria Claudia-
dc.identifier.citationFASEB JOURNAL, v.27, article ID 712.20, 1p, 2013-
dc.description.abstractThis study was designed to verify the effect of an eight week interval training program (IT) in systolic and diastolic functions and physical performance in heart failure mice (C57B16, n=24). The animals were divided in three groups: 1) Intact sedentary (C), 2) infarcted sedentary (MI-s); and 3) infarcted trained (MI-i). At the begining (M1) and at the end of IT (M2), time of maximal running performance (Tvmáx) was quantified. The ejection fraction (EF), shortening fraction (SF) and isovolumetric relaxation time (IVRT) were accessed by echocardiography in M2. At 60 days after coronary artery occlusion the IT was started (4min at 80% Vmáx x 4min at 40% Vmáx during 60min). The results are presented in mean and SEM. Myocardial infarction area was not different between groups in both evaluation time (M1vsM2). The EF and SF in MI-s were lower than C (44±3.7vs58±3.0% and 22±2vs31±2%, respectively; p≤0.05) but similar between MI-i and C (56±5vs58±3% and 25±3vs31±2%, respectively). The IVRT was higher (p≤0.05) in MI-s (25.6±4ms) than C (13±1ms) while similar in MI-i (15±0.8ms) and C. At the M1 both MI-s and MI-i Tvmáx decreased in comparison with C (620±16 and 644±28vs840±17s, respectively). At the M2, Tvmáx delta percent was higher in MI-i than MI-s (64±8vs15±6%, respectively; p≤0.05) and C (0.53±3%). The results suggest that IT improves cardiac function and physical performance in heart failure mice.-
dc.description.sponsorshipNational Counsel of Technological and Scientific Development (CNPq)-
dc.relation.ispartofFaseb Journal-
dc.titleInterval training program improves cardiac function and physical performance in heart failure mice-
dc.rights.holderCopyright FEDERATION AMER SOC EXP BIOL-
dc.description.conferencedateAPR 20-24, 2013-
dc.description.conferencelocalBoston - MA, EUA-
dc.description.conferencenameJoint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)-
dc.subject.wosBiochemistry & Molecular Biology-
dc.subject.wosCell Biology-
dc.type.categorymeeting abstract-
dc.type.versionpublishedVersion-, Ademir Manuel:FMUSP, Inst Heart, InCor, Sao Paulo, Brazil-, Mirailton Alves dos:FMUSP, Inst Heart, InCor, Sao Paulo, Brazil-, Diego M. T.:FMUSP, Inst Heart, InCor, Sao Paulo, Brazil-, Fernando:FMUSP, Inst Heart, InCor, Sao Paulo, Brazil-, Katia De:Nove de Julho Univ, Sao Paulo, Brazil-
Appears in Collections:

Comunicações em Eventos - HC/InCor
Instituto do Coração - HC/InCor

Comunicações em Eventos - LIM/59
LIM/59 - Laboratório de Biologia Celular

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