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Title: Attenuated Heart Rate Recovery is Associated with Sympathetic Hyperactivity in Patients with Metabolic Syndrome and Obstructive Sleep Apnea
Authors: CEPEDA, Felipe XerezTOSCHI-DIAS, EdgarGODOY, Daniel MartinezMAKI-NUNES, CristianeRONDON, Maria Urbana P. B.ALVES, Maria Janieire N. N.BRAGA, Ana Maria F. W.DRAGER, Luciano F.LORENZI-FILHO, GeraldoNEGRAO, Carlos E.TROMBETTA, Ivani C.
Citation: FASEB JOURNAL, v.27, article ID 928.2, 1p, 2013
Abstract: Obstructive sleep apnea (OSA) and metabolic syndrome (MetS) are independently associated with impaired heart rate recovery (HRR) after maximal exercise. We tested the hypotheses that: 1) MetS+OSA would have an additive effect on attenuation of HRR; 2) The sympathetic hyperactivation would be involved on slower HRR. Newly diagnosed MetS (ATP III) patients, sedentary were divided into: MetS+OSA (n=18, 49±2y) and MetS-OSA (n=21, 44±2y). Normal individuals were also studied (C, n=13, 47±2y). OSA was characterized by apnea-hypopnea index (AHI) >15events/h (polysomnography). Muscle sympathetic nerve activity (MSNA, microneurography), heart rate (EKG), low (LF) and high (HF) frequency power bands and sympatho-vagal balance (LF/HF-Spectral analysis) were measured. The HRR was calculated (HRpeak minus HHR at 1st, 2nd, 4th min). MetS+OSA had higher MSNA, LF and LF/HF compared with MetS-OSA and C. MSNA was higher in MetS-OSA than in C. HF power was lower in MetS+OSA compared with MetS-OSA and C. HRR at 1st, 2nd min was lower in MetS+OSA compared with C (P<0.01) and lower at 4th min compared with Met-OSA and C (P<0.01). Further analyses showed an association between MSNA levels and HRR (P<0.01). In conclusion, OSA exacerbates the attenuation of HRR after maximal exercise in patients with MetS. In addition, the attenuation of HRR is associated with sympathetic hyperactivation.
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Comunicações em Eventos - HC/ICHC
Instituto Central - HC/ICHC

Comunicações em Eventos - HC/InCor
Instituto do Coração - HC/InCor

Comunicações em Eventos - LIM/09
LIM/09 - Laboratório de Pneumologia

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