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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | OU, Qiong | |
dc.contributor.author | CHEN, Baixin | |
dc.contributor.author | LOFTIER, Kelly A. | |
dc.contributor.author | LUO, Yuanming | |
dc.contributor.author | ZHANG, Xilong | |
dc.contributor.author | CHEN, Rui | |
dc.contributor.author | WANG, Qian | |
dc.contributor.author | DRAGER, Luciano F. | |
dc.contributor.author | LORENZI, Geraldo | |
dc.contributor.author | HLAVAC, Michael | |
dc.contributor.author | MCARDLE, Nigel | |
dc.contributor.author | MUKHERJEE, Sutapa | |
dc.contributor.author | MEDIANO, Olga | |
dc.contributor.author | BARBE, Ferran | |
dc.contributor.author | ANDERSON, Craig S. | |
dc.contributor.author | MCEVOY, R. Doug | |
dc.contributor.author | WOODMAN, Richard J. | |
dc.date.accessioned | 2019-05-30T13:19:52Z | |
dc.date.available | 2019-05-30T13:19:52Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | CHEST, v.155, n.4, p.720-729, 2019 | |
dc.identifier.issn | 0012-3692 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/31597 | |
dc.description.abstract | BACKGROUND: Although recent evidence suggests that OSA treatment may cause weight gain, the long-term effects of CPAP on weight are not well established. METHODS: This study was a post hoc analysis of the Sleep Apnea Cardiovascular Endpoints (SAVE) study, a multicenter, randomized trial of CPAP plus standard care vs standard care alone in adults with a history of cardiac or cerebrovascular events and moderate to severe OSA. Participants with weight, BMI, and neck and waist circumferences measured at baseline and during follow-up were included. Linear mixed models were used to examine sex-specific temporal differences, and a sensitivity analysis compared high CPAP adherers ($ 4 h per night) with propensity-matched control participants. RESULTS: A total of 2,483 adults (1,248 in the CPAP group and 1,235 in the control group) were included (mean 6.1 +/- 1.5 measures of weight available). After a mean follow-up of 3.78 years, there was no difference in weight change between the CPAP and control groups, for male subjects (mean [95% CI] between-group difference, 0.07 kg [-0.40 to 0.54]; P = .773) or female subjects (mean [95% CI] between-group difference, -0.14 kg [-0.37 to 0.09]; P = .233). Similarly, there were no significant differences in BMI or other anthropometric measures. Although male participants who used CPAP >= 4 h per night gained slightly more weight than matched male control subjects without CPAP (mean difference, 0.38 kg [95% CI, 0.04 to 0.73]; P = .031), there were no between-group differences in other anthropometric variables, nor were there any differences between female high CPAP adherers and matched control subjects. CONCLUSIONS: Long-term CPAP use in patients with comorbid OSA and cardiovascular disease does not result in clinically significant weight change. | eng |
dc.description.sponsorship | National Health and Medical Research Council of Australia [1006501, 1060078] | |
dc.description.sponsorship | Respironics Sleep and Respiratory Research Foundation | |
dc.description.sponsorship | Philips Respironics | |
dc.description.sponsorship | Fisher & Paykel Healthcare | |
dc.description.sponsorship | Australasian Sleep Trials Network [National Health and Medical Research Council] [343020] | |
dc.description.sponsorship | National Natural Science Foundation of China [81870077] | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER SCIENCE BV | eng |
dc.relation.ispartof | Chest | |
dc.rights | restrictedAccess | eng |
dc.subject | CPAP | eng |
dc.subject | long-term | eng |
dc.subject | OSA | eng |
dc.subject | weight | eng |
dc.subject.other | obstructive sleep-apnea | eng |
dc.subject.other | positive airway pressure | eng |
dc.subject.other | energy-expenditure | eng |
dc.subject.other | american-college | eng |
dc.subject.other | association | eng |
dc.subject.other | prevention | eng |
dc.subject.other | management | eng |
dc.subject.other | guideline | eng |
dc.subject.other | obesity | eng |
dc.subject.other | risk | eng |
dc.title | The Effects of Long-term CPAP on Weight Change in Patients With Comorbid OSA and Cardiovascular Disease Data From the SAVE Trial | eng |
dc.type | article | eng |
dc.rights.holder | Copyright ELSEVIER SCIENCE BV | eng |
dc.contributor.groupauthor | SAVE Investigators | |
dc.identifier.doi | 10.1016/j.chest.2018.08.1082 | |
dc.identifier.pmid | 30268694 | |
dc.subject.wos | Critical Care Medicine | eng |
dc.subject.wos | Respiratory System | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | OU, Qiong:Guangdong Gen Hosp, Guangdong Acad Med Sci, Guangdong Geriatr Inst, Resp & Crit Med Dept,Sleep Ctr, Guangzhou, Guangdong, Peoples R China | |
hcfmusp.author.external | CHEN, Baixin:Guangdong Gen Hosp, Guangdong Acad Med Sci, Guangdong Geriatr Inst, Resp & Crit Med Dept,Sleep Ctr, Guangzhou, Guangdong, Peoples R China | |
hcfmusp.author.external | LOFTIER, Kelly A.:Flinders Univ S Australia, Adelaide Inst Sleep Hlth, GPO Box 2100, Adelaide, SA 5001, Australia | |
hcfmusp.author.external | LUO, Yuanming:Guangzhou Med Univ, Affiliated Hosp 1, State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China | |
hcfmusp.author.external | ZHANG, Xilong:Nanjing Med Univ, Affiliated Hosp 1, Nanjing, Jiangsu, Peoples R China | |
hcfmusp.author.external | CHEN, Rui:Soochow Univ, Affiliated Hosp 2, Suzhou, Jiangsu, Peoples R China | |
hcfmusp.author.external | WANG, Qian:Guangdong Gen Hosp, Guangdong Acad Med Sci, Guangdong Geriatr Inst, Resp & Crit Med Dept,Sleep Ctr, Guangzhou, Guangdong, Peoples R China | |
hcfmusp.author.external | HLAVAC, Michael:Christchurch Hosp, Christchurch, New Zealand | |
hcfmusp.author.external | MCARDLE, Nigel:Sir Charles Gairdner Hosp, Dept Pulm Physiol & Sleep Med, West Australian Sleep Disorders Res Inst, Nedlands, WA, Australia | |
hcfmusp.author.external | MUKHERJEE, Sutapa:Flinders Univ S Australia, Adelaide Inst Sleep Hlth, GPO Box 2100, Adelaide, SA 5001, Australia; Sir Charles Gairdner Hosp, Dept Pulm Physiol & Sleep Med, West Australian Sleep Disorders Res Inst, Nedlands, WA, Australia; Southern Adelaide Local Hlth Network, Resp & Sleep Serv, Sleep Hlth Serv, Bedford Pk, SA, Australia | |
hcfmusp.author.external | MEDIANO, Olga:Univ Hosp Guadalajara, Guadalajara, Spain; Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain | |
hcfmusp.author.external | BARBE, Ferran:Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain; Inst Recerca Biomed Lleida, Resp Dept, Lleida, Spain | |
hcfmusp.author.external | ANDERSON, Craig S.:Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia; Royal Prince Alfred Hosp, Sydney Hlth Partners, Neurol Dept, Sydney, NSW, Australia | |
hcfmusp.author.external | MCEVOY, R. Doug:Flinders Univ S Australia, Adelaide Inst Sleep Hlth, GPO Box 2100, Adelaide, SA 5001, Australia; Southern Adelaide Local Hlth Network, Resp & Sleep Serv, Sleep Hlth Serv, Bedford Pk, SA, Australia | |
hcfmusp.author.external | WOODMAN, Richard J.:Flinders Univ S Australia, Coll Med & Publ Hlth, Flinders Ctr Epidemiol & Biostat, Adelaide, SA, Australia | |
hcfmusp.description.beginpage | 720 | |
hcfmusp.description.endpage | 729 | |
hcfmusp.description.issue | 4 | |
hcfmusp.description.volume | 155 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000463345200022 | |
hcfmusp.origem.id | 2-s2.0-85060079339 | |
hcfmusp.publisher.city | AMSTERDAM | eng |
hcfmusp.publisher.country | NETHERLANDS | eng |
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dc.description.index | MEDLINE | eng |
hcfmusp.citation.scopus | 26 | |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
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