Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/3161
Title: Effect of sinoaortic denervation on blood pressure and heart rate of hypertensive and control rats monitored by telemetry
Authors: SANTOS, FernandoMOREIRA, Edson DiasMOSTARDA, Cristiano TeixeiraBARBOSA, MaikonIRIGOYEN, Maria Claudia
Citation: FASEB JOURNAL, v.27, article ID 689.6, 1p, 2013
Abstract: The aim of this study was to evaluate the effects of sinoaortic denervation (SAD) on systolic blood pressure (SBP) and heart rate (HR), and possible changes in circadian cycle. Wistar (C) and spontaneously hypertensive (H) male rats were submitted to SAD and monitored for two weeks by radio transmitter implanted directly into the abdominal aorta. The acute period (48hs) after SAD procedure was characterized by SBP increase in C (39%) and in H (17%). Surprisingly, a decrease in SBP in H (12%) below baseline levels was observed nine hours after the surgery and was maintained during the next 48 hours. In contrast, SBP in C was still 14% above the baseline. C HR was unchanged, while in H it was 29% increased in the first 48 hours. After two weeks there were no significant differences in SBP and HR in C while in H a 14% reduction in SBP was observed in comparison to the baseline. In this group HR remained 3% higher. We noticed that in H group the behavior of SBP and HR did not change through circadian cycle phases. After SAD the behavior of SPB was still unchanged in H group while HR presented an increase of 6% during the active period. However, SBP behavior in the C was different during light/dark periods, both before and after SAD, with an increase in HR in active period before (8%) and after (11%) SAD. These data suggest that SAD is able to reduce SBP of H and to change the behavior of HR in hypertensive and control rats.
Appears in Collections:

Comunicações em Eventos - FM/MCP
Departamento de Cardio-Pneumologia - FM/MCP

Comunicações em Eventos - HC/InCor
Instituto do Coração - HC/InCor

Comunicações em Eventos - LIM/59
LIM/59 - Laboratório de Biologia Celular


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