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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPADILHA, M.
dc.contributor.authorIAUCCI, J. M.
dc.contributor.authorCABRAL, V. P.
dc.contributor.authorDINIZ, E. M. A.
dc.contributor.authorTADDEI, C. R.
dc.contributor.authorI, S. M. Saad
dc.identifier.citationBENEFICIAL MICROBES, v.10, n.2, p.155-163, 2019
dc.description.abstractHuman milk is an important source of microorganisms for infant gut colonisation. Although the maternal antibiotic prophylaxis is an important strategy to prevent maternal/neonatal sepsis, it has to be investigated how it may affect the human milk microbiota, especially the genus Bifidobacterium, which has been associated to health benefits. Here, we investigated the impact of the maternal antibiotic prophylaxis on the human milk Bifidobacterium spp. and total bacteria counts, in the first week (short-term) and first month (medium-term) after delivery. Human milk samples were collected from 55 healthy lactating women recruited from the University Hospital of the University of Sao Paulo at days 7 +/- 3 and 30 +/- 4 after vaginal delivery. Twenty one volunteers had received maternal antibiotic prophylaxis (MAP group) and 34 had not received MAP (no-MAP group) during or after labour. Total DNA was isolated from milk samples, and the bacterial counts were estimated by quantitative PCR (qPCR). We found lower levels of Bdobacterium in the MAP group in the first week after delivery (median = 2.1 vs 2.4 log of equivalent cells/ml of human milk, for MAP and no-MAP groups, respectively; P=0.01), although there were no statistical differences in total bacteria count. However, no differences were found in Bifidobacterium counts between the groups at day 30 +/- 4 (median = 2.5 vs 2.2 log of equivalent cells/ml of human milk, for MAP and no-MAP groups, respectively; P=0.50). Our results suggest that MAP has a significant impact on Bifidobacterium counts in human milk, reducing this population in the first week after delivery. However, throughout the first month after delivery, the Bifidobacterium counts tend to recover, reaching similar counts to those found in no-MAP group at day 30 +/- 4 after delivery.eng
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/26435-3, 2013/07914-8, 2016/07936-0]
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.relation.ispartofBeneficial Microbes
dc.subjectinfant colonisationeng
dc.subject.otherintestinal microbiotaeng
dc.subject.otherhealthy womeneng
dc.titleMaternal antibiotic prophylaxis affects Bifidobacterium spp. counts in the human milk, during the first week after deliveryeng
dc.rights.holderCopyright WAGENINGEN ACADEMIC PUBLISHERSeng
dc.subject.wosNutrition & Dieteticseng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, M.:Univ Sao Paulo, Sch Pharmaceut Sci, Av Prof Lineu Prestes 580, BR-05508000 Sao Paulo, SP, Brazil; Univ Sao Paulo, Food Res Ctr FoRC, R Lago 250, BR-05508000 Sao Paulo, SP, Brazil, J. M.:Univ Sao Paulo, Sch Pharmaceut Sci, Av Prof Lineu Prestes 580, BR-05508000 Sao Paulo, SP, Brazil, V. P.:Univ Sao Paulo, Sch Pharmaceut Sci, Av Prof Lineu Prestes 580, BR-05508000 Sao Paulo, SP, Brazil; Univ Sao Paulo, Sch Publ Hlth, Av Dr Arnaldo 715, BR-03178200 Sao Paulo, SP, Brazil, C. R.:Univ Sao Paulo, Sch Pharmaceut Sci, Av Prof Lineu Prestes 580, BR-05508000 Sao Paulo, SP, Brazil; Univ Sao Paulo, Sch Arts Sci & Humanities, Rua Arlindo Bettio 117, BR-03828000 Sao Paulo, SP, Brazil, S. M. Saad:Univ Sao Paulo, Sch Pharmaceut Sci, Av Prof Lineu Prestes 580, BR-05508000 Sao Paulo, SP, Brazil; Univ Sao Paulo, Food Res Ctr FoRC, R Lago 250, BR-05508000 Sao Paulo, SP, Brazil
hcfmusp.relation.referenceAloisio I, 2014, APPL MICROBIOL BIOT, V98, P6051, DOI 10.1007/s00253-014-5712-9eng
hcfmusp.relation.referenceAmerican College of Obstetricians and Gynecologists, 2011, Obstet Gynecol, V117, P1472, DOI 10.1097/AOG.0b013e3182238c31eng
hcfmusp.relation.referenceApplied Biosystems, 2003, CREAT STAND CURV GENeng
hcfmusp.relation.referenceAzad MB, 2016, BJOG-INT J OBSTET GY, V123, P983, DOI 10.1111/1471-0528.13601eng
hcfmusp.relation.referenceBerardi A, 2013, J PEDIATR-US, V163, P1099, DOI 10.1016/j.jpeds.2013.05.064eng
hcfmusp.relation.referenceBisgaard H, 2011, J ALLERGY CLIN IMMUN, V128, P646, DOI 10.1016/j.jaci.2011.04.060eng
hcfmusp.relation.referenceBoix-Amoros A, 2016, FRONT MICROBIOL, V7, DOI [10.5389/fmicb.7016.00492, 10.3389/fmicb.2016.00492]eng
hcfmusp.relation.referenceBrandt K, 2012, CLINICS, V67, P113, DOI 10.6061/clinics/2012(02)05eng
hcfmusp.relation.referenceCabrera-Rubio R, 2012, AM J CLIN NUTR, V96, P544, DOI 10.3945/ajcn.112.037382eng
hcfmusp.relation.referenceCenters for Disease Control and Prevention (CDC), 2010, PREV PER GROUP B STReng
hcfmusp.relation.referenceCharbonneau MR, 2016, CELL, V164, P859, DOI 10.1016/j.cell.2016.01.024eng
hcfmusp.relation.referenceCollado MC, 2009, LETT APPL MICROBIOL, V48, P523, DOI 10.1111/j.1472-765X.2009.02567.xeng
hcfmusp.relation.referencede Boer R, 2010, J MICROBIOL METH, V80, P209, DOI 10.1016/j.mimet.2009.11.009eng
hcfmusp.relation.referenceDowling A, 2017, ANTIMICROBIAL RES NO, P536eng
hcfmusp.relation.referenceFERNANDEZ H, 1993, EUR J OBSTET GYN R B, V50, P169, DOI 10.1016/0028-2243(93)90197-Keng
hcfmusp.relation.referenceFernandez L, 2013, PHARMACOL RES, V69, P1, DOI 10.1016/j.phrs.2012.09.001eng
hcfmusp.relation.referenceFuret JP, 2009, FEMS MICROBIOL ECOL, V68, P351, DOI 10.1111/j.1574-6941.2009.00671.xeng
hcfmusp.relation.referenceGillings MR, 2015, GENES-BASEL, V6, P841, DOI 10.3390/genes6030841eng
hcfmusp.relation.referenceGomez-Gallego C, 2016, SEMIN FETAL NEONAT M, V21, P400, DOI 10.1016/j.siny.2016.05.003eng
hcfmusp.relation.referenceHarmsen HJM, 2000, J PEDIATR GASTR NUTR, V30, P61, DOI 10.1097/00005176-200001000-00019eng
hcfmusp.relation.referenceJakobsson HE, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009836eng
hcfmusp.relation.referenceJernberg C, 2007, ISME J, V1, P56, DOI 10.1038/ismej.2007.3eng
hcfmusp.relation.referenceJeurink PV, 2013, BENEF MICROBES, V4, P17, DOI 10.3920/BM2012.0040eng
hcfmusp.relation.referenceJost T, 2013, BR J NUTR, V14, P1eng
hcfmusp.relation.referenceLavanda I, 2011, REV NUTR, V24, P333, DOI 10.1590/S1415-52732011000200014eng
hcfmusp.relation.referenceMarques TM, 2010, CURR OPIN BIOTECH, V21, P149, DOI 10.1016/j.copbio.2010.03.020eng
hcfmusp.relation.referenceMartin R, 2007, J APPL MICROBIOL, V103, P2638, DOI 10.1111/j.1365-2672.2007.03497.xeng
hcfmusp.relation.referenceMartin R, 2009, APPL ENVIRON MICROB, V75, P965, DOI 10.1128/AEM.02063-08eng
hcfmusp.relation.referenceMoro G, 2006, ARCH DIS CHILD, V91, P814, DOI 10.1136/adc.2006.098251eng
hcfmusp.relation.referenceMusilova S, 2017, ACTA MICROBIOL IMM H, V64, P415, DOI 10.1556/030.64.2017.029eng
hcfmusp.relation.referenceNogacka A, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0313-3eng
hcfmusp.relation.referencePannaraj PS, 2017, JAMA PEDIATR, V171, P647, DOI 10.1001/jamapediatrics.2017.0378eng
hcfmusp.relation.referencePenders J, 2007, GUT, V56, P661, DOI 10.1136/gut.2006.100164eng
hcfmusp.relation.referenceR Core Team, 2017, R LANG ENV STAT COMPeng
hcfmusp.relation.referenceRiley M, 2006, NUCLEIC ACIDS RES, V34, P1, DOI 10.1093/nar/gkj405eng
hcfmusp.relation.referenceRingel-Kulka T, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0064315eng
hcfmusp.relation.referenceSakwinska O, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0160856eng
hcfmusp.relation.referenceSchell MA, 2002, P NATL ACAD SCI USA, V99, P14422, DOI 10.1073/pnas.212527599eng
hcfmusp.relation.referenceSharma C, 2017, 3 BIOTECH, V7, DOI 10.1007/s13205-017-0682-0eng
hcfmusp.relation.referenceSolis G, 2010, ANAEROBE, V16, P307, DOI 10.1016/j.anaerobe.2010.02.004eng
hcfmusp.relation.referenceSoto A, 2014, J PEDIATR GASTR NUTR, V59, P78, DOI 10.1097/MPG.0000000000000347eng
hcfmusp.relation.referenceTalarico ST, 2017, CLINICS, V72, P154, DOI 10.6061/clinics/2017(03)05eng
hcfmusp.relation.referenceTanaka S, 2009, FEMS IMMUNOL MED MIC, V56, P80, DOI 10.1111/j.1574-695X.2009.00553.xeng
hcfmusp.relation.referenceVangay P, 2015, CELL HOST MICROBE, V17, P553, DOI 10.1016/j.chom.2015.04.006eng
hcfmusp.relation.referenceWhelan K, 2013, P NUTR SOC, V72, P288, DOI 10.1017/S0029665113001262eng
hcfmusp.relation.referenceWilliams JE, 2017, J NUTR, V147, P1739, DOI 10.3945/jn.117.248864eng
hcfmusp.relation.referenceWorld Health Organization, 2015, WHO REC PREV TREATMeng
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