Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/31865
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorHORVAT, Natally
dc.contributor.authorVEERARAGHAVAN, Harini
dc.contributor.authorPELOSSOF, Raphael A.
dc.contributor.authorFERNANDES, Maria Clara
dc.contributor.authorARORA, Arshi
dc.contributor.authorKHAN, Monika
dc.contributor.authorMARCO, Michael
dc.contributor.authorCHENG, Chin-Tung
dc.contributor.authorGONEN, Mithat
dc.contributor.authorPERNICKA, Jennifer S. Golia
dc.contributor.authorGOLLUB, Marc J.
dc.contributor.authorGARCIA-AGUILLAR, Julio
dc.contributor.authorPETKOVSKA, Iva
dc.date.accessioned2019-05-30T13:42:42Z
dc.date.available2019-05-30T13:42:42Z
dc.date.issued2019
dc.identifier.citationEUROPEAN JOURNAL OF RADIOLOGY, v.113, p.174-181, 2019
dc.identifier.issn0720-048X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/31865
dc.description.abstractObjective: To investigate associations between genetic mutations and qualitative as well as quantitative features on MRI in rectal adenocarcinoma at primary staging. Methods: In this retrospective study, patients with rectal adenocarcinoma, genome sequencing, and pretreatment rectal MRI were included. Statistical analysis was performed to evaluate associations between qualitative features obtained from subjective evaluation of rectal MRI and gene mutations as well as between quantitative textural features and gene mutations. For the qualitative evaluation, Fisher's Exact test was used to analyze categorical associations and Wilcoxon Rank Sum test was used for continuous clinical variables. For the quantitative evaluation, we performed manual segmentation of T2-weighted images for radiomics-based quantitative image analysis. Thirty-four texture features consisting of first order intensity histogram-based features (n= 4), second order Haralick textures (n= 5), and Gabor-edge based Haralick textures were computed at two different orientations. Consensus clustering was performed with 34 computed texture features using the K-means algorithm with Euclidean distance between the texture features. The clusters resulting from the algorithm were then used to enumerate the prevalence of gene mutations in those clusters. Results: In 65 patients, 45 genes were mutated in more than 3/65 patients (5%) and were included in the statistical analysis. Regarding qualitative imaging features, on univariate analysis, tumor location was significantly associated with APC (p= 0.032) and RASA1 mutation (p= 0.032); CRM status was significantly associated with ATM mutation (p= 0.021); and lymph node metastasis was significantly associated with BRCA2 (p= 0.046) mutation. However, these associations were not significant after adjusting for multiple comparisons. Regarding quantitative imaging features, Cluster C1 had tumors with higher mean Gabor edge intensity compared with cluster C2 (theta=0 degrees, p= 0.018;theta= 45 degrees, p= 0.047;theta= 90 degrees, p= 0.037; cluster C3 (theta= 0 degrees, p= 0.18;theta= 45 degrees, p= 0.1;theta= 90 degrees, p= 0.052), and cluster C4 (theta= 0 degrees, p= 0.016;theta= 45 degrees, p= 0.033;theta= 90 degrees, p= 0.014) suggesting that the cluster C1 had tumors with more distinct edges or heterogeneous appearance compared with other clusters. Conclusions: Although this preliminary study showed promising associations between quantitative features and genetic mutations, it did not show any correlation between qualitative features and genetic mutations. Further studies with larger sample size are warranted to validate our preliminary data.eng
dc.description.sponsorshipNIH/NCI [P30 CA008748]
dc.description.sponsorshipColorectal Cancer Research Center at Memorial Sloan Kettering Cancer Center [CC50367]
dc.language.isoeng
dc.publisherELSEVIER IRELAND LTDeng
dc.relation.ispartofEuropean Journal of Radiology
dc.rightsrestrictedAccesseng
dc.subjectRectal neoplasmseng
dc.subjectMagnetic resonance imagingeng
dc.subjectGenomicseng
dc.subjectPrecision medicineeng
dc.subject.othercancereng
dc.subject.otherradiomicseng
dc.titleRadiogenomics of rectal adenocarcinoma in the era of precision medicine: A pilot study of associations between qualitative and quantitative MRI imaging features and genetic mutationseng
dc.typearticleeng
dc.rights.holderCopyright ELSEVIER IRELAND LTDeng
dc.identifier.doi10.1016/j.ejrad.2019.02.022
dc.identifier.pmid30927944
dc.subject.wosRadiology, Nuclear Medicine & Medical Imagingeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalVEERARAGHAVAN, Harini:Mem Sloan Kettering Canc Ctr, Dept Med Phys, New York, NY 10065 USA
hcfmusp.author.externalPELOSSOF, Raphael A.:Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10065 USA
hcfmusp.author.externalFERNANDES, Maria Clara:Mem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave,Box 29, New York, NY 10065 USA; Fleury, Dept Radiol, Rio De Janeiro, Brazil
hcfmusp.author.externalARORA, Arshi:Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA
hcfmusp.author.externalKHAN, Monika:Mem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave,Box 29, New York, NY 10065 USA
hcfmusp.author.externalMARCO, Michael:Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10065 USA
hcfmusp.author.externalCHENG, Chin-Tung:Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10065 USA
hcfmusp.author.externalGONEN, Mithat:Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA
hcfmusp.author.externalPERNICKA, Jennifer S. Golia:Mem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave,Box 29, New York, NY 10065 USA
hcfmusp.author.externalGOLLUB, Marc J.:Mem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave,Box 29, New York, NY 10065 USA
hcfmusp.author.externalGARCIA-AGUILLAR, Julio:Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10065 USA
hcfmusp.author.externalPETKOVSKA, Iva:Mem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave,Box 29, New York, NY 10065 USA
hcfmusp.description.beginpage174
hcfmusp.description.endpage181
hcfmusp.description.volume113
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000462586100024
hcfmusp.origem.id2-s2.0-85061803879
hcfmusp.publisher.cityCLAREeng
hcfmusp.publisher.countryIRELANDeng
hcfmusp.relation.referenceAndreyev HJN, 2001, BRIT J CANCER, V85, P692, DOI 10.1054/bjoc.2001.1964eng
hcfmusp.relation.referenceArmaghany Tannaz, 2012, Gastrointest Cancer Res, V5, P19eng
hcfmusp.relation.referenceBeets-Tan RGH, 2018, EUR RADIOL, V28, P2711, DOI 10.1007/s00330-017-5204-2eng
hcfmusp.relation.referenceBrisse HJ, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0185190eng
hcfmusp.relation.referenceCheng DT, 2015, J MOL DIAGN, V17, P251, DOI 10.1016/j.jmoldx.2014.12.006eng
hcfmusp.relation.referenceChow OS, 2016, ANN SURG ONCOL, V23, P2548, DOI 10.1245/s10434-016-5205-4eng
hcfmusp.relation.referenceDAUGMAN JG, 1985, J OPT SOC AM A, V2, P1160, DOI 10.1364/JOSAA.2.001160eng
hcfmusp.relation.referenceGillies RJ, 2016, RADIOLOGY, V278, P563, DOI 10.1148/radiol.2015151169eng
hcfmusp.relation.referenceGrimm LJ, 2016, J MAGN RESON IMAGING, V43, P1269, DOI 10.1002/jmri.25116eng
hcfmusp.relation.referenceHong HS, 2013, YONSEI MED J, V54, P123, DOI 10.3349/ymj.2013.54.1.123eng
hcfmusp.relation.referenceHorvat N., 2018, RADIOLOGYeng
hcfmusp.relation.referenceHorvat N, 2018, RADIOLOGY, V287, P833, DOI 10.1148/radiol.2018172300eng
hcfmusp.relation.referenceIacopetta B, 2003, HUM MUTAT, V21, P271, DOI 10.1002/humu.10175eng
hcfmusp.relation.referenceKaragkounis G, 2017, CLIN COLON RECT SURG, V30, DOI 10.1055/s-0037-1606373eng
hcfmusp.relation.referenceKarlo CA, 2014, RADIOLOGY, V270, P464, DOI 10.1148/radiol.13130663eng
hcfmusp.relation.referenceKinzler KW, 1996, CELL, V87, P159, DOI 10.1016/S0092-8674(00)81333-1eng
hcfmusp.relation.referenceLiu X., 2017, J NEUROONCOLeng
hcfmusp.relation.referenceLubner MG, 2017, RADIOGRAPHICS, V37, P1483, DOI 10.1148/rg.2017170056eng
hcfmusp.relation.referenceMonti S, 2003, MACH LEARN, V52, P91, DOI 10.1023/A:1023949509487eng
hcfmusp.relation.referenceNapel S, 2015, J MED IMAGING, V2, DOI 10.1117/1.JMI.2.4.041001eng
hcfmusp.relation.referenceNougaret S, 2013, RADIOLOGY, V268, P329, DOI 10.1148/radiol.13121361eng
hcfmusp.relation.referencePinker K., 2018, J MAGN RESON IMAGINGeng
hcfmusp.relation.referencePinker K, 2018, J MAGN RESON IMAGING, V47, P604, DOI 10.1002/jmri.25870eng
hcfmusp.relation.referenceRosenstein BS, 2017, SEMIN RADIAT ONCOL, V27, P300, DOI 10.1016/j.semradonc.2017.04.005eng
hcfmusp.relation.referenceSala E, 2017, CLIN RADIOL, V72, P3, DOI 10.1016/j.crad.2016.09.013eng
hcfmusp.relation.referenceUngerback J, 2012, CARCINOGENESIS, V33, P2126, DOI 10.1093/carcin/bgs256eng
hcfmusp.relation.referenceVargas HA, 2017, RADIOLOGY, V285, P482, DOI 10.1148/radiol.2017161870eng
hcfmusp.relation.referenceWoodard GA, 2018, RADIOLOGY, V286, P60, DOI 10.1148/radiol.2017162333eng
hcfmusp.relation.referenceYang L, 2018, EUR RADIOL, V28, P2058, DOI 10.1007/s00330-017-5146-8eng
hcfmusp.relation.referenceZhou M., 2017, RADIOLOGYeng
dc.description.indexMEDLINEeng
dc.identifier.eissn1872-7727
hcfmusp.citation.scopus17-
hcfmusp.scopus.lastupdate2022-06-10-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - HC/ICESP
Instituto do Câncer do Estado de São Paulo - HC/ICESP

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


Files in This Item:
File Description SizeFormat 
art_HORVAT_Radiogenomics_of_rectal_adenocarcinoma_in_the_era_of_2019.PDF
  Restricted Access
publishedVersion (English)3.07 MBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.