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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGIULIANO, Anna R.
dc.contributor.authorSIRAK, Bradley
dc.contributor.authorABRAHAMSEN, Martha
dc.contributor.authorSILVA, Roberto J. C.
dc.contributor.authorBAGGIO, Maria L.
dc.contributor.authorGALAN, Lenice
dc.contributor.authorCINTRA, Ricardo C.
dc.contributor.authorLAZCANO-PONCE, Eduardo
dc.contributor.authorVILLA, Luisa L.
dc.identifier.citationJOURNAL OF INFECTIOUS DISEASES, v.219, n.5, p.703-710, 2019
dc.description.abstractBackground Genital wart (GW) incidence is high among men. The percentage and rate at which subsequent GW events occur are understudied. The purpose of this study was to describe the rate of subsequent GWs, associated human papillomavirus (HPV) types, and time to subsequent GW event among unvaccinated men. Methods The study was nested within a multinational prospective HPV natural history study of men aged 18-70 years in the United States, Mexico, and Brazil, examined every 6 months for a median follow-up of 50.4 months. Subsequent GW events were defined as GWs detected after 16 weeks of the prior event. Results Forty-four percent of men experienced 1 GW following the initial episode. Men with 2 subsequent events were at highest risk of continued GW experiences, with as high as 10 postinitial GW events. The incidence rate of each subsequent GW increased with increasing events (incidence of first subsequent event was 13.1 vs 36.6/1000 person-months for the fourth event). The proportion of GWs among HPV-6 and/or -11-positive patients remained constant across events. Approximately 63%-69% were positive for 1 of the 9-valent HPV vaccine types. Conclusions These data highlight the high burden of GWs among men across the lifespan and the need for vaccination to prevent multiple GW episodes. This is the first report to examine rates of genital wart (GW) recurrence among men. The high observed rate of GW recurrence supports the public health strategy of broadly vaccinating males to prevent multiple GW episodes and HPV transmission.eng
dc.description.sponsorshipNational Cancer Institute at the National Institutes of Health (NCI/NIH) [R01CA098803]
dc.description.sponsorshipInvestigator-Initiated Studies Program of Merck Sharp Dohme [MIISP 54974]
dc.description.sponsorshipNCI/NIH [R01 CA098803]
dc.publisherOXFORD UNIV PRESS INCeng
dc.relation.ispartofJournal of Infectious Diseases
dc.subjectgenital wartseng
dc.subject.otherhuman-papillomavirus infectioneng
dc.titleGenital Wart Recurrence Among Men Residing in Brazil, Mexico, and the United Stateseng
dc.rights.holderCopyright OXFORD UNIV PRESS INCeng
dc.subject.wosInfectious Diseaseseng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Anna R.:H Lee Moffitt Canc Ctr & Res Inst, Ctr Infect Res Canc, Tampa, FL USA, Bradley:H Lee Moffitt Canc Ctr & Res Inst, Ctr Infect Res Canc, Tampa, FL USA, Martha:H Lee Moffitt Canc Ctr & Res Inst, Ctr Infect Res Canc, Tampa, FL USA, Roberto J. C.:Univ Sao Paulo, Ctr Referencia & Treinamento DST AIDS, Programa Estadual DST AIDS, Hosp Clin,Fac Med, Sao Paulo, Brazil, Lenice:Ludwig Inst Canc Res, Sao Paulo, Brazil, Ricardo C.:Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo, Brazil, Eduardo:Inst Nacl Salud Publ, Ctr Invest Salud Poblac, Cuernavaca, Morelos, Mexico, Luisa L.:Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo, Brazil
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Artigos e Materiais de Revistas Científicas - HC/ICESP
Instituto do Câncer do Estado de São Paulo - HC/ICESP

Artigos e Materiais de Revistas Científicas - LIM/24
LIM/24 - Laboratório de Oncologia Experimental

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