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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | MAIA, Manuel Caitano | |
dc.contributor.author | HANSEN, Aaron | |
dc.contributor.author | ALVES, Carolina | |
dc.contributor.author | SALAH, Samer | |
dc.date.accessioned | 2019-05-30T13:42:43Z | |
dc.date.available | 2019-05-30T13:42:43Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, v.135, p.76-84, 2019 | |
dc.identifier.issn | 1040-8428 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/31872 | |
dc.description.abstract | Non-urothelial (NU) histologies represent less than 10% of bladder cancers, with squamous cell carcinoma (SCC) being the most common subtype (approximately 5%). Bladder SCCs are subdivided into Schistosoma-related or non-Schistosoma-related tumors, with the latter being the most frequent subtype in the western world. Typically, these patients have been excluded or under-represented in clinical trials and thus little is known about treatment efficacy in bladder SCC. To address this paucity of data, extrapolation from urothelial carcinoma (UC) trials can be performed but this approach has inherent limitations. In the era of precision medicine, efforts to characterize the genomic and molecular profiles of bladder tumors may yield evidence to support new targets for effective therapies. We reviewed the available data on biomarkers of bladder SCC and provide suggestions on how these may influence therapeutic testing and clinical trials in the future. | eng |
dc.language.iso | eng | |
dc.publisher | ELSEVIER SCIENCE INC | eng |
dc.relation.ispartof | Critical Reviews in Oncology Hematology | |
dc.rights | restrictedAccess | eng |
dc.subject | Biomarkers | eng |
dc.subject | Squamous | eng |
dc.subject | Bladder | eng |
dc.subject | Non-Bilharzial | eng |
dc.subject | Non-Schistosomiasis | eng |
dc.subject.other | metastatic urothelial carcinoma | eng |
dc.subject.other | growth-factor receptor | eng |
dc.subject.other | radical cystectomy | eng |
dc.subject.other | luminal subtypes | eng |
dc.subject.other | randomized-trial | eng |
dc.subject.other | prognostic value | eng |
dc.subject.other | double-blind | eng |
dc.subject.other | single-arm | eng |
dc.subject.other | phase-i | eng |
dc.subject.other | cancer | eng |
dc.title | Biomarkers in Non-Schistosomiasis-related squamous cell carcinoma of the urinary bladder: A review | eng |
dc.type | article | eng |
dc.rights.holder | Copyright ELSEVIER SCIENCE INC | eng |
dc.identifier.doi | 10.1016/j.critrevonc.2019.01.008 | |
dc.identifier.pmid | 30819449 | |
dc.subject.wos | Oncology | eng |
dc.subject.wos | Hematology | eng |
dc.type.category | review | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | MAIA, Manuel Caitano:Ctr Oncol Parana, Med Oncol, Rod BR 277,1437, BR-82305100 Curitiba, Parana, Brazil | |
hcfmusp.author.external | HANSEN, Aaron:Princess Margaret Canc Ctr, Deparment Med Oncol, Toronto, ON, Canada; Univ Toronto, Toronto, ON, Canada | |
hcfmusp.author.external | SALAH, Samer:King Hussein Canc Ctr, Med Oncol Dept, Amman, Jordan | |
hcfmusp.description.beginpage | 76 | |
hcfmusp.description.endpage | 84 | |
hcfmusp.description.volume | 135 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000461262800010 | |
hcfmusp.origem.id | 2-s2.0-85061114948 | |
hcfmusp.publisher.city | NEW YORK | eng |
hcfmusp.publisher.country | USA | eng |
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dc.description.index | MEDLINE | eng |
dc.identifier.eissn | 1879-0461 | |
hcfmusp.citation.scopus | 9 | - |
hcfmusp.scopus.lastupdate | 2024-02-23 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - ODS/03 |
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