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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLIMA, Vladmir C. Cordeiro de
dc.contributor.authorBALDOTTO, Clarissa S.
dc.contributor.authorBARRIOS, Carlos H.
dc.contributor.authorSOBRINHO, Eldsamira M.
dc.contributor.authorZUKIN, Mauro
dc.contributor.authorMATHIAS, Clarissa
dc.contributor.authorZAFFARONI, Facundo
dc.contributor.authorNERY, Rodrigo C.
dc.contributor.authorMADEIRA, Gabriel
dc.contributor.authorV, Alex Amadio
dc.contributor.authorCOELHO, Juliano C.
dc.contributor.authorGEIB, Guilherme
dc.contributor.authorSIMOES, Maria Fernanda
dc.contributor.authorJR, Gilberto Castro
dc.date.accessioned2019-05-30T13:42:44Z
dc.date.available2019-05-30T13:42:44Z
dc.date.issued2018
dc.identifier.citationJOURNAL OF GLOBAL ONCOLOGY, v.4, 2018
dc.identifier.issn2378-9506
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/31879
dc.description.abstractPurpose Of newly diagnosed patients with non-small-cell lung cancer (NSCLC), stage III accounts for 30%. Most patients are treated with concurrent chemoradiation therapy, but the addition of consolidation chemotherapy (CC) is debatable. We examined the effect of CC in Brazilian patients with stage III NSCLC treated in routine clinical practice. Methods We retrospectively collected data for patients from five different Brazilian cancer institutions who had stage III NSCLC and who were treated with chemoradiation therapy followed or not by CC. Eligible patients were age 18 years or older and must have been treated with cisplatin-carboplatin plus etoposide, paclitaxel, or vinorelbine, concurrently with thoracic radiation therapy (RT). Patients treated with surgery or neoadjuvant chemotherapy were excluded. The primary end point was overall survival (OS). Associations between CC and clinical variables and demographics were evaluated by using Pearson's chi(2) test. Survival curves were calculated by using the Kaplan-Meier method and were compared using the log-rank test. Univariable and multivariable analysis used a Cox proportional hazards model. Results We collected data from 165 patients. Median age was 60 years. Most patients were male (69.1%), white (77.9%), current or former smokers (93.3%), and had stage IIIB disease (52.7%). Adenocarcinoma was the most common histology (47.9%). Weight loss of more than 5% was observed in 39.1% and Eastern Cooperative Oncology Group performance status of 2 was observed in 14.6%. The only variable associated with CC was T stage (P = .022). We observed no statistically significant difference in OS between patients treated or not with CC (P = .128). A total delivered RT dose >= 61 Gy was the only variable independently associated with improved survival (P = .012). Conclusion Brazilian patients with locally advanced NSCLC who were treated with standard treatment achieved OS similar to that reported in randomized trials. CC did not improve OS in patients with stage III NSCLC after concurrent chemoradiation therapy. An RT dose of less than 61 Gy had a negative effect on OS. (C) 2018 by American Society of Clinical Oncologyeng
dc.language.isoeng
dc.publisherAMER SOC CLINICAL ONCOLOGYeng
dc.relation.ispartofJournal of Global Oncology
dc.rightsopenAccesseng
dc.subject.otherphase-iiieng
dc.subject.otherradiation-therapyeng
dc.subject.othertnm classificationeng
dc.subject.otherhoosier oncologyeng
dc.subject.otherchest radiationeng
dc.subject.othercisplatineng
dc.subject.othertrialeng
dc.subject.otherradiotherapyeng
dc.subject.otheretoposideeng
dc.subject.othercarboplatineng
dc.titleStage III Non-Small-Cell Lung Cancer Treated With Concurrent Chemoradiation Followed or Not by Consolidation Chemotherapy: A Survival Analysis From a Brazilian Multicentric Cohorteng
dc.typearticleeng
dc.rights.holderCopyright AMER SOC CLINICAL ONCOLOGYeng
dc.identifier.doi10.1200/JGO.17.00214
dc.identifier.pmid30241276
dc.subject.wosOncologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalLIMA, Vladmir C. Cordeiro de:AC Camargo Canc Ctr, Rio De Janeiro, Brazil
hcfmusp.author.externalBALDOTTO, Clarissa S.:Inst Nacl Canc, Rio De Janeiro, Brazil
hcfmusp.author.externalBARRIOS, Carlos H.:Latin Amer Cooporal Oncol Grp, Porto Alegre, RS, Brazil
hcfmusp.author.externalSOBRINHO, Eldsamira M.:Nucleo Oncol Bahia, Salvador, BA, Brazil
hcfmusp.author.externalZUKIN, Mauro:Inst Nacl Canc, Rio De Janeiro, Brazil
hcfmusp.author.externalMATHIAS, Clarissa:Nucleo Oncol Bahia, Salvador, BA, Brazil
hcfmusp.author.externalZAFFARONI, Facundo:Latin Amer Cooporal Oncol Grp, Porto Alegre, RS, Brazil
hcfmusp.author.externalNERY, Rodrigo C.:AC Camargo Canc Ctr, Rio De Janeiro, Brazil
hcfmusp.author.externalMADEIRA, Gabriel:Inst Nacl Canc, Rio De Janeiro, Brazil
hcfmusp.author.externalCOELHO, Juliano C.:Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil
hcfmusp.author.externalGEIB, Guilherme:Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil
hcfmusp.author.externalSIMOES, Maria Fernanda:Nucleo Oncol Bahia, Salvador, BA, Brazil
hcfmusp.description.volume4
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000462343900001
hcfmusp.origem.id2-s2.0-85060562945
hcfmusp.publisher.cityALEXANDRIAeng
hcfmusp.publisher.countryUSAeng
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dc.description.indexMEDLINEeng
hcfmusp.citation.scopus3-
hcfmusp.scopus.lastupdate2022-06-10-
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Artigos e Materiais de Revistas Científicas - HC/ICESP
Instituto do Câncer do Estado de São Paulo - HC/ICESP

Artigos e Materiais de Revistas Científicas - LIM/24
LIM/24 - Laboratório de Oncologia Experimental

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


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