Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPIRES, Geovanna O.
dc.contributor.authorVIEIRA, Itamar O.
dc.contributor.authorHERNANDES, Fabiana R.
dc.contributor.authorTEIXEIRA, Andre L.
dc.contributor.authorOLIVEIRA, Ivone B.
dc.contributor.authorDOMINGUEZ, Wagner V.
dc.contributor.authorREIS, Luciene M. dos
dc.contributor.authorMONTENEGRO, Fabio M.
dc.contributor.authorMOYSES, Rosa M.
dc.contributor.authorCARVALHO, Aluizio B.
dc.contributor.authorJORGETTI, Vanda
dc.identifier.citationBONE, v.121, p.277-283, 2019
dc.description.abstractSecondary hyperparathyroidism is a complication of chronic kidney disease that compromises skeletal integrity. In patients with secondary hyperparathyroidism undergoing parathyroidectomy, parathyroid hormone levels dramatically decrease. The effects of parathyroidectomy on bone tissue are poorly understood, especially regarding the proteins expressed by osteocytes, such as fibroblast growth factor 23, dentin matrix protein 1, matrix extracellular phosphoglycoprotein, sclerostin, receptor activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin, which regulate bone turnover. The objective of this study was to characterize the bone expression of these proteins by immunohistochemistry and correlate these results with those of bone histomor-phometry before and after parathyroidectomy. We studied bone biopsies that were obtained from 23 patients before and 12 months after parathyroidectomy. We observed an improvement in bone microarchitecture, but impaired mineralization after parathyroidectomy. We found significant increases in sclerostin and osteoprotegerin expression and a decrease in the RANKL/osteoprotegerin ratio after parathyroidectomy, suggesting that their expression is regulated by parathormone. These proteins correlated with structural and bone formation parameters. We conclude that after parathyroidectomy, significant changes occur in the bone expression of osteocyte proteins and that these proteins potentially regulate bone remodeling.eng
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo - FAPESP [2015/13126-8]
dc.subjectChronic kidney diseaseeng
dc.subjectSecondary hyperparathyroidismeng
dc.subjectBone histomorphometryeng
dc.subject.othertrabecular boneeng
dc.titleEffects of parathyroidectomy on the biology of bone tissue in patients with chronic kidney disease and secondary hyperparathyroidismeng
dc.rights.holderCopyright ELSEVIER SCIENCE INCeng
dc.subject.wosEndocrinology & Metabolismeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Itamar O.:Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, LIM 16 Lab Fisiopatol Renal, Sao Paulo, SP, Brazil, Fabiana R.:Univ Fed Sao Paulo, Div Nefrol, Sao Paulo, SP, Brazil, Aluizio B.:Univ Fed Sao Paulo, Div Nefrol, Sao Paulo, SP, Brazil
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.relation.referenceBaron R, 2007, ENDOCRINOLOGY, V148, P2635, DOI 10.1210/en.2007-0270eng
hcfmusp.relation.referenceBellido T, 2005, ENDOCRINOLOGY, V146, P4577, DOI 10.1210/en.2005-0239eng
hcfmusp.relation.referenceCejka D, 2011, CLIN J AM SOC NEPHRO, V6, P877, DOI 10.2215/CJN.06550810eng
hcfmusp.relation.referenceCHARHON SA, 1985, KIDNEY INT, V27, P426, DOI 10.1038/ki.1985.27eng
hcfmusp.relation.referenceDelgado-Calle Jesus, 2015, Curr Mol Biol Rep, V1, P157eng
hcfmusp.relation.referenceDempster DW, 2013, J BONE MINER RES, V28, P1, DOI 10.1002/jbmr.1805eng
hcfmusp.relation.referenceDos Reis LM, 2007, J BONE MINER METAB, V25, P400, DOI 10.1007/s00774-007-0778-4eng
hcfmusp.relation.referenceFeng JQ, 2006, NAT GENET, V38, P1310, DOI 10.1038/ng1905eng
hcfmusp.relation.referenceGomes SA, 2008, J BONE MINER METAB, V26, P110, DOI 10.1007/s00774-007-0788-2eng
hcfmusp.relation.referenceHernandes FR, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0174811eng
hcfmusp.relation.referenceHuang JC, 2004, J BONE MINER RES, V19, P235, DOI 10.1359/JBMR.0301226eng
hcfmusp.relation.referenceJain A, 2004, J CLIN ENDOCR METAB, V89, P4158, DOI 10.1210/jc.2003.032031eng
hcfmusp.relation.referenceKidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group, 2009, Kidney Int Suppl, pS1, DOI 10.1038/ki.2009.188eng
hcfmusp.relation.referenceMa YFL, 2001, ENDOCRINOLOGY, V142, P4047, DOI 10.1210/en.142.9.4047eng
hcfmusp.relation.referenceMELSEN F, 1980, ACTA PATH MICRO IM A, V88, P83eng
hcfmusp.relation.referenceMELSEN F, 1978, CALC TISS RES, V26, P99, DOI 10.1007/BF02013242eng
hcfmusp.relation.referenceMeunier P, 1973, Clin Endocrinol Metab, V2, P239, DOI 10.1016/S0300-595X(73)80042-8eng
hcfmusp.relation.referenceMoe S, 2006, KIDNEY INT, V69, P1945, DOI 10.1038/
hcfmusp.relation.referenceMoe SM, 2011, J BONE MINER RES, V26, P2672, DOI 10.1002/jbmr.485eng
hcfmusp.relation.referenceMurali SK, 2016, PLOS BIOL, V14, DOI 10.1371/journal.pbio.1002427eng
hcfmusp.relation.referencePereira RC, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120856eng
hcfmusp.relation.referencePereira RC, 2009, BONE, V45, P1161, DOI 10.1016/j.bone.2009.08.008eng
hcfmusp.relation.referencePiemonte S, 2012, J ENDOCRINOL INVEST, V35, P866, DOI 10.3275/8522eng
hcfmusp.relation.referencePortillo MR, 2017, REV ENDOCR METAB DIS, V18, P79, DOI 10.1007/s11154-017-9421-4eng
hcfmusp.relation.referenceSapir-Koren R, 2014, BIOFACTORS, V40, P555, DOI 10.1002/biof.1186eng
hcfmusp.relation.referenceStilgren LS, 2004, BONE, V35, P256, DOI 10.1016/j.bone.2004.03.012eng
hcfmusp.relation.referenceWalsh MC, 2014, FRONT IMMUNOL, V5, DOI 10.3389/fimmu.2014.00511eng
hcfmusp.relation.referenceWang L, 2015, J DENT RES, V94, P1408, DOI 10.1177/0022034515599726eng
hcfmusp.relation.referenceYajima A, 2003, AM J KIDNEY DIS, V42, P729, DOI 10.1053/S0272-6386(03)00909-0eng
hcfmusp.relation.referenceYajima A, 2008, KIDNEY INT, V74, P775, DOI 10.1038/ki.2008.242eng
hcfmusp.relation.referenceYajima A, 2010, J BONE MINER RES, V25, P2374, DOI 10.1002/jbmr.126eng
hcfmusp.relation.referenceYamada S, 2017, BONE, V100, P87, DOI 10.1016/j.bone.2016.11.012eng
Appears in Collections:

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/16
LIM/16 - Laboratório de Fisiopatologia Renal

Artigos e Materiais de Revistas Científicas - LIM/28
LIM/28 - Laboratório de Cirurgia Vascular e da Cabeça e Pescoço

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

Files in This Item:
File Description SizeFormat 
  Restricted Access
publishedVersion (English)988.03 kBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.