Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/31909
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPIRES, Geovanna O.
dc.contributor.authorVIEIRA, Itamar O.
dc.contributor.authorHERNANDES, Fabiana R.
dc.contributor.authorTEIXEIRA, Andre L.
dc.contributor.authorOLIVEIRA, Ivone B.
dc.contributor.authorDOMINGUEZ, Wagner V.
dc.contributor.authorREIS, Luciene M. dos
dc.contributor.authorMONTENEGRO, Fabio M.
dc.contributor.authorMOYSES, Rosa M.
dc.contributor.authorCARVALHO, Aluizio B.
dc.contributor.authorJORGETTI, Vanda
dc.date.accessioned2019-05-30T13:45:17Z
dc.date.available2019-05-30T13:45:17Z
dc.date.issued2019
dc.identifier.citationBONE, v.121, p.277-283, 2019
dc.identifier.issn8756-3282
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/31909
dc.description.abstractSecondary hyperparathyroidism is a complication of chronic kidney disease that compromises skeletal integrity. In patients with secondary hyperparathyroidism undergoing parathyroidectomy, parathyroid hormone levels dramatically decrease. The effects of parathyroidectomy on bone tissue are poorly understood, especially regarding the proteins expressed by osteocytes, such as fibroblast growth factor 23, dentin matrix protein 1, matrix extracellular phosphoglycoprotein, sclerostin, receptor activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin, which regulate bone turnover. The objective of this study was to characterize the bone expression of these proteins by immunohistochemistry and correlate these results with those of bone histomor-phometry before and after parathyroidectomy. We studied bone biopsies that were obtained from 23 patients before and 12 months after parathyroidectomy. We observed an improvement in bone microarchitecture, but impaired mineralization after parathyroidectomy. We found significant increases in sclerostin and osteoprotegerin expression and a decrease in the RANKL/osteoprotegerin ratio after parathyroidectomy, suggesting that their expression is regulated by parathormone. These proteins correlated with structural and bone formation parameters. We conclude that after parathyroidectomy, significant changes occur in the bone expression of osteocyte proteins and that these proteins potentially regulate bone remodeling.eng
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo - FAPESP [2015/13126-8]
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INCeng
dc.relation.ispartofBone
dc.rightsrestrictedAccesseng
dc.subjectChronic kidney diseaseeng
dc.subjectSecondary hyperparathyroidismeng
dc.subjectParathyroidectomyeng
dc.subjectBone histomorphometryeng
dc.subjectImmunohistochemistryeng
dc.subjectOsteocyteseng
dc.subject.othertrabecular boneeng
dc.subject.othermineralizationeng
dc.subject.otherosteoprotegerineng
dc.subject.othersclerostineng
dc.subject.otherexpressioneng
dc.subject.otherosteocyteseng
dc.subject.otherhormoneeng
dc.subject.otherrankleng
dc.subject.otherdmp1eng
dc.subject.otherptheng
dc.titleEffects of parathyroidectomy on the biology of bone tissue in patients with chronic kidney disease and secondary hyperparathyroidismeng
dc.typearticleeng
dc.rights.holderCopyright ELSEVIER SCIENCE INCeng
dc.identifier.doi10.1016/j.bone.2019.01.029
dc.identifier.pmid30738215
dc.subject.wosEndocrinology & Metabolismeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalVIEIRA, Itamar O.:Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, LIM 16 Lab Fisiopatol Renal, Sao Paulo, SP, Brazil
hcfmusp.author.externalHERNANDES, Fabiana R.:Univ Fed Sao Paulo, Div Nefrol, Sao Paulo, SP, Brazil
hcfmusp.author.externalCARVALHO, Aluizio B.:Univ Fed Sao Paulo, Div Nefrol, Sao Paulo, SP, Brazil
hcfmusp.description.beginpage277
hcfmusp.description.endpage283
hcfmusp.description.volume121
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000460495000032
hcfmusp.origem.id2-s2.0-85061229550
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUSAeng
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dc.description.indexMEDLINEeng
dc.identifier.eissn1873-2763
hcfmusp.citation.scopus4-
hcfmusp.scopus.lastupdate2022-06-10-
Appears in Collections:

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/16
LIM/16 - Laboratório de Fisiopatologia Renal

Artigos e Materiais de Revistas Científicas - LIM/28
LIM/28 - Laboratório de Cirurgia Vascular e da Cabeça e Pescoço

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


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