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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | FATOBENE, Giancarlo | |
dc.contributor.author | STORER, Barry E. | |
dc.contributor.author | SALIT, Rachel B. | |
dc.contributor.author | LEE, Stephanie J. | |
dc.contributor.author | MARTIN, Paul J. | |
dc.contributor.author | CHENG, Guang-Shing | |
dc.contributor.author | CARPENTER, Paul A. | |
dc.contributor.author | BALGANSUREN, Gansuvd | |
dc.contributor.author | PETERSDORF, Effie W. | |
dc.contributor.author | DELANEY, Colleen | |
dc.contributor.author | SANDMAIER, Brenda M. | |
dc.contributor.author | MILANO, Filippo | |
dc.contributor.author | FLOWERS, Mary E. | |
dc.date.accessioned | 2019-05-30T13:45:17Z | |
dc.date.available | 2019-05-30T13:45:17Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | HAEMATOLOGICA, v.104, n.4, p.835-843, 2019 | |
dc.identifier.issn | 0390-6078 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/31910 | |
dc.description.abstract | We determined the incidence of disability related to chronic graft-versus-host disease (bronchiolitis obliterans, grade >= 2 keratoconjunctivitis sicca, sclerotic features or esophageal stricture) for three categories of alternative donor: cord blood, haplorelated marrow or peripheral blood with post-transplant cyclophosphamide, and unrelated single HLA-allele mismatched peripheral blood. Among 396 consecutive hematopoietic cell transplant recipients, 129 developed chronic graft-versus-host disease with 3-year cumulative incidences of 8% for cord blood, 24% for haplorelated grafts, and 55% for unrelated single HLA-allele mismatched peripheral blood. Disability rates were significantly lower for cord blood [hazard ratio (HR) 0.13; 95% confidence interval (CI): 0.1-0.4] and for the haplorelated group (HR 0.31; 95% CI: 0.1-0.7) compared to the rate in the group transplanted with unrelated single HLA-allele mismatched peripheral blood. Cord blood recipients were also >2-fold more likely to return to work/school within 3 years from the onset of chronic graft-versus-host disease (HR 2.54; 95% CI: 1.1-5.7, P=0.02), and the haplorelated group trended similarly (HR 2.38; 95% CI: 1.0-5.9, P=0.06). Cord blood recipients were more likely to discontinue immunosuppression than were recipients of unrelated single HLA-allele mismatched peripheral blood (HR 3.96; 95% CI: 1.9-8.4, P=0.0003), similarly to the haplorelated group (HR 4.93; 95% CI: 2.2-11.1, P=0.0001). Progression-free survival and non-relapse mortality did not differ between groups grafted from different types of donors. Our observations that, compared to recipients of unrelated single HLA-allele mismatched peripheral blood, recipients of cord blood and haplorelated grafts less often developed disability related to chronic graft-versus-host disease, and were more likely to resume work/school, should help better counseling of pre-hematopoietic cell transplant candidates. | eng |
dc.description.sponsorship | National Institutes of Health, National Cancer Institute [CA018029, CA118953, P30 CA015704] | |
dc.description.sponsorship | National Heart, Lung and Blood Institute [HL122173] | |
dc.description.sponsorship | Division of Hematology and Transfusion Medicine of the University of Sao Paulo, SP, Brazil | |
dc.language.iso | eng | |
dc.publisher | FERRATA STORTI FOUNDATION | eng |
dc.relation.ispartof | Haematologica | |
dc.rights | openAccess | eng |
dc.subject.other | umbilical-cord blood | eng |
dc.subject.other | quality-of-life | eng |
dc.subject.other | bone-marrow-transplantation | eng |
dc.subject.other | acute myeloid-leukemia | eng |
dc.subject.other | term-follow-up | eng |
dc.subject.other | stem-cell | eng |
dc.subject.other | risk-factors | eng |
dc.subject.other | reduced-intensity | eng |
dc.subject.other | myelodysplastic syndrome | eng |
dc.subject.other | societe francaise | eng |
dc.title | Disability related to chronic graft-versus-host disease after alternative donor hematopoietic cell transplantation | eng |
dc.type | article | eng |
dc.rights.holder | Copyright FERRATA STORTI FOUNDATION | eng |
dc.identifier.doi | 10.3324/haematol.2018.202754 | |
dc.identifier.pmid | 30442722 | |
dc.subject.wos | Hematology | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | STORER, Barry E.:Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA | |
hcfmusp.author.external | SALIT, Rachel B.:Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA; Univ Washington, Div Med Oncol, Seattle, WA 98195 USA | |
hcfmusp.author.external | LEE, Stephanie J.:Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA; Univ Washington, Div Med Oncol, Seattle, WA 98195 USA | |
hcfmusp.author.external | MARTIN, Paul J.:Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA; Univ Washington, Div Med Oncol, Seattle, WA 98195 USA | |
hcfmusp.author.external | CHENG, Guang-Shing:Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA; Univ Washington, Div Med Oncol, Seattle, WA 98195 USA | |
hcfmusp.author.external | CARPENTER, Paul A.:Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA; Univ Washington, Div Med Oncol, Seattle, WA 98195 USA | |
hcfmusp.author.external | BALGANSUREN, Gansuvd:Univ Washington, Div Med Oncol, Seattle, WA 98195 USA; Seattle Canc Care Alliance, Seattle, WA USA | |
hcfmusp.author.external | PETERSDORF, Effie W.:Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA; Univ Washington, Div Med Oncol, Seattle, WA 98195 USA | |
hcfmusp.author.external | DELANEY, Colleen:Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA; Univ Washington, Div Med Oncol, Seattle, WA 98195 USA | |
hcfmusp.author.external | SANDMAIER, Brenda M.:Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA; Univ Washington, Div Med Oncol, Seattle, WA 98195 USA | |
hcfmusp.author.external | MILANO, Filippo:Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA; Univ Washington, Div Med Oncol, Seattle, WA 98195 USA | |
hcfmusp.author.external | FLOWERS, Mary E.:Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA; Univ Washington, Div Med Oncol, Seattle, WA 98195 USA | |
hcfmusp.description.beginpage | 835 | |
hcfmusp.description.endpage | 843 | |
hcfmusp.description.issue | 4 | |
hcfmusp.description.volume | 104 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000462841300040 | |
hcfmusp.origem.id | 2-s2.0-85063999231 | |
hcfmusp.publisher.city | PAVIA | eng |
hcfmusp.publisher.country | ITALY | eng |
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dc.description.index | MEDLINE | eng |
hcfmusp.citation.scopus | 20 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICHC |
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