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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLOURENCO, Thais R. de Mattos
dc.contributor.authorPERGIALIOTIS, Vasilis
dc.contributor.authorDUFFY, James M. N.
dc.contributor.authorDURNEA, Constantin
dc.contributor.authorELFITURI, Abdullatif
dc.contributor.authorHADDAD, Jorge M.
dc.contributor.authorBETSCHART, Cornelia
dc.contributor.authorFALCONI, Gabriele
dc.contributor.authorDOUMOUCHTSIS, Stergios K.
dc.identifier.citationNEUROUROLOGY AND URODYNAMICS, v.38, n.2, p.509-524, 2019
dc.description.abstractThe use of synthetic mesh in pelvic organ prolapse surgery is being closely scrutinized because of serious concerns regarding life-changing complications such as erosion, pain, infection, bleeding, dyspareunia, organ perforation, and urinary problems. Randomized trials and their syntheses in meta-analysis offer a unique opportunity to assess efficacy and safety. However, outcomes and outcome measures need to be consistently selected, collected, and reported across randomized trials to be effectively combined in systematic reviews. Aims We evaluated outcome and outcome measure reporting across randomized controlled trials on surgical interventions using synthetic mesh for pelvic organ prolapse. Methods Systematic review of randomized controlled trials using synthetic mesh for the treatment of pelvic organ prolapse. The selected studies were evaluated using Jadad and MOMENT criteria. Outcomes and outcome measures were systematically identified and categorized. Results Seventy-one randomized trials were included. Twenty-four different types of mesh were identified. Included trials reported 110 different outcomes and 60 outcome measures. Erosion (40 trials, 78%), pain (29 trials, 56%), bleeding (31 trials, 61%), and dyspareunia (25 trials, 49%) were the most frequently reported outcomes. The longest follow up was 74 months. Conclusions Most randomized trials evaluating surgical interventions using synthetic mesh for pelvic organ prolapse failed to report on clinically important outcomes and to evaluate efficacy and safety over the medium- and long-term. Developing and implementing a minimum data set, known as a core outcome set, in future vaginal prolapse trials could help address these issues.eng
dc.relation.ispartofNeurourology and Urodynamics
dc.subjectcore outcome setseng
dc.subjectoutcome variationeng
dc.subjectpelvic organ prolapseeng
dc.subjectrandomized controlled trialseng
dc.subjectsynthetic mesheng
dc.subjectsystematic reviewseng
dc.titleA systematic review on reporting outcomes and outcome measures in trials on synthetic mesh procedures for pelvic organ prolapse: Urgent action is needed to improve quality of researcheng
dc.rights.holderCopyright WILEYeng
dc.subject.wosUrology & Nephrologyeng
dc.type.versionpublishedVersioneng, Vasilis:Univ Athens, Sch Med, Lab Expt Surg & Surg Res NS Christeas, Athens, Greece, James M. N.:Univ Oxford, Balliol Coll, Oxford, England; Univ Oxford, Nuffield Dept Primary Care Hlth Sci, Oxford, England, Constantin:Epsom St Helier Univ Hosp NHS Trust, Dept Obstet Gynaecol, London, England, Abdullatif:Epsom St Helier Univ Hosp NHS Trust, Dept Obstet Gynaecol, London, England, Cornelia:Univ Hosp Zurich, Dept Gynecol, Zurich, Switzerland, Gabriele:San Bortolo Hosp, Dept Obstet & Gynaecol, Vicenza, Italy, Stergios K.:Univ Athens, Sch Med, Lab Expt Surg & Surg Res NS Christeas, Athens, Greece; Epsom St Helier Univ Hosp NHS Trust, Dept Obstet Gynaecol, London, England; St Georges Univ London, London, England
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Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HU
Hospital Universitário - HU

Artigos e Materiais de Revistas Científicas - LIM/58
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular

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