Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/31921
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLOURENCO, Thais R. de Mattos
dc.contributor.authorPERGIALIOTIS, Vasilis
dc.contributor.authorDUFFY, James M. N.
dc.contributor.authorDURNEA, Constantin
dc.contributor.authorELFITURI, Abdullatif
dc.contributor.authorHADDAD, Jorge M.
dc.contributor.authorBETSCHART, Cornelia
dc.contributor.authorFALCONI, Gabriele
dc.contributor.authorDOUMOUCHTSIS, Stergios K.
dc.date.accessioned2019-05-30T13:45:19Z
dc.date.available2019-05-30T13:45:19Z
dc.date.issued2019
dc.identifier.citationNEUROUROLOGY AND URODYNAMICS, v.38, n.2, p.509-524, 2019
dc.identifier.issn0733-2467
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/31921
dc.description.abstractThe use of synthetic mesh in pelvic organ prolapse surgery is being closely scrutinized because of serious concerns regarding life-changing complications such as erosion, pain, infection, bleeding, dyspareunia, organ perforation, and urinary problems. Randomized trials and their syntheses in meta-analysis offer a unique opportunity to assess efficacy and safety. However, outcomes and outcome measures need to be consistently selected, collected, and reported across randomized trials to be effectively combined in systematic reviews. Aims We evaluated outcome and outcome measure reporting across randomized controlled trials on surgical interventions using synthetic mesh for pelvic organ prolapse. Methods Systematic review of randomized controlled trials using synthetic mesh for the treatment of pelvic organ prolapse. The selected studies were evaluated using Jadad and MOMENT criteria. Outcomes and outcome measures were systematically identified and categorized. Results Seventy-one randomized trials were included. Twenty-four different types of mesh were identified. Included trials reported 110 different outcomes and 60 outcome measures. Erosion (40 trials, 78%), pain (29 trials, 56%), bleeding (31 trials, 61%), and dyspareunia (25 trials, 49%) were the most frequently reported outcomes. The longest follow up was 74 months. Conclusions Most randomized trials evaluating surgical interventions using synthetic mesh for pelvic organ prolapse failed to report on clinically important outcomes and to evaluate efficacy and safety over the medium- and long-term. Developing and implementing a minimum data set, known as a core outcome set, in future vaginal prolapse trials could help address these issues.eng
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofNeurourology and Urodynamics
dc.rightsrestrictedAccesseng
dc.subjectcore outcome setseng
dc.subjectefficacyeng
dc.subjectoutcome variationeng
dc.subjectpelvic organ prolapseeng
dc.subjectrandomized controlled trialseng
dc.subjectsafetyeng
dc.subjectsynthetic mesheng
dc.subjectsystematic reviewseng
dc.subject.otherseteng
dc.subject.otherprotocoleng
dc.titleA systematic review on reporting outcomes and outcome measures in trials on synthetic mesh procedures for pelvic organ prolapse: Urgent action is needed to improve quality of researcheng
dc.typearticleeng
dc.rights.holderCopyright WILEYeng
dc.identifier.doi10.1002/nau.23871
dc.identifier.pmid30431183
dc.subject.wosUrology & Nephrologyeng
dc.type.categoryrevieweng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalPERGIALIOTIS, Vasilis:Univ Athens, Sch Med, Lab Expt Surg & Surg Res NS Christeas, Athens, Greece
hcfmusp.author.externalDUFFY, James M. N.:Univ Oxford, Balliol Coll, Oxford, England; Univ Oxford, Nuffield Dept Primary Care Hlth Sci, Oxford, England
hcfmusp.author.externalDURNEA, Constantin:Epsom St Helier Univ Hosp NHS Trust, Dept Obstet Gynaecol, London, England
hcfmusp.author.externalELFITURI, Abdullatif:Epsom St Helier Univ Hosp NHS Trust, Dept Obstet Gynaecol, London, England
hcfmusp.author.externalBETSCHART, Cornelia:Univ Hosp Zurich, Dept Gynecol, Zurich, Switzerland
hcfmusp.author.externalFALCONI, Gabriele:San Bortolo Hosp, Dept Obstet & Gynaecol, Vicenza, Italy
hcfmusp.author.externalDOUMOUCHTSIS, Stergios K.:Univ Athens, Sch Med, Lab Expt Surg & Surg Res NS Christeas, Athens, Greece; Epsom St Helier Univ Hosp NHS Trust, Dept Obstet Gynaecol, London, England; St Georges Univ London, London, England
hcfmusp.description.beginpage509
hcfmusp.description.endpage524
hcfmusp.description.issue2
hcfmusp.description.volume38
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000460665400005
hcfmusp.origem.id2-s2.0-85056613058
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
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dc.description.indexMEDLINEeng
dc.identifier.eissn1520-6777
hcfmusp.citation.scopus21
hcfmusp.scopus.lastupdate2022-06-10-
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Artigos e Materiais de Revistas Científicas - HU
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Artigos e Materiais de Revistas Científicas - LIM/58
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular


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