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Title: CD89 Is a Potent Innate Receptor for Bacteria and Mediates Host Protection from Sepsis
Authors: TYMOWSKI, Christian deHEMING, NicholasCORREIA, Mario D. T.ABBAD, LiliaCHAVAROT, NathalieSTANG, Marie-Benedicte LeFLAMENT, HeloiseBEX, JulieBOEDEC, ErwanBOUNAIX, CarineSOLER-TORRONTERAS, RafaelDENAMUR, ErickGALICIER, LionelOKSENHENDLER, EricFEHLING, Hans JoergSILVA, Fabiano Pinheiro daBENHAMOU, MarcMONTEIRO, Renato C.MKADDEM, Sanae Ben
Citation: CELL REPORTS, v.27, n.3, p.762-+, 2019
Abstract: Direct bacterial recognition by innate receptors is crucial for bacterial clearance. Here, we show that the IgA receptor CD89 is a major innate receptor that directly binds bacteria independently of its cognate ligands IgA and c-reactive protein (CRP). This binding is only partially inhibited by serum IgA and induces bacterial phagocytosis by CD11c(+) dendritic cells and monocytes and/or macrophages, suggesting a physiological role in innate host defense. Blood phagocytes from common variable immunodeficiency patients bind, internalize, and kill bacteria in a CD89-dependent manner, confirming the IgA independence of this mechanism. In vivo, CD89 transgenic mice are protected in two different models of sepsis: a model of pneumonia and the cecal ligation and puncture (CLP) polymicrobial model of infection. These data identify CD89 as a first-line innate receptor for bacterial clearance before adaptive responses can be mounted. Fc receptors may emerge as a class of innate receptors for various bacteria with pleiotropic roles.
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Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/51
LIM/51 - Laboratório de Emergências Clínicas

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