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https://observatorio.fm.usp.br/handle/OPI/31934
Title: | CD89 Is a Potent Innate Receptor for Bacteria and Mediates Host Protection from Sepsis |
Authors: | TYMOWSKI, Christian de; HEMING, Nicholas; CORREIA, Mario D. T.; ABBAD, Lilia; CHAVAROT, Nathalie; STANG, Marie-Benedicte Le; FLAMENT, Heloise; BEX, Julie; BOEDEC, Erwan; BOUNAIX, Carine; SOLER-TORRONTERAS, Rafael; DENAMUR, Erick; GALICIER, Lionel; OKSENHENDLER, Eric; FEHLING, Hans Joerg; SILVA, Fabiano Pinheiro da; BENHAMOU, Marc; MONTEIRO, Renato C.; MKADDEM, Sanae Ben |
Citation: | CELL REPORTS, v.27, n.3, p.762-+, 2019 |
Abstract: | Direct bacterial recognition by innate receptors is crucial for bacterial clearance. Here, we show that the IgA receptor CD89 is a major innate receptor that directly binds bacteria independently of its cognate ligands IgA and c-reactive protein (CRP). This binding is only partially inhibited by serum IgA and induces bacterial phagocytosis by CD11c(+) dendritic cells and monocytes and/or macrophages, suggesting a physiological role in innate host defense. Blood phagocytes from common variable immunodeficiency patients bind, internalize, and kill bacteria in a CD89-dependent manner, confirming the IgA independence of this mechanism. In vivo, CD89 transgenic mice are protected in two different models of sepsis: a model of pneumonia and the cecal ligation and puncture (CLP) polymicrobial model of infection. These data identify CD89 as a first-line innate receptor for bacterial clearance before adaptive responses can be mounted. Fc receptors may emerge as a class of innate receptors for various bacteria with pleiotropic roles. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/51 Artigos e Materiais de Revistas Científicas - ODS/03 |
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