Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/31934
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTYMOWSKI, Christian de
dc.contributor.authorHEMING, Nicholas
dc.contributor.authorCORREIA, Mario D. T.
dc.contributor.authorABBAD, Lilia
dc.contributor.authorCHAVAROT, Nathalie
dc.contributor.authorSTANG, Marie-Benedicte Le
dc.contributor.authorFLAMENT, Heloise
dc.contributor.authorBEX, Julie
dc.contributor.authorBOEDEC, Erwan
dc.contributor.authorBOUNAIX, Carine
dc.contributor.authorSOLER-TORRONTERAS, Rafael
dc.contributor.authorDENAMUR, Erick
dc.contributor.authorGALICIER, Lionel
dc.contributor.authorOKSENHENDLER, Eric
dc.contributor.authorFEHLING, Hans Joerg
dc.contributor.authorSILVA, Fabiano Pinheiro da
dc.contributor.authorBENHAMOU, Marc
dc.contributor.authorMONTEIRO, Renato C.
dc.contributor.authorMKADDEM, Sanae Ben
dc.date.accessioned2019-05-30T13:45:22Z
dc.date.available2019-05-30T13:45:22Z
dc.date.issued2019
dc.identifier.citationCELL REPORTS, v.27, n.3, p.762-+, 2019
dc.identifier.issn2211-1247
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/31934
dc.description.abstractDirect bacterial recognition by innate receptors is crucial for bacterial clearance. Here, we show that the IgA receptor CD89 is a major innate receptor that directly binds bacteria independently of its cognate ligands IgA and c-reactive protein (CRP). This binding is only partially inhibited by serum IgA and induces bacterial phagocytosis by CD11c(+) dendritic cells and monocytes and/or macrophages, suggesting a physiological role in innate host defense. Blood phagocytes from common variable immunodeficiency patients bind, internalize, and kill bacteria in a CD89-dependent manner, confirming the IgA independence of this mechanism. In vivo, CD89 transgenic mice are protected in two different models of sepsis: a model of pneumonia and the cecal ligation and puncture (CLP) polymicrobial model of infection. These data identify CD89 as a first-line innate receptor for bacterial clearance before adaptive responses can be mounted. Fc receptors may emerge as a class of innate receptors for various bacteria with pleiotropic roles.eng
dc.description.sponsorshipANR JC [ANR-17-CE17-0002-01]
dc.description.sponsorshipDIM1HEALTH ""action financee par la Region Ile-de-France''
dc.description.sponsorshipLabEx Inflamex [ANR-11-IDEX-0005-02]
dc.description.sponsorshipEquipe Program of the Fondation pour la recherche medicale (FRM)
dc.description.sponsorshipFRM [41482]
dc.language.isoeng
dc.publisherCELL PRESSeng
dc.relation.ispartofCell Reports
dc.rightsrestrictedAccesseng
dc.subject.otherfc-alpha-rieng
dc.subject.otherimmunoglobulin-aeng
dc.subject.othernegative regulationeng
dc.subject.otherinhibitory itamseng
dc.subject.otherigaeng
dc.subject.otheractivationeng
dc.subject.otherexpressioneng
dc.subject.othercellseng
dc.subject.othermicroorganismseng
dc.subject.otheridentificationeng
dc.titleCD89 Is a Potent Innate Receptor for Bacteria and Mediates Host Protection from Sepsiseng
dc.typearticleeng
dc.rights.holderCopyright CELL PRESSeng
dc.identifier.doi10.1016/j.celrep.2019.03.062
dc.identifier.pmid30995475
dc.subject.wosCell Biologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalTYMOWSKI, Christian de:INSERM, U1149, Ctr Rech Inflammat, Paris, France; CNRS, ERL8252, Paris, France; Univ Paris Diderot, Sorbonne Paris Cite, Fac Med, Site Xavier Bichat, Paris, France; Inflamex Lab Excellence, Paris, France
hcfmusp.author.externalHEMING, Nicholas:INSERM, U1149, Ctr Rech Inflammat, Paris, France; CNRS, ERL8252, Paris, France; Univ Paris Diderot, Sorbonne Paris Cite, Fac Med, Site Xavier Bichat, Paris, France; Inflamex Lab Excellence, Paris, France
hcfmusp.author.externalABBAD, Lilia:INSERM, U1149, Ctr Rech Inflammat, Paris, France; CNRS, ERL8252, Paris, France; Univ Paris Diderot, Sorbonne Paris Cite, Fac Med, Site Xavier Bichat, Paris, France; Inflamex Lab Excellence, Paris, France
hcfmusp.author.externalCHAVAROT, Nathalie:INSERM, U1149, Ctr Rech Inflammat, Paris, France; CNRS, ERL8252, Paris, France; Univ Paris Diderot, Sorbonne Paris Cite, Fac Med, Site Xavier Bichat, Paris, France; Inflamex Lab Excellence, Paris, France
hcfmusp.author.externalSTANG, Marie-Benedicte Le:INSERM, U1149, Ctr Rech Inflammat, Paris, France; CNRS, ERL8252, Paris, France; Univ Paris Diderot, Sorbonne Paris Cite, Fac Med, Site Xavier Bichat, Paris, France; Inflamex Lab Excellence, Paris, France
hcfmusp.author.externalFLAMENT, Heloise:INSERM, U1149, Ctr Rech Inflammat, Paris, France; CNRS, ERL8252, Paris, France; Univ Paris Diderot, Sorbonne Paris Cite, Fac Med, Site Xavier Bichat, Paris, France; Inflamex Lab Excellence, Paris, France
hcfmusp.author.externalBEX, Julie:INSERM, U1149, Ctr Rech Inflammat, Paris, France; CNRS, ERL8252, Paris, France; Univ Paris Diderot, Sorbonne Paris Cite, Fac Med, Site Xavier Bichat, Paris, France; Inflamex Lab Excellence, Paris, France
hcfmusp.author.externalBOEDEC, Erwan:INSERM, U1149, Ctr Rech Inflammat, Paris, France; CNRS, ERL8252, Paris, France; Univ Paris Diderot, Sorbonne Paris Cite, Fac Med, Site Xavier Bichat, Paris, France; Inflamex Lab Excellence, Paris, France
hcfmusp.author.externalBOUNAIX, Carine:INSERM, U1149, Ctr Rech Inflammat, Paris, France; CNRS, ERL8252, Paris, France; Univ Paris Diderot, Sorbonne Paris Cite, Fac Med, Site Xavier Bichat, Paris, France; Inflamex Lab Excellence, Paris, France
hcfmusp.author.externalSOLER-TORRONTERAS, Rafael:INSERM, U1149, Ctr Rech Inflammat, Paris, France; CNRS, ERL8252, Paris, France; Univ Paris Diderot, Sorbonne Paris Cite, Fac Med, Site Xavier Bichat, Paris, France; Inflamex Lab Excellence, Paris, France
hcfmusp.author.externalDENAMUR, Erick:Univ Paris Diderot, Sorbonne Paris Cite, Fac Med, Site Xavier Bichat, Paris, France; INSERM, U1137, IAME, Paris, France
hcfmusp.author.externalGALICIER, Lionel:Hop St Louis, AP HP, Dept Clin Immunol, Paris, France; Univ Paris Diderot Paris 7, EA3518, Paris, France
hcfmusp.author.externalOKSENHENDLER, Eric:Hop St Louis, AP HP, Dept Clin Immunol, Paris, France; Univ Paris Diderot Paris 7, EA3518, Paris, France
hcfmusp.author.externalFEHLING, Hans Joerg:Univ Clin Ulm, Inst Immunol, Heidelberg, Germany
hcfmusp.author.externalBENHAMOU, Marc:INSERM, U1149, Ctr Rech Inflammat, Paris, France; CNRS, ERL8252, Paris, France; Univ Paris Diderot, Sorbonne Paris Cite, Fac Med, Site Xavier Bichat, Paris, France; Inflamex Lab Excellence, Paris, France
hcfmusp.author.externalMONTEIRO, Renato C.:INSERM, U1149, Ctr Rech Inflammat, Paris, France; CNRS, ERL8252, Paris, France; Univ Paris Diderot, Sorbonne Paris Cite, Fac Med, Site Xavier Bichat, Paris, France; Inflamex Lab Excellence, Paris, France; Hop Bichat Claude Bernard, Assistance Publ Paris, DHU Fire, Serv Immunol, Paris, France
hcfmusp.author.externalMKADDEM, Sanae Ben:INSERM, U1149, Ctr Rech Inflammat, Paris, France; CNRS, ERL8252, Paris, France; Univ Paris Diderot, Sorbonne Paris Cite, Fac Med, Site Xavier Bichat, Paris, France; Inflamex Lab Excellence, Paris, France
hcfmusp.description.beginpage762
hcfmusp.description.endpage+
hcfmusp.description.issue3
hcfmusp.description.volume27
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000464652000013
hcfmusp.origem.id2-s2.0-85064162445
hcfmusp.publisher.cityCAMBRIDGEeng
hcfmusp.publisher.countryUSAeng
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