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Title: COMT polymorphisms as predictors of cognitive dysfunction during manic and mixed episodes in bipolar I disorder
Citation: BIPOLAR DISORDERS, v.14, suppl.1, Special Issue, p.125-125, 2012
Abstract: Introduction: The dopaminergic system plays an important role in prefrontal cortex (PFC) and is believed to mediate cognitive dysfunction (CD) in Bipolar Disorder (BD). The enzyme catechol- O-methyltransferase (COMT) is involved in the catabolism of dopamine in the PFC, and an association between COMT single nucleotide polymorphisms (snp) and BD has been reported. Also, COMT snp have been associated with executive and working memory performance in healthy subjects, schizophrenics and euthymic BD patients. Materials & Methods: Sixty-two symptomatic, medication-free Bipolar I Disorder patients and 72 healthy controls were evaluated using neuropsychological tests, and genotyped for COMT snp rs4680 and 165599. Results: Patients undergoing mania and mixed episodes carrying allele G of rs4680 or rs165599 had better performance on executive function, memory and intelligence tests. Conclusion: This is the first study that reports a genetic explanation to why cognitive dysfunction varies in BD episodes. Allele G from COMT snp rs4680 and rs165599 may represent reliable state- dependent predictors of global cognitive dysfunction during manic and mixed episodes in Bipolar I Disorder. Further studies in larger samples are necessary to confirm these findings.
Appears in Collections:

Comunicações em Eventos - HC/IPq
Instituto de Psiquiatria - HC/IPq

Comunicações em Eventos - LIM/23
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica

Comunicações em Eventos - LIM/27
LIM/27 - Laboratório de Neurociências

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