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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorEBRAHIMI, Ardalan
dc.contributor.authorGIL, Ziv
dc.contributor.authorAMIT, Moran
dc.contributor.authorYEN, Tzu-Chen
dc.contributor.authorLIAO, Chun-ta
dc.contributor.authorCHATURVEDI, Pankaj
dc.contributor.authorAGARWAL, Jai Prakash
dc.contributor.authorKOWALSKI, Luiz P.
dc.contributor.authorKOHLER, Hugo F.
dc.contributor.authorKREPPEL, Matthias
dc.contributor.authorCERNEA, Claudio R.
dc.contributor.authorBRANDAO, Jason
dc.contributor.authorBACHAR, Gideon
dc.contributor.authorVILLARET, Andrea Bolzoni
dc.contributor.authorFLISS, Dan M.
dc.contributor.authorFRIDMAN, Eran
dc.contributor.authorROBBINS, Kevin Thomas
dc.contributor.authorSHAH, Jatin P.
dc.contributor.authorPATEL, Snehal G.
dc.contributor.authorCLARK, Jonathan R.
dc.identifier.citationHEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, v.41, n.6, p.1935-1942, 2019
dc.description.abstractBackground We aimed to investigate whether depth of invasion (DOI) should be an independent indication for postoperative radiotherapy (PORT) in small oral squamous cell carcinomas (SCC). Methods Retrospective analysis of DOI (<5, 5 to <10, >= 10 mm) and disease-specific survival (DSS) in a multi-institutional international cohort of 1409 patients with oral SCC <= 4 cm in size treated between 1990-2011. Results In patients without other adverse factors (nodal metastases; close [<5 mm] or involved margins), there was no association between DOI and DSS, with an excellent prognosis irrespective of depth. In the absence of PORT, the 5-year disease-specific mortality was 10% with DOI >= 10 mm, 8% with DOI 5-10 mm, and 6% with DOI <5 mm (P = .169), yielding an absolute risk difference of only 4%. Conclusion The deterioration in prognosis with increasing DOI largely reflects an association with other adverse features. In the absence of these, depth alone should not be an indication for PORT outside a clinical trial.eng
dc.description.sponsorshipNCI NIH HHS [P30 CA008748]
dc.relation.ispartofHead and Neck-Journal for the Sciences and Specialties of the Head and Neck
dc.subjectdepth of invasioneng
dc.subjecthead and neck cancereng
dc.subjectlocoregional controleng
dc.subjectoral squamous cell carcinomaeng
dc.subjecttumor thicknesseng
dc.subject.othertumor thicknesseng
dc.subject.otherneck dissectioneng
dc.titleDepth of invasion alone as an indication for postoperative radiotherapy in small oral squamous cell carcinomas: An International Collaborative Studyeng
dc.rights.holderCopyright WILEYeng
dc.contributor.groupauthorIntl Consortium Outcome Res ICOR
dc.description.conferencelocalDarwin, AUSTRALIA
dc.description.conferencenameAnnual Meeting of the Australian-and-New-Zealand-Head-and-Neck-Cancer-Society
dc.type.categoryarticle; proceedings papereng
dc.type.versionpublishedVersioneng, Ardalan:Royal Prince Alfred Hosp, Sydney Head & Neck Canc Inst, Sydney, NSW, Australia; Canberra Hosp, Dept Head & Neck Surg, Canberra, ACT, Australia; Macquarie Univ, Australian Sch Adv Med, Sydney, NSW, Australia; Australian Natl Univ, Sch Med, Coll Hlth & Med, Canberra, ACT, Australia, Ziv:Technion Israel Inst Technol, Lab Appl Canc Res, Haifa, Israel; Technion Israel Inst Technol, Rappaport Sch Med, Rambam Med Ctr, Dept Otolaryngol, Haifa, Israel, Moran:Technion Israel Inst Technol, Lab Appl Canc Res, Haifa, Israel; Technion Israel Inst Technol, Rappaport Sch Med, Rambam Med Ctr, Dept Otolaryngol, Haifa, Israel, Tzu-Chen:Chang Gung Mem Hosp, Dept Nucl Med, Taoyuan, Taiwan; Chang Gung Mem Hosp, Mol Imaging Ctr, Taoyuan, Taiwan, Chun-ta:Chang Gung Mem Hosp, Dept Otorhinolaryngol Head & Neck Surg, Taoyuan, Taiwan, Pankaj:Tata Mem Hosp, Dept Head & Neck Surg, Mumbai, Maharashtra, India, Jai Prakash:Tata Mem Hosp, Dept Radiat Oncol, Mumbai, Maharashtra, India, Luiz P.:Hosp AC Camargo Fund Antonio Prudente, Dept Head & Neck Surg, Sao Paulo, Brazil, Hugo F.:Hosp AC Camargo Fund Antonio Prudente, Dept Head & Neck Surg, Sao Paulo, Brazil, Matthias:Univ Cologne, Dept Oral & Craniomaxillo & Facial Plast Surg, Cologne, Germany, Jason:Univ Sao Paulo, Sch Med, Dept Head & Neck Surg, Sao Paulo, Brazil, Gideon:Rabin Med Ctr, Dept Otolaryngol Head & Neck Surg, Petah Tiqwa, Israel, Andrea Bolzoni:Univ Brescia, Dept ENT, Brescia, Italy, Dan M.:Tel Aviv Med Ctr & Sch Med, Dept Otolaryngol Head & Neck Surg, Tel Aviv, Israel, Eran:Tel Aviv Med Ctr & Sch Med, Dept Otolaryngol Head & Neck Surg, Tel Aviv, Israel, Kevin Thomas:Southern Illinois Univ, Sch Med, Div Otolaryngol Head & Neck Surg, Springfield, IL USA, Jatin P.:Mem Sloan Kettering Canc Ctr, Head & Neck Surg Serv, 1275 York Ave, New York, NY 10021 USA, Snehal G.:Mem Sloan Kettering Canc Ctr, Head & Neck Surg Serv, 1275 York Ave, New York, NY 10021 USA, Jonathan R.:Royal Prince Alfred Hosp, Sydney Head & Neck Canc Inst, Sydney, NSW, Australia; Univ New South Wales, Sch Med, Sydney, NSW, Australia; Univ Sydney, Sch Med, Sydney, NSW, Australia
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Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MCG
Departamento de Cirurgia - FM/MCG

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/28
LIM/28 - Laboratório de Cirurgia Vascular e da Cabeça e Pescoço

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

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