Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/32429
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorDELATORRE, Edson
dc.contributor.authorABREU, Filipe Vieira Santos de
dc.contributor.authorRIBEIRO, Ieda Pereira
dc.contributor.authorGOMEZ, Mariela Martinez
dc.contributor.authorSANTOS, Alexandre Araujo Cunha dos
dc.contributor.authorFERREIRA-DE-BRITO, Anielly
dc.contributor.authorNEVES, Maycon Sebastiao Alberto Santos
dc.contributor.authorBONELLY, Iule
dc.contributor.authorMIRANDA, Rafaella Moraes de
dc.contributor.authorFURTADO, Nathalia Dias
dc.contributor.authorRAPHAEL, Lidiane Menezes Souza
dc.contributor.authorSILVA, Lucileis de Fatima Fernandes da
dc.contributor.authorCASTRO, Marcia Goncalves de
dc.contributor.authorRAMOS, Daniel Garkauskas
dc.contributor.authorROMANO, Alessandro Pecego Martins
dc.contributor.authorKALLAS, Esper Georges
dc.contributor.authorVICENTE, Ana Carolina Paulo
dc.contributor.authorBELLO, Gonzalo
dc.contributor.authorLOURENCO-DE-OLIVEIRA, Ricardo
dc.contributor.authorBONALDO, Myrna Cristina
dc.date.accessioned2019-06-26T17:28:03Z-
dc.date.available2019-06-26T17:28:03Z-
dc.date.issued2019
dc.identifier.citationFRONTIERS IN MICROBIOLOGY, v.10, article ID 1079, 12p, 2019
dc.identifier.issn1664-302X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/32429-
dc.description.abstractThe current outbreak of yellow fever virus (YFV) that is afflicting Brazil since the end of 2016 probably originated from a re-introduction of YFV from endemic areas into the non-endemic Southeastern Brazil. However, the lack of genomic sequences from endemic regions hinders the tracking of YFV's dissemination routes. We assessed the origin and spread of the ongoing YFV Brazilian outbreak analyzing a new set of YFV strains infecting humans, non-human primates (NHPs) and mosquitoes sampled across five Brazilian states from endemic and non-endemic regions between 2015 and 2018. We found two YFV sub-clade 1E lineages circulating in NHP from Goias state (GO), resulting from independent viral introductions into the Araguaia tributary river basin: while one strain from 2017 clustered intermingled with Venezuelan YFV strains from 2000, the other YFV strains sampled in 2015 and 2017 clustered with sequences of the current YFV outbreak in the Brazilian Southeastern region (named YFV2015-2018 lineage), displaying the same molecular signature associated to the current YFV outbreak. After its introduction in GO at around mid-2014, the YFV2015-2018 lineage followed two paths of dissemination outside GO, originating two major YFV sub-lineages: (1) the YFVMG/ES/RJ sub-lineage spread sequentially from the eastern area of Minas Gerais state to Espirito Santo and then to Rio de Janeiro states, following the Southeast Atlantic basin; (2) the YFVMG/SP sub-lineage spread from the southwestern area of Minas Gerais to the metropolitan region of Sao Paulo state, following the Parana basin. These results indicate the ongoing YFV outbreak in Southeastern Brazil originated from a dissemination event from GO almost 2 years before its recognition at the end of 2016. From GO this lineage was introduced in Minas Gerais state at least two times, originating two sub-lineages that followed different routes toward densely populated areas. The spread of YFV outside endemic regions for at least 4 years stresses the imperative importance of the continuous monitoring of YFV to aid decision-making for effective control policies aiming the increase of vaccination coverage to avoid the YFV transmission in densely populated urban centers.eng
dc.description.sponsorshipPrograma Nacional de Pos-Doutorado (PNPD) by the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brazil (CAPES) [001]
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) [001]
dc.description.sponsorshipConselho Nacional Desenvolvimento Cientifico e Tecnologico (CNPq) [309577/2013-6, 312446/2018-7]
dc.description.sponsorshipFundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro [E-26/203.064/2016]
dc.description.sponsorshipInstitut Pasteur, Transversal Research Program (PTR) [528]
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior [COFECUB 799-14, AUXPE 1731/2014]
dc.description.sponsorshipCNPq fellowship for Productivity in Technological Development and Innovative Extension [309471/2016-8]
dc.description.sponsorshipPreventing and Combating the Zika Virus, MCTIC/FNDCT - CNPq/MEC-CAPES/MS-Decit [426767/2018-7, 88881.130684/2016-01]
dc.description.sponsorshipINOVA-Fiocruz [VPPIS-004-FIO18]
dc.language.isoeng
dc.publisherFRONTIERS MEDIA SAeng
dc.relation.ispartofFrontiers in Microbiology
dc.rightsrestrictedAccesseng
dc.subjectyellow fever viruseng
dc.subjectBrazilian outbreakeng
dc.subjectlineageseng
dc.subjectamino acid changeseng
dc.subjectphylogeographyeng
dc.subject.otheryellow-fevereng
dc.subject.otherviruseng
dc.subject.otherevolutionaryeng
dc.subject.otherperformanceeng
dc.titleDistinct YFV Lineages Co-circulated in the Central-Western and Southeastern Brazilian Regions From 2015 to 2018eng
dc.typearticleeng
dc.rights.holderCopyright FRONTIERS MEDIA SAeng
dc.identifier.doi10.3389/fmicb.2019.01079
dc.identifier.pmid31178835
dc.subject.wosMicrobiologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalDELATORRE, Edson:Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Genet Mol Microorganismos, Rio De Janeiro, Brazil
hcfmusp.author.externalABREU, Filipe Vieira Santos de:Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Mosquitos Transmissores Hematozoarios, Rio De Janeiro, Brazil; Inst Fed Norte Minas Gerais, Salinas, Brazil
hcfmusp.author.externalRIBEIRO, Ieda Pereira:Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Biol Mol Flavivirus, Rio De Janeiro, Brazil
hcfmusp.author.externalGOMEZ, Mariela Martinez:Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Biol Mol Flavivirus, Rio De Janeiro, Brazil; Inst Invest Biol Clemente Estable, Div Biol Mol & Genet, Dept Biol & Mol, Montevideo, Uruguay
hcfmusp.author.externalSANTOS, Alexandre Araujo Cunha dos:Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Biol Mol Flavivirus, Rio De Janeiro, Brazil
hcfmusp.author.externalFERREIRA-DE-BRITO, Anielly:Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Mosquitos Transmissores Hematozoarios, Rio De Janeiro, Brazil
hcfmusp.author.externalNEVES, Maycon Sebastiao Alberto Santos:Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Mosquitos Transmissores Hematozoarios, Rio De Janeiro, Brazil
hcfmusp.author.externalBONELLY, Iule:Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Mosquitos Transmissores Hematozoarios, Rio De Janeiro, Brazil
hcfmusp.author.externalMIRANDA, Rafaella Moraes de:Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Mosquitos Transmissores Hematozoarios, Rio De Janeiro, Brazil
hcfmusp.author.externalFURTADO, Nathalia Dias:Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Biol Mol Flavivirus, Rio De Janeiro, Brazil
hcfmusp.author.externalRAPHAEL, Lidiane Menezes Souza:Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Biol Mol Flavivirus, Rio De Janeiro, Brazil
hcfmusp.author.externalSILVA, Lucileis de Fatima Fernandes da:Secretaria Saude Goias, Lab Cent Saude Publ Dr Giovanni Cysneiros, Goiania, Go, Brazil
hcfmusp.author.externalCASTRO, Marcia Goncalves de:Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Mosquitos Transmissores Hematozoarios, Rio De Janeiro, Brazil
hcfmusp.author.externalRAMOS, Daniel Garkauskas:Minist Saude, Coordenacao Geral Vigilancia Doencas Transmissive, Dept Vigilancia Doencas Transmissiveis, Secretaria Vigilancia Saude, Brasilia, DF, Brazil
hcfmusp.author.externalROMANO, Alessandro Pecego Martins:Minist Saude, Coordenacao Geral Vigilancia Doencas Transmissive, Dept Vigilancia Doencas Transmissiveis, Secretaria Vigilancia Saude, Brasilia, DF, Brazil
hcfmusp.author.externalVICENTE, Ana Carolina Paulo:Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Genet Mol Microorganismos, Rio De Janeiro, Brazil
hcfmusp.author.externalBELLO, Gonzalo:Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab AIDS & Imunol Mol, Rio De Janeiro, Brazil
hcfmusp.author.externalLOURENCO-DE-OLIVEIRA, Ricardo:Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Mosquitos Transmissores Hematozoarios, Rio De Janeiro, Brazil
hcfmusp.author.externalBONALDO, Myrna Cristina:Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Biol Mol Flavivirus, Rio De Janeiro, Brazil
hcfmusp.description.articlenumber1079
hcfmusp.description.volume10
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000468911000001
hcfmusp.origem.id2-s2.0-85068711452
hcfmusp.publisher.cityLAUSANNEeng
hcfmusp.publisher.countrySWITZERLANDeng
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dc.description.indexPubMedeng
hcfmusp.citation.scopus19-
hcfmusp.scopus.lastupdate2022-05-06-
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