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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSANTOS, Ubiratan Paula
dc.contributor.authorBRAGA, Alfesio Luis Ferreira
dc.contributor.authorGARCIA, Maria Lucia Bueno
dc.contributor.authorPEREIRA, Luiz Alberto Amador
dc.contributor.authorLIN, Chin An
dc.contributor.authorCHIARELLI, Paulo S.
dc.contributor.authorANDRE, Carmen Diva Saldiva de
dc.contributor.authorANDRE, Paulo Afonso de
dc.contributor.authorSINGER, Julio M.
dc.contributor.authorSALDIVA, Paulo Hilario Nascimento
dc.identifier.citationENVIRONMENTAL RESEARCH, v.174, p.88-94, 2019
dc.description.abstractBackground: Hypertension and air pollution are two important risk factors for cardiovascular morbidity and mortality. Although several studies suggest that air pollution has a significant impact on blood pressure, studies on long-term effects are sparse and still controversial. Objective: To evaluate the effects of exposure of outdoor workers to different levels of traffic-generated PM2.5 on blood pressure. Design: This is an observational panel study. Participants: 88 non-smoking workers exposed to different concentrations of air pollution were evaluated weekly along four successive weeks. Measurements: In each week, personal monitoring of 24-h PM2.5 concentration and 24-h ambulatory blood pressure were measured. The association between blood pressure variables and PM2.5, adjusted for age, body mass index, time in job, daily work hours, diabetes, hypertension and cholesterol was assessed by means of multiple linear regression models fitted by least squares. Results: Exposure to PM2.5 (ranging from 8.5 to 89.7 mu g/m(3)) is significantly and consistently associated with an increase in average blood pressure. An elevation of 10 mu g/m(3) in the concentration of PM2.5 is associated with increments of 3.9 mm Hg (CI 95% = [1.5; 6.3]) in average systolic 24-h blood pressure for hypertensive and/or diabetic workers. Conclusion: Exposure to fine particles, predominantly from vehicular traffic, is associated with elevated blood pressure in hypertensive and/or diabetic workers.eng
dc.description.sponsorshipBrazilian National Council of Technological and Scientific Development (MCTI-CNPq) [18/2006]
dc.description.sponsorshipBrazilian National Council of Technological and Scientific Development (CNPq) [308,613/211-2]
dc.description.sponsorshipCNPq [304,126/2015-2]
dc.relation.ispartofEnvironmental Research
dc.subjectPanel studyeng
dc.subjectAir pollutioneng
dc.subjectBlood pressureeng
dc.subjectVehicular air pollutioneng
dc.subjectPersonal monitoreng
dc.subject.otherlong-term exposureeng
dc.subject.otherambient air-pollutioneng
dc.subject.otherenvironmental stressorseng
dc.subject.othertraffic controllerseng
dc.titleExposure to fine particles increases blood pressure of hypertensive outdoor workers: A panel studyeng
dc.rights.holderCopyright ACADEMIC PRESS INC ELSEVIER SCIENCEeng
dc.subject.wosEnvironmental Scienceseng
dc.subject.wosPublic, Environmental & Occupational Healtheng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Paulo S.:Univ Sao Paulo, Fac Med, Environm Epidemiol Study Grp, Lab Expt Air Pollut,Dept Patol, Ave Dr Arnaldo 455,1 Andar Sala 1304, BR-01246903 Sao Paulo, SP, Brazil, Carmen Diva Saldiva de:Univ Sao Paulo, Inst Matemat & Estat, Rua Matao 1010, BR-05508090 Sao Paulo, SP, Brazil, Julio M.:Univ Sao Paulo, Inst Matemat & Estat, Rua Matao 1010, BR-05508090 Sao Paulo, SP, Brazil
hcfmusp.publisher.citySAN DIEGOeng
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LIM/05 - Laboratório de Poluição Atmosférica Experimental

Artigos e Materiais de Revistas Científicas - LIM/09
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LIM/20 - Laboratório de Terapêutica Experimental

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ODS/03 - Saúde e bem-estar

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ODS/11 - Cidades e comunidades sustentáveis

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