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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | MARRA, Nivea Fazanaro | |
dc.contributor.author | FERNANDES, Maria Teresa Bechere | |
dc.contributor.author | MELO, Maria Edna de | |
dc.contributor.author | CRUZ, Rodrigo Marques da | |
dc.contributor.author | TESS, Beatriz Helena | |
dc.date.accessioned | 2019-08-20T14:46:07Z | - |
dc.date.available | 2019-08-20T14:46:07Z | - |
dc.date.issued | 2019 | |
dc.identifier.citation | ACTA PAEDIATRICA, v.108, n.7, p.1295-1302, 2019 | |
dc.identifier.issn | 0803-5253 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/33139 | - |
dc.description.abstract | Aim We aimed to assess the influence of fasting insulin resistance on metabolically healthy obesity (MHO) prevalence in adolescents and to identify associated factors. Methods This retrospective, registry-based, cross-sectional study included 418 (51.9% girls) 10- to 18-year-old adolescents with obesity from a tertiary outpatient clinic in Sao Paulo, Brazil, between 2009 and 2013. The prevalence of MHO was estimated according to two definitions: (i) no cardiometabolic risk factors (CMRF) by the International Diabetes Federation parameters and (ii) no CMRF and homeostatic model assessment for insulin resistance <3.16. Adjusted prevalence ratios and 95% confidence intervals (CI) evaluated the association of gender, age, pubertal stages, skin colour and degree of obesity with MHO. Results Metabolically healthy obesity prevalence was lower in definition II than definition I (12.7%; 95% CI 9.1-16.3% versus 43.1%; 95% CI 38.0-48.2%, respectively). Adjusted results showed negative association between severe obesity and MHO by both definitions (p <= 0.01). Male and later pubertal stages were also less likely to have MHO, but neither remained significant in definition II. Conclusion Metabolically healthy obesity prevalence decreased when insulin resistance was part of the definition. Detecting pre-clinical insulin resistance may improve the management of treatment-seeking adolescents, especially when they present no CMRF. | eng |
dc.description.sponsorship | Sao Paulo Research Foundation (FAPESP) [2015/23559-9] | |
dc.language.iso | eng | |
dc.publisher | WILEY | eng |
dc.relation.ispartof | Acta Paediatrica | |
dc.rights | restrictedAccess | eng |
dc.subject | Adolescents | eng |
dc.subject | Brazil | eng |
dc.subject | Insulin resistance | eng |
dc.subject | Metabolically healthy obesity | eng |
dc.subject | Prevalence | eng |
dc.subject.other | homeostasis model assessment | eng |
dc.subject.other | children | eng |
dc.subject.other | phenotype | eng |
dc.subject.other | risk | eng |
dc.subject.other | complications | eng |
dc.subject.other | predictors | eng |
dc.subject.other | childhood | eng |
dc.title | Fasting insulin resistance affects the prevalence of metabolically healthy obesity in Brazilian adolescents | eng |
dc.type | article | eng |
dc.rights.holder | Copyright WILEY | eng |
dc.identifier.doi | 10.1111/apa.14684 | |
dc.identifier.pmid | 30536824 | |
dc.subject.wos | Pediatrics | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | CRUZ, Rodrigo Marques da:Univ Sao Paulo, Inst Matemat & Estat, Dept Estat, Sao Paulo, Brazil | |
hcfmusp.description.beginpage | 1295 | |
hcfmusp.description.endpage | 1302 | |
hcfmusp.description.issue | 7 | |
hcfmusp.description.volume | 108 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000471904300019 | |
hcfmusp.origem.id | 2-s2.0-85060557747 | |
hcfmusp.publisher.city | HOBOKEN | eng |
hcfmusp.publisher.country | USA | eng |
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dc.description.index | MEDLINE | eng |
dc.identifier.eissn | 1651-2227 | |
hcfmusp.citation.scopus | 6 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPE Artigos e Materiais de Revistas Científicas - FM/MPR Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/18 Artigos e Materiais de Revistas Científicas - LIM/39 Artigos e Materiais de Revistas Científicas - ODS/03 |
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