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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorRODRIGUEZ, Maria Auxiliadora Choez
dc.contributor.authorMOURA, Diogo Turiani Hourneaux de
dc.contributor.authorRIBEIRO, Igor Braga
dc.contributor.authorBERNARDO, Wanderley Marques
dc.contributor.authorMORITA, Flavio Hiroshi Ananias
dc.contributor.authorMARQUES, Sergio Barbosa
dc.contributor.authorSAKAI, Paulo
dc.contributor.authorMOURA, Eduardo Guimaraes Hourneaux de
dc.date.accessioned2019-09-23T14:18:06Z-
dc.date.available2019-09-23T14:18:06Z-
dc.date.issued2019
dc.identifier.citationENDOSCOPY INTERNATIONAL OPEN, v.7, n.9, p.E1078-E1091, 2019
dc.identifier.issn2364-3722
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/33480-
dc.description.abstractBackground and study aims Endoscopic imaging of Barrett's esophagus (BE) with advanced technologies, such as optical coherence tomography (OCT) and volumetric laser endomicroscopy (VLE), allows targeted biopsies and may reduce the number of random biopsies to detect esophageal neoplasia in the early stages during endoscopic BE surveillance. The aim of this study was to evaluate the accuracy of OCT and VLE in diagnosis of intestinal metaplasia, dysplasia, and high-grade dysplasia (HGD), and intramucosal carcinoma (IMC) in BE. Patients and methods In this systematic review and meta-analysis, the primary outcome measure was diagnostic accuracy of OCT and VLE, in comparison with the gold standard. In the meta-analysis, we calculated sensitivity, specificity, positive likelihood ratio (LR+), negative likelihood ratio (LR-), and diagnostic odds ratio (DOR) for both methods. We performed analyses by patient and by lesion. Results We evaluated 14 studies involving a collective total of 721 patients and 1565 lesions. In the analysis by lesion, VLE showed a pooled sensitivity, specificity, LR+, LR-, DOR, and SROC AUC of 85 %, 73 %, 3.2, 0.21, 15.0, and 0.87, respectively, for detection of HGD/IMC. In the analysis by lesion for detection of HGD/EAC, OCT showed a pooled sensitivity, specificity, LR+, LR-, DOR, and summary receiver operating characteristic area under the curve of 89 %, 91 %, 9.6, 0.12, 81.0, and 0.95, respectively. The accuracy of OCT in identifying intestinal metaplasia showed a pooled sensitivity, specificity, LR+, LR-, and DOR of 92 %, 81 %, 5.06, 0.091, and 55.58, respectively. Conclusion OCT- and VLE-guided targeted biopsies could improve detection of dysplasia and neoplasia. Further studies could determine whether the use of such biopsies might replace the current protocol.eng
dc.language.isoeng
dc.publisherGEORG THIEME VERLAG KGeng
dc.relation.ispartofEndoscopy International Open
dc.rightsopenAccesseng
dc.subject.otherintestinal metaplasiaeng
dc.subject.otherradiofrequency ablationeng
dc.subject.otherdiagnostic performanceeng
dc.subject.othersuspicious findingseng
dc.subject.otherdysplasiaeng
dc.subject.otherfeasibilityeng
dc.subject.otherbiopsyeng
dc.subject.othersurveillanceeng
dc.subject.otherneoplasiaeng
dc.subject.otherfeatureseng
dc.titleVolumetric laser endomicroscopy and optical coherence tomography in Barrett's esophagus: a systematic review and meta-analysiseng
dc.typearticleeng
dc.rights.holderCopyright GEORG THIEME VERLAG KGeng
dc.identifier.doi10.1055/a-0965-6487
dc.identifier.pmid31475224
dc.subject.wosGastroenterology & Hepatologyeng
dc.type.categoryrevieweng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalMOURA, Diogo Turiani Hourneaux de:Harvard Med Sch, Div Gastroenterol Hepatol & Endoscopy, Brigham & Womens Hosp, Boston, MA 02115 USA
hcfmusp.description.beginpageE1078
hcfmusp.description.endpageE1091
hcfmusp.description.issue9
hcfmusp.description.volume7
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000483643600004
hcfmusp.publisher.citySTUTTGARTeng
hcfmusp.publisher.countryGERMANYeng
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dc.identifier.eissn2196-9736
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Artigos e Materiais de Revistas Científicas - FM/MGT
Departamento de Gastroenterologia - FM/MGT

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/35
LIM/35 - Laboratório de Nutrição e Cirurgia Metabólica do Aparelho Digestivo


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