Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPIERROTTI, Ligia Camera
dc.contributor.authorURBANO, Paulo Roberto Palma
dc.contributor.authorNALI, Luiz Henrique da Silva
dc.contributor.authorROMANO, Camila Malta
dc.contributor.authorBICALHO, Camila da Silva
dc.contributor.authorARNONE, Marcelo
dc.contributor.authorVALENTE, Neusa Sakai
dc.contributor.authorPANNUTI, Claudio Sergio
dc.contributor.authorDAVID-NETO, Elias
dc.contributor.authorAZEVEDO, Luiz Sergio
dc.identifier.citationTRANSPLANT INFECTIOUS DISEASE, v.21, n.4, article ID e13133, 9p, 2019
dc.description.abstractTrichodysplasia spinulosa (TS) is a rare disease associated with immunosuppression and induced by a polyomavirus denominated Tricodisplasia Polyomavirus (TSPyV). We report a case of TS 6 months after kidney transplantation in a 65 years-old woman under immunosuppression therapy with prednisone, mycophenolate and tacrolimus. The patient developed follicular papules on the face with a thickening of the skin and alopecia of the eyebrows, leading to distortion of the face and a leonine appearance characteristic of the disease. The skin biopsy confirmed the clinical diagnosis and the presence of TSPyV DNA in the skin was detected. Staining for SV40 was positive. Immunosuppression was changed: mycophenolate was withdrawn, tacrolimus reduced and everolimus added. Intravenous cidofovir and later on leflunomide were added. Although the literature has reported clinical success with topical cidofovir, we were unable to use it because this drug is not available. There was an improvement of skin lesions and on cosmetic appearance. The patient had three rejections (one clinically diagnosed and two other biopsy proven), progressed with renal failure and graft loss. Retrospective analysis of stored urine and blood samples detected TSPyV DNA in some of those samples two months before the TS clinical development. This case highlights the TSPyV detection in blood and urine samples before the development of skin lesions.eng
dc.relation.ispartofTransplant Infectious Disease
dc.subjectkidney transplanteng
dc.subjecttrichodysplasia spinulosaeng
dc.subject.otherviral-associated trichodysplasiaeng
dc.titleViremia and viruria of trichodysplasia spinulosa-associated polyomavirus before the development of clinical disease in a kidney transplant recipienteng
dc.rights.holderCopyright WILEYeng
dc.subject.wosInfectious Diseaseseng
dc.type.categoryoriginal articleeng
hcfmusp.relation.referenceBenoit T, 2010, ARCH DERMATOL, V146, P871, DOI 10.1001/archdermatol.2010.175eng
hcfmusp.relation.referenceBicalho CS, 2018, TRANSPL INFECT DIS, V20, DOI 10.1111/tid.12969eng
hcfmusp.relation.referenceBlake BP, 2011, J DRUGS DERMATOL, V10, P422eng
hcfmusp.relation.referenceBrimhall CL, 2012, ARCH DERMATOL, V148, P863, DOI 10.1001/archdermatol.2012.29eng
hcfmusp.relation.referenceCampbell RM, 2006, ARCH DERMATOL, V142, P1645eng
hcfmusp.relation.referenceChastain MA, 2000, J AM ACAD DERMATOL, V43, P118, DOI 10.1067/mjd.2000.100967eng
hcfmusp.relation.referenceCoogle LP, 2017, PEDIATR TRANSPLANT, V21, DOI 10.1111/petr.12849eng
hcfmusp.relation.referenceDalianis T, 2013, VIROLOGY, V437, P63, DOI 10.1016/j.virol.2012.12.015eng
hcfmusp.relation.referenceDe Gascun CF, 2013, CLIN DEV IMMUNOL, DOI 10.1155/2013/373579eng
hcfmusp.relation.referenceDeCrescenzo Andrew J, 2016, JAAD Case Rep, V2, P307, DOI 10.1016/j.jdcr.2016.07.002eng
hcfmusp.relation.referenceFischer MK, 2012, ARCH DERMATOL, V148, P726, DOI 10.1001/archdermatol.2011.3298eng
hcfmusp.relation.referenceGopalkrishna V, 2000, CLIN MICROBIOL INFEC, V6, P88, DOI 10.1046/j.1469-0691.2000.00024.xeng
hcfmusp.relation.referenceHara S, 2015, NEPHROLOGY, V20, P2, DOI 10.1111/nep.12474eng
hcfmusp.relation.referenceHaycox CL, 1999, J INVEST DERM SYMP P, V4, P268, DOI 10.1038/sj.jidsp.5640227eng
hcfmusp.relation.referenceHeaphy MR, 2004, J AM ACAD DERMATOL, V50, P310, DOI 10.1016/S0190-9622(03)00774-6eng
hcfmusp.relation.referenceHirsch HH, 2014, CLIN MICROBIOL INFEC, V20, P74, DOI 10.1111/1469-0691.12538eng
hcfmusp.relation.referenceHolzer AM, 2009, J AM ACAD DERMATOL, V60, P169, DOI 10.1016/j.jaad.2008.07.051eng
hcfmusp.relation.referenceIZAKOVIC J, 1995, HAUTARZT, V46, P841, DOI 10.1007/s001050050350eng
hcfmusp.relation.referenceJawa P, 2014, KIDNEY INT, V85, P715, DOI 10.1038/ki.2013.268eng
hcfmusp.relation.referenceKassar R, 2017, TRANSPL INFECT DIS, V19, DOI 10.1111/tid.12702eng
hcfmusp.relation.referenceKazem S, 2013, APMIS, V121, P770, DOI 10.1111/apm.12092eng
hcfmusp.relation.referenceKazem S, 2012, J CLIN VIROL, V53, P225, DOI 10.1016/j.jcv.2011.11.007eng
hcfmusp.relation.referenceKirchhof MG, 2014, J CUTAN MED SURG, V18, P430, DOI 10.2310/7750.2014.13189eng
hcfmusp.relation.referenceLaroche A, 2015, J CUTAN MED SURG, V19, P66, DOI 10.2310/7750.2014.13174eng
hcfmusp.relation.referenceLee JSS, 2008, AUSTRALAS J DERMATOL, V49, P57, DOI 10.1111/j.1440-0960.2007.00422.xeng
hcfmusp.relation.referenceLeitenberger Justin J, 2015, JAAD Case Rep, V1, pS33, DOI 10.1016/j.jdcr.2015.09.019eng
hcfmusp.relation.referenceMatthews MR, 2011, J CUTAN PATHOL, V38, P420, DOI 10.1111/j.1600-0560.2010.01664.xeng
hcfmusp.relation.referenceMoktefi A, 2014, AM J DERMATOPATH, V36, pE70, DOI 10.1097/DAD.0b013e318293f620eng
hcfmusp.relation.referenceOsswald SS, 2007, J CUTAN PATHOL, V34, P721, DOI 10.1111/j.1600-0560.2006.00693.xeng
hcfmusp.relation.referenceRosenstein RK, 2017, TRANSPLANTATION, V101, pE314, DOI 10.1097/TP.0000000000001888eng
hcfmusp.relation.referenceSadler GM, 2007, AUSTRALAS J DERMATOL, V48, P110, DOI 10.1111/j.1440-0960.2007.00348.xeng
hcfmusp.relation.referenceSiebrasse EA, 2012, EMERG INFECT DIS, V18, P1676, DOI 10.3201/eid1810.120359eng
hcfmusp.relation.referenceSperling LC, 2004, J AM ACAD DERMATOL, V50, P318, DOI 10.1016/S0190-9622(03)01490-7eng
hcfmusp.relation.referenceUrbano PR, 2016, DIAGN MICR INFEC DIS, V84, P123, DOI 10.1016/j.diagmicrobio.2015.10.011eng
hcfmusp.relation.referenceUrbano PRP, 2014, MICROBIOL RESOUR ANN, V2, DOI 10.1128/genomeA.00694-14eng
hcfmusp.relation.referencevan der Meijden E, 2017, J INFECT DIS, V215, P1080, DOI 10.1093/infdis/jiw403eng
hcfmusp.relation.referencevan der Meijden E, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0081078eng
hcfmusp.relation.referencevan der Meijden E, 2011, EMERG INFECT DIS, V17, P1355, DOI 10.3201/eid1708.110114eng
hcfmusp.relation.referencevan der Meijden E, 2010, PLOS PATHOG, V6, DOI 10.1371/journal.ppat.1001024eng
hcfmusp.relation.referenceWanat KA, 2012, ARCH DERMATOL, V148, P219, DOI 10.1001/archdermatol.2011.1413eng
hcfmusp.relation.referenceWyatt AJ, 2005, AM J SURG PATHOL, V29, P241, DOI 10.1097/01.pas.0000149691.83086.dceng
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MIP
Departamento de Moléstias Infecciosas e Parasitárias - FM/MIP

Artigos e Materiais de Revistas Científicas - HC/ICESP
Instituto do Câncer do Estado de São Paulo - HC/ICESP

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - IMT
Instituto de Medicina Tropical - IMT

Artigos e Materiais de Revistas Científicas - LIM/47
LIM/47 - Laboratório de Hepatologia por Vírus

Artigos e Materiais de Revistas Científicas - LIM/50
LIM/50 - Laboratório de Patologia das Moléstias Infecciosas

Artigos e Materiais de Revistas Científicas - LIM/52
LIM/52 - Laboratório de Virologia

Artigos e Materiais de Revistas Científicas - LIM/53
LIM/53 - Laboratório de Micologia

Files in This Item:
File Description SizeFormat 
  Restricted Access
publishedVersion (English)732.4 kBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.