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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPIERROTTI, Ligia Camera
dc.contributor.authorURBANO, Paulo Roberto Palma
dc.contributor.authorNALI, Luiz Henrique da Silva
dc.contributor.authorROMANO, Camila Malta
dc.contributor.authorBICALHO, Camila da Silva
dc.contributor.authorARNONE, Marcelo
dc.contributor.authorVALENTE, Neusa Sakai
dc.contributor.authorPANNUTI, Claudio Sergio
dc.contributor.authorDAVID-NETO, Elias
dc.contributor.authorAZEVEDO, Luiz Sergio
dc.date.accessioned2019-09-23T14:18:20Z-
dc.date.available2019-09-23T14:18:20Z-
dc.date.issued2019
dc.identifier.citationTRANSPLANT INFECTIOUS DISEASE, v.21, n.4, article ID e13133, 9p, 2019
dc.identifier.issn1398-2273
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/33493-
dc.description.abstractTrichodysplasia spinulosa (TS) is a rare disease associated with immunosuppression and induced by a polyomavirus denominated Tricodisplasia Polyomavirus (TSPyV). We report a case of TS 6 months after kidney transplantation in a 65 years-old woman under immunosuppression therapy with prednisone, mycophenolate and tacrolimus. The patient developed follicular papules on the face with a thickening of the skin and alopecia of the eyebrows, leading to distortion of the face and a leonine appearance characteristic of the disease. The skin biopsy confirmed the clinical diagnosis and the presence of TSPyV DNA in the skin was detected. Staining for SV40 was positive. Immunosuppression was changed: mycophenolate was withdrawn, tacrolimus reduced and everolimus added. Intravenous cidofovir and later on leflunomide were added. Although the literature has reported clinical success with topical cidofovir, we were unable to use it because this drug is not available. There was an improvement of skin lesions and on cosmetic appearance. The patient had three rejections (one clinically diagnosed and two other biopsy proven), progressed with renal failure and graft loss. Retrospective analysis of stored urine and blood samples detected TSPyV DNA in some of those samples two months before the TS clinical development. This case highlights the TSPyV detection in blood and urine samples before the development of skin lesions.eng
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofTransplant Infectious Disease
dc.rightsrestrictedAccesseng
dc.subjectkidney transplanteng
dc.subjectpolyomaviruseng
dc.subjecttrichodysplasia spinulosaeng
dc.subjectviremiaeng
dc.subjectviruriaeng
dc.subject.otherviral-associated trichodysplasiaeng
dc.subject.otherinfectioneng
dc.subject.otherpatienteng
dc.subject.otherimmunosuppressioneng
dc.subject.otherdnaeng
dc.titleViremia and viruria of trichodysplasia spinulosa-associated polyomavirus before the development of clinical disease in a kidney transplant recipienteng
dc.typearticleeng
dc.rights.holderCopyright WILEYeng
dc.identifier.doi10.1111/tid.13133
dc.identifier.pmid31233669
dc.subject.wosImmunologyeng
dc.subject.wosInfectious Diseaseseng
dc.subject.wosTransplantationeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.description.articlenumbere13133
hcfmusp.description.issue4
hcfmusp.description.volume21
hcfmusp.origemWOS
hcfmusp.origem.idWOS:000474262600001
hcfmusp.origem.id2-s2.0-85068613425
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
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dc.description.indexMEDLINEeng
dc.identifier.eissn1399-3062
hcfmusp.citation.scopus5-
hcfmusp.scopus.lastupdate2022-06-10-
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Artigos e Materiais de Revistas Científicas - FM/MIP
Departamento de Moléstias Infecciosas e Parasitárias - FM/MIP

Artigos e Materiais de Revistas Científicas - HC/ICESP
Instituto do Câncer do Estado de São Paulo - HC/ICESP

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - IMT
Instituto de Medicina Tropical - IMT

Artigos e Materiais de Revistas Científicas - LIM/47
LIM/47 - Laboratório de Hepatologia por Vírus

Artigos e Materiais de Revistas Científicas - LIM/50
LIM/50 - Laboratório de Patologia das Moléstias Infecciosas

Artigos e Materiais de Revistas Científicas - LIM/52
LIM/52 - Laboratório de Virologia

Artigos e Materiais de Revistas Científicas - LIM/53
LIM/53 - Laboratório de Micologia


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