Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/33526
Title: Influence of a mannose-binding lectin gene polymorphism and exposure to Chlamydia trachomatis on fallopian tube obstruction in Brazilian woman
Authors: VINAGRE, Joao G.WITKIN, Steven S.RIBEIRO, Sergio C.ROBIAL, RenataI, Eiko FukazawaORTOLANI, Carla C.BARACAT, Edmund C.LINHARES, Iara M.
Citation: ARCHIVES OF GYNECOLOGY AND OBSTETRICS, v.300, n.3, p.641-645, 2019
Abstract: Purpose Factors influencing fallopian tube occlusion in women with a lower genital tract infection remain incompletely elucidated. We evaluated whether a polymorphism in the mannose-binding lectin (MBL) gene at codon 54 influences the occurrence of fallopian tube blockage in relation to exposure to Chlamydia trachomatis. Methods In a case-control study at The Hospital das Clinicas, University of Sao Paulo, Brazil, 75 women with hysterosalpingography-documented tubal occlusion and 75 women with patent fallopian tubes were analyzed for detection of single-nucleotide polymorphism in codon 54 of the MBL gene and for IgG anti-C. trachomatis antibodies in their sera. Both groups were matched for age, race, and sexual variables. Results Prior exposure to C. trachomatis, as evidenced by the presence of IgG antibodies, was comparable in both groups. Detection of the polymorphic MBL allele was more prevalent in women with blocked tubes (p < 0.01), regardless of whether or not there was evidence of prior chlamydial exposure. Conclusion The level of MBL-related innate immunity influences the consequences of infection by C. trachomatis or other microbes.
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MOG
Departamento de Obstetrícia e Ginecologia - FM/MOG

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/58
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular


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