https://observatorio.fm.usp.br/handle/OPI/33551
DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | BULUBAS, Lucia | - |
dc.contributor.author | PADBERG, Frank | - |
dc.contributor.author | Bueno, Priscila V. | - |
dc.contributor.author | DURAN, Fabio | - |
dc.contributor.author | BUSATTO, Geraldo | - |
dc.contributor.author | AMARO JR., Edson | - |
dc.contributor.author | BENSENOR, Isabela M. | - |
dc.contributor.author | LOTUFO, Paulo A. | - |
dc.contributor.author | GOERIGK, Stephan | - |
dc.contributor.author | GATTAZ, Wagner | - |
dc.contributor.author | KEESER, Daniel | - |
dc.contributor.author | BRUNONI, Andre R. | - |
dc.date.accessioned | 2019-09-23T14:20:13Z | - |
dc.date.available | 2019-09-23T14:20:13Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | BRAIN STIMULATION, v.12, n.5, p.1197-1204, 2019 | - |
dc.identifier.issn | 1935-861X | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/33551 | - |
dc.description.abstract | Background: Transcranial direct current stimulation (tDCS) is a promising intervention for major depression. However, its clinical effects are heterogeneous. We investigated, in a subsample of the randomized, clinical trial Escitalopram versus Electrical Direct Current Therapy for Depression Study (ELECT-TDCS), whether the volumes of left and right prefrontal cortex (PFC) and anterior cingulate cortex (ACC) were associated with prefrontal tDCS response. Methods: Baseline structural T1 weighted MRI data were analyzed from 52 patients (15 males). Patients were randomized to the following conditions: escitalopram 20 mg/day, bifrontal tDCS (2 mA, 30min, 22 sessions), or placebo. Antidepressant outcomes were assessed over a treatment period of 10 weeks. Voxel-based gray matter volumes of PFC and ACC were determined using state-of-the-art parcellation approaches. Results: According to our a priori hypothesis, in the left dorsal PFC, larger gray matter volumes were associated with depression improvement in the tDCS group (n = 15) compared to sham (n = 21) (Cohen's d = 0.3, 95% confidence interval [0.01; 0.6], p = 0.04). Neither right PFC nor ACC volumes were associated with depression improvement. Exploratory analyses of distinct PFC subregions were performed, but no area was associated with tDCS response after correction for multiple comparisons. Conclusion: Left PFC baseline gray matter volume was associated with tDCS antidepressant effects. This brain region and its subdivisions should be investigated further as a potential neurobiological predictor for prefrontal tDCS treatment in depression and might be correlated with tDCS antidepressant mechanisms of action. | eng |
dc.description.sponsorship | Sao Paulo Research State Foundation (FAPESP) | - |
dc.language.iso | eng | - |
dc.publisher | ELSEVIER SCIENCE INC | eng |
dc.relation.ispartof | Brain Stimulation | - |
dc.rights | restrictedAccess | eng |
dc.subject | Antidepressant response | eng |
dc.subject | Magnetic resonance imaging | eng |
dc.subject | Major depressive disorder | eng |
dc.subject | Noninvasive brain stimulation | eng |
dc.subject | Structural neuroanatomy | eng |
dc.subject | Transcranial direct current stimulation | eng |
dc.subject.other | direct-current stimulation | eng |
dc.subject.other | transcranial magnetic stimulation | eng |
dc.subject.other | major depressive disorder | eng |
dc.subject.other | treatment-resistant depression | eng |
dc.subject.other | anterior cingulate cortex | eng |
dc.subject.other | accelerated hf-rtms | eng |
dc.subject.other | treating depression | eng |
dc.subject.other | current therapy | eng |
dc.subject.other | functional mri | eng |
dc.subject.other | brain | eng |
dc.title | Antidepressant effects of tDCS are associated with prefrontal gray matter volumes at baseline: Evidence from the ELECT-TDCS trial | eng |
dc.type | article | eng |
dc.rights.holder | Copyright ELSEVIER SCIENCE INC | eng |
dc.identifier.doi | 10.1016/j.brs.2019.05.006 | - |
dc.identifier.pmid | 31105027 | - |
dc.subject.wos | Clinical Neurology | eng |
dc.subject.wos | Neurosciences | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | BULUBAS, Lucia:Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Munich, Germany; IMPRS TP, Munich, Germany | - |
hcfmusp.author.external | PADBERG, Frank:Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Munich, Germany | - |
hcfmusp.author.external | GOERIGK, Stephan:Ludwig Maximilians Univ Munchen, Dept Psychol Methodol & Assessment, Munich, Germany; Univ Appl Sci, Hsch Fresenius, Munich, Germany | - |
hcfmusp.author.external | KEESER, Daniel:Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Munich, Germany; Ludwig Maximilians Univ Munchen, Dept Clin Radiol, Univ Hosp, Munich, Germany | - |
hcfmusp.description.beginpage | 1197 | - |
hcfmusp.description.endpage | 1204 | - |
hcfmusp.description.issue | 5 | - |
hcfmusp.description.volume | 12 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000481415500016 | - |
hcfmusp.origem.id | 2-s2.0-85065601641 | - |
hcfmusp.publisher.city | NEW YORK | eng |
hcfmusp.publisher.country | USA | eng |
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dc.description.index | MEDLINE | eng |
dc.identifier.eissn | 1876-4754 | - |
hcfmusp.citation.scopus | 31 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
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