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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorBULUBAS, Lucia-
dc.contributor.authorPADBERG, Frank-
dc.contributor.authorBueno, Priscila V.-
dc.contributor.authorDURAN, Fabio-
dc.contributor.authorBUSATTO, Geraldo-
dc.contributor.authorAMARO JR., Edson-
dc.contributor.authorBENSENOR, Isabela M.-
dc.contributor.authorLOTUFO, Paulo A.-
dc.contributor.authorGOERIGK, Stephan-
dc.contributor.authorGATTAZ, Wagner-
dc.contributor.authorKEESER, Daniel-
dc.contributor.authorBRUNONI, Andre R.-
dc.date.accessioned2019-09-23T14:20:13Z-
dc.date.available2019-09-23T14:20:13Z-
dc.date.issued2019-
dc.identifier.citationBRAIN STIMULATION, v.12, n.5, p.1197-1204, 2019-
dc.identifier.issn1935-861X-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/33551-
dc.description.abstractBackground: Transcranial direct current stimulation (tDCS) is a promising intervention for major depression. However, its clinical effects are heterogeneous. We investigated, in a subsample of the randomized, clinical trial Escitalopram versus Electrical Direct Current Therapy for Depression Study (ELECT-TDCS), whether the volumes of left and right prefrontal cortex (PFC) and anterior cingulate cortex (ACC) were associated with prefrontal tDCS response. Methods: Baseline structural T1 weighted MRI data were analyzed from 52 patients (15 males). Patients were randomized to the following conditions: escitalopram 20 mg/day, bifrontal tDCS (2 mA, 30min, 22 sessions), or placebo. Antidepressant outcomes were assessed over a treatment period of 10 weeks. Voxel-based gray matter volumes of PFC and ACC were determined using state-of-the-art parcellation approaches. Results: According to our a priori hypothesis, in the left dorsal PFC, larger gray matter volumes were associated with depression improvement in the tDCS group (n = 15) compared to sham (n = 21) (Cohen's d = 0.3, 95% confidence interval [0.01; 0.6], p = 0.04). Neither right PFC nor ACC volumes were associated with depression improvement. Exploratory analyses of distinct PFC subregions were performed, but no area was associated with tDCS response after correction for multiple comparisons. Conclusion: Left PFC baseline gray matter volume was associated with tDCS antidepressant effects. This brain region and its subdivisions should be investigated further as a potential neurobiological predictor for prefrontal tDCS treatment in depression and might be correlated with tDCS antidepressant mechanisms of action.eng
dc.description.sponsorshipSao Paulo Research State Foundation (FAPESP)-
dc.language.isoeng-
dc.publisherELSEVIER SCIENCE INCeng
dc.relation.ispartofBrain Stimulation-
dc.rightsrestrictedAccesseng
dc.subjectAntidepressant responseeng
dc.subjectMagnetic resonance imagingeng
dc.subjectMajor depressive disordereng
dc.subjectNoninvasive brain stimulationeng
dc.subjectStructural neuroanatomyeng
dc.subjectTranscranial direct current stimulationeng
dc.subject.otherdirect-current stimulationeng
dc.subject.othertranscranial magnetic stimulationeng
dc.subject.othermajor depressive disordereng
dc.subject.othertreatment-resistant depressioneng
dc.subject.otheranterior cingulate cortexeng
dc.subject.otheraccelerated hf-rtmseng
dc.subject.othertreating depressioneng
dc.subject.othercurrent therapyeng
dc.subject.otherfunctional mrieng
dc.subject.otherbraineng
dc.titleAntidepressant effects of tDCS are associated with prefrontal gray matter volumes at baseline: Evidence from the ELECT-TDCS trialeng
dc.typearticleeng
dc.rights.holderCopyright ELSEVIER SCIENCE INCeng
dc.identifier.doi10.1016/j.brs.2019.05.006-
dc.identifier.pmid31105027-
dc.subject.wosClinical Neurologyeng
dc.subject.wosNeuroscienceseng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
hcfmusp.author.externalBULUBAS, Lucia:Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Munich, Germany; IMPRS TP, Munich, Germany-
hcfmusp.author.externalPADBERG, Frank:Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Munich, Germany-
hcfmusp.author.externalGOERIGK, Stephan:Ludwig Maximilians Univ Munchen, Dept Psychol Methodol & Assessment, Munich, Germany; Univ Appl Sci, Hsch Fresenius, Munich, Germany-
hcfmusp.author.externalKEESER, Daniel:Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Munich, Germany; Ludwig Maximilians Univ Munchen, Dept Clin Radiol, Univ Hosp, Munich, Germany-
hcfmusp.description.beginpage1197-
hcfmusp.description.endpage1204-
hcfmusp.description.issue5-
hcfmusp.description.volume12-
hcfmusp.origemWOS-
hcfmusp.origem.idWOS:000481415500016-
hcfmusp.origem.id2-s2.0-85065601641-
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUSAeng
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dc.identifier.eissn1876-4754-
hcfmusp.citation.scopus31-
hcfmusp.scopus.lastupdate2024-03-29-
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