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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSTEIN, Dan J.
dc.contributor.authorCOSTA, Daniel L. C.
dc.contributor.authorLOCHNER, Christine
dc.contributor.authorMIGUEL, Euripedes C.
dc.contributor.authorREDDY, Y. C. Janardhan
dc.contributor.authorSHAVITT, Roseli C.
dc.contributor.authorHEUVEL, Odile A. van den
dc.contributor.authorSIMPSON, H. Blair
dc.identifier.citationNATURE REVIEWS DISEASE PRIMERS, v.5, article ID 52, 21p, 2019
dc.description.abstractObsessive-compulsive disorder (OCD) is a highly prevalent and chronic condition that is associated with substantial global disability. OCD is the key example of the 'obsessive-compulsive and related disorders', a group of conditions which are now classified together in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, and the International Classification of Diseases, 11th Revision, and which are often underdiagnosed and undertreated. In addition, OCD is an important example of a neuropsychiatric disorder in which rigorous research on phenomenology, psychobiology, pharmacotherapy and psychotherapy has contributed to better recognition, assessment and outcomes. Although OCD is a relatively homogenous disorder with similar symptom dimensions globally, individualized assessment of symptoms, the degree of insight, and the extent of comorbidity is needed. Several neurobiological mechanisms underlying OCD have been identified, including specific brain circuits that underpin OCD. In addition, laboratory models have demonstrated how cellular and molecular dysfunction underpins repetitive stereotyped behaviours, and the genetic architecture of OCD is increasingly understood. Effective treatments for OCD include serotonin reuptake inhibitors and cognitive-behavioural therapy, and neurosurgery for those with intractable symptoms. Integration of global mental health and translational neuroscience approaches could further advance knowledge on OCD and improve clinical outcomes.eng
dc.relation.ispartofNature Reviews Disease Primers
dc.subject.otherserotonin reuptake inhibitorseng
dc.subject.othertranscranial magnetic stimulationeng
dc.subject.othercognitive-behavior therapyeng
dc.subject.othervoxel-based metaanalysiseng
dc.subject.otherdeep brain-stimulationeng
dc.subject.otherattention-deficit/hyperactivity disordereng
dc.subject.othern-acetylcysteine augmentationeng
dc.subject.otherenvironmental risk-factorseng
dc.titleObsessive-compulsive disordereng
dc.rights.holderCopyright NATURE PUBLISHING GROUPeng
dc.subject.wosMedicine, General & Internaleng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Dan J.:Univ Cape Town, Dept Psychiat, Cape Town, South Africa; SA MRC Unit Risk & Resilience Mental Disorders, Cape Town, South Africa, Christine:Stellenbosch Univ, Dept Psychiat, Stellenbosch, South Africa; SA MRC Unit Risk & Resilience Mental Disorders, Stellenbosch, South Africa, Y. C. Janardhan:Natl Inst Mental Hlth & Neurosci, Dept Psychiat, Bangalore, Karnataka, India, Odile A. van den:Vrije Univ Amsterdam, Dept Psychiat, Amsterdam Neurosci, Amsterdam UMC, Amsterdam, Netherlands; Vrije Univ Amsterdam, Dept Anat & Neurosci, Amsterdam Neurosci, Amsterdam UMC, Amsterdam, Netherlands, H. Blair:Columbia Univ, Dept Psychiat, New York, NY USA; New York State Psychiat Inst & Hosp, New York, NY 10032 USA
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