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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCINEGAGLIA, Naiara
dc.contributor.authorANTONIAZZI, Luiza
dc.contributor.authorROSA, Daniela
dc.contributor.authorMIRANDA, Debora
dc.contributor.authorACOSTA-NAVARRO, Julio
dc.contributor.authorBORTOLOTTO, Luiz
dc.contributor.authorHONG, Valeria
dc.contributor.authorSANDRIM, Valeria
dc.identifier.citationAGING-US, v.11, n.14, p.5070-5080, 2019
dc.description.abstractTelomere length is considered to be a biomarker of biological aging and age-related disease. There are few studies that have evaluated the association between telomere length and diet, and none of them have evaluated the impact of a vegetarian diet on telomere length and its correlation with cardiovascular biomarkers in apparently healthy subjects. Therefore, our objectives were to evaluate leukocyte telomere length (LTL) in vegetarians and omnivorous subjects and its association with classical cardiovascular risk biomarkers. From the total of 745 participants initially recruited, 44 omnivorous and 44 vegetarian men apparently healthy were selected for this study and LTL was measured in 39 omnivorous and 41 vegetarians by Real-Time Quantitative PCR reaction. Although telomere length was not different between omnivorous and vegetarians, we found a strong negative correlation between LTL and IMT (intima-media thickness) in omnivorous, but not in vegetarian group. In addition, omnivorous who were classified with short telomere length had higher carotid IMT compared to vegetarians. Our data suggest that telomere length can be a marker of subclinical atherosclerosis in the omnivorous group.eng
dc.description.sponsorshipNational Council for Scientific and Technological Development (CNPq) [2014-5/305587]
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP-Brazil) [2015/20669-8]
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipFoundation for Research of the State of Minas Gerais (FAPEMIG)
dc.publisherIMPACT JOURNALS LLCeng
dc.subjecttelomere lengtheng
dc.subjectcarotid intima-media thicknesseng
dc.subject.otherintimal-medial thicknesseng
dc.subject.otherdietary patternseng
dc.titleShortening telomere is associated with subclinical atherosclerosis biomarker in omnivorous but not in vegetarian healthy meneng
dc.rights.holderCopyright IMPACT JOURNALS LLCeng
dc.subject.wosCell Biologyeng
dc.subject.wosGeriatrics & Gerontologyeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Naiara:Sao Paulo State Univ IBB UNESP, Inst Biosci, Botucatu, SP, Brazil, Daniela:Univ Fed Minas Gerais, Med Sch, Lab Mol Med, UFMG, Belo Horizonte, MG, Brazil, Debora:Univ Fed Minas Gerais, Med Sch, Lab Mol Med, UFMG, Belo Horizonte, MG, Brazil, Valeria:Sao Paulo State Univ IBB UNESP, Inst Biosci, Botucatu, SP, Brazil
hcfmusp.publisher.cityORCHARD PARKeng
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